Date published: 2026-11-7

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gp91phox/CYBB/NOX2 Antibody (G-1) - Western Blotting - Image 17381
gp91-phox 抗体 (G-1): sc-74514. COLO 320DM (A), Hep G2 (B), OV-90 (C) 和 A-10 (D) 全细胞裂解液中 gp91-phox 表达的 Western 印迹分析.
gp91phox/CYBB/NOX2 Antibody (G-1) - Western Blotting - Image 17381
gp91-phox 抗体 (G-1): sc-74514. COLO 320DM (A), Hep G2 (B), OV-90 (C) 和 A-10 (D) 全细胞裂解液中 gp91-phox 表达的 Western 印迹分析.
gp91phox/CYBB/NOX2 Antibody (G-1) - Western Blotting - Image 352065
gp91-phox 抗体 (G-1): sc-74514. U-937 (A), HT-29 (B) 和 COLO 205 (C) 全细胞裂解液中 gp91-phox 表达的 Western 印迹分析.
gp91-phox 抗体 (G-1): sc-74514. COLO 320DM (A), Hep G2 (B), OV-90 (C) 和 A-10 (D) 全细胞裂解液中 gp91-phox 表达的 Western 印迹分析.

gp91phox/CYBB/NOX2 抗体 (G-1): sc-74514

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说明书
  • gp91phox/CYBB/NOX2抗体(G-1)是小鼠单克隆IgG1 κ, 在41篇文献中引用，规格为200 µg/ml
  • 免疫human物种的gp91-phox的氨基酸231-290
  • 推荐用于 mouse, rat 和 human 来源的gp91-phox WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是gp91phox/CYBB/NOX2 Antibody (G-1) for WB applications. 的首选辅助检测试剂，这些试剂现与gp91phox/CYBB/NOX2 Antibody (G-1) 打包提供（请参阅下面的订购信息）。
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gp91-phox抗体（G-1）是一种IgG1 κ小鼠单克隆gp91-phox抗体（也称为gp91-phox抗体或CYBB抗体），可通过WB、IP、IF和ELISA检测小鼠、大鼠和人源的gp91-phox。gp91-phox抗体（G-1）为非偶联的抗gp91-phox抗体形式。Mox1和糖蛋白gp91-phox是密切相关的蛋白质，它们是NADPH氧化酶的重要组成部分。产生超氧化物的NADPH氧化酶存在于吞噬细胞、神经上皮体、血管平滑肌细胞和内皮细胞中。它包括一个膜结合的黄素细胞色素，该细胞色素含有两个亚基gp91-phox和p22-phox，以及胞质蛋白p47-phox和p67-phox。在NADPH氧化酶激活过程中，p47-phox和p67-phox迁移到质膜，在那里它们与黄素细胞色素b558结合，形成有活性的酶复合物。p22-和gp91-phox亚基还作为表面O2传感器，在缺氧条件下启动细胞信号传导。Mox1和gp91具有相同的C末端序列，但它们的表达模式不同。gp91-phox在嗜酸性粒细胞、中性粒细胞、单核细胞和B淋巴细胞中表达，而Mox1主要在结肠中检测到，在子宫和前列腺中也有低表达。Mox1在血管平滑肌细胞中对PDGF刺激也有上调反应，这共同表明Mox1可能与gp91-phox有类似的功能，但在非吞噬细胞中调节NADPH超氧化物的产生。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

含汞：所有HRP偶联物（包括组合装）均含有硫柳汞，这是一种汞化合物。请勿丢弃在垃圾中。应按照当地、州和联邦法规，将其作为危险化学品废弃物进行处置。

下载硫柳汞安全数据表（SDS）

gp91phox/CYBB/NOX2 抗体 (G-1) 参考文献:

