Date published: 2025-9-7

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GHR 抗体 (MAB 263): sc-57161

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说明书
  • GHR抗体(MAB 263)是小鼠单克隆IgG1 κ, 在7篇文献中引用,规格为200 µg/ml
  • 针对纯化的GHR rat and rabbit 起源
  • 推荐用于 mouse, rat, human 和 rabbit 来源的GHR WB, IP, IF, IHC(P) 和 FCM检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 还提供无叠氮化物,部分阻断GH在兔和大鼠体内的结合,并用作生长激素激动剂,sc-57161 L,200 µg/0.1 ml
  • 看 GHR (B-10): sc-137185,可查看有标记的 GHR 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 GHR 抗体 (MAB 263) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与GHR 抗体 (MAB 263) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

生长激素受体(GHR)结合生长激素(GH),生长激素由垂体前叶产生,调节身体生长和其他代谢过程。 GHR是一种完整的膜蛋白,是细胞因子受体家族的成员。细胞因子受体家族的一个共同特征是具有可溶形式的蛋白质。 GHR的可溶形式是GH结合蛋白(GHBP),其由GHR的细胞外结构域的蛋白水解切割产生。 GHBP水平降低与GH不敏感综合征(GHIS)有关。 GHR已被证明是通过至少两个不同的启动子转录的,产生GHR 1A和GHR 1B。 GHR 1A和1B都在肝脏中表达,而GHR 1B也在肌肉、子宫和卵巢组织中表达。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

GHR 抗体 (MAB 263) 参考文献:

  1. 生长激素受体(GHR)的解构:组织特异性GHR基因缺失小鼠的物理和代谢表型。  |  Young, JA., et al. 2016. Prog Mol Biol Transl Sci. 138: 27-39. PMID: 26940385
  2. GH和GHR在人类疾病中的信号传导。  |  Guevara-Aguirre, J., et al. 2018. Growth Horm IGF Res. 38: 34-38. PMID: 29395968
  3. 生长激素信号转导中GHR-JAK2-STAT通路的