  1. Gp91（phox）有助于实验性炎症性肠病的发生。  |  Bao, S., et al. 2011. Immunol Cell Biol. 89: 853-60. PMID: 21321580
  2. NADPH氧化酶gp91phox通过上调NFATc1促进RANKL诱导的破骨细胞分化。  |  Kang, IS. and Kim, C. 2016. Sci Rep. 6: 38014. PMID: 27897222
  3. gp91phox在肝巨噬细胞编程和酒精性肝病中的作用。  |  Wang, M., et al. 2017. Hepatol Commun. 1: 765-779. PMID: 29404493
  4. 人中性粒细胞中 gp91phox/NOX2 的磷酸化。  |  Raad, H., et al. 2019. Methods Mol Biol. 1982: 341-352. PMID: 31172483
  5. 查尔酮骨架促进gp91-phox基因的转录，但抑制gp91-phox蛋白的表达，羟基查尔酮中的羟基参与gp91-phox蛋白的稳定表达。  |  Kikuchi, H., et al. 2019. Microbiol Immunol. 63: 438-443. PMID: 31329291
  6. 评估氧化应激的新型生物标记物gp91phox在亚临床甲状腺功能减退症中升高  |  Ma, X., et al. 2020. Int J Endocrinol. 2020: 3161730. PMID: 32454820
  7. 鞣花酸及其发酵衍生物尿囊素A对gp91-phox基因表达具有相反的作用，导致全反式维甲酸诱导的U937细胞超氧化物生成活性发生相反的改变。  |  Kikuchi, H., et al. 2021. Biochem Biophys Rep. 25: 100891. PMID: 33490645

订购信息

产品名称产品编号规格价格数量收藏夹

gp91phox/CYBB/NOX2 抗体 (G-1)

sc-74514
200 µg/ml
CNY2422.00

gp91phox/CYBB/NOX2 (G-1): m-IgG Fc BP-HRP 套装

sc-527034
200 µg Ab; 10 µg BP
CNY2715.00

gp91phox/CYBB/NOX2 (G-1): m-IgG1 BP-HRP 套装

sc-532407
200 µg Ab; 20 µg BP
CNY2715.00

Is this antibody available conjugated to HRP or Alkaline Phosphatase?

Asked by: Eric
Thank you for your question. At this time, we only have the unconjugated form.
Answered by: BlakeJ
Date published: 2026-04-14

Can I request a small amount for testing the AB? Is this feasible? Kind regards,Roberto.

Asked by: Roberto
Thank you for your question. Please contact our technical service team directly to make arrangements for a sample of this antibody.
Answered by: Tech Support Europe
Date published: 2024-03-28

gp91phox/CYBB/NOX2 Antibody (G-1): sc-74514. It says the 200ug/mL is $304 but what is the total volume we get?

Asked by: Janith
Thank you for your question. You will receive 1ml.
Answered by: BlakeJ
Date published: 2023-12-29

What is the total volume provided of gp91-phox (G-1): sc-74514 monoclonal antibody?

Asked by: jenni
Each vial contains 200 µg IgG1 kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
Answered by: Technical Support 15
Date published: 2017-02-05
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Rated 5 out of 5 by CAT HUI from REAL GREATI bought this antibody 1 month ago and have used it for WB in H9C2 cell.The figures are real clear and obvious.
Date published: 2017-05-31
Rated 5 out of 5 by cjMara from Great for WB!Although there are several gp91-phox clones available to choose from, the (G-1) clone is an excellent choice for WB while the other options are preferred for IHC(P).
Date published: 2017-01-12
Rated 5 out of 5 by MS from Used for western blotting with murine prostateUsed for western blotting with murine prostate extracts. -SCBT Publication Review
Date published: 2015-05-05
Rated 5 out of 5 by MC from Successfully used to pull down gp91Successfully used to pull down gp91-phox protein. -SCBT Publication Review
Date published: 2015-05-02
Rated 5 out of 5 by FL from Published data for WB with human Renal MesangialPublished data for WB with human Renal Mesangial Cells. -SCBT Publication Review
Date published: 2015-01-28
Rated 5 out of 5 by MS from ELISA/WB using A549 epithelial cell lysatesELISA/WB using A549 epithelial cell lysates. -SCBT Publication Review
Date published: 2015-01-20
Rated 4 out of 5 by LF from Positive results in western blot analysis of gp91Positive results in western blot analysis of gp91-phox expression in COLO 320DM, Hep G2, OV-90 and A-10 whole cell lysates. -SCBT QC
Date published: 2014-03-29
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gp91phox/CYBB/NOX2抗体 (G-1) is rated 4.9 out of 5 by 7.
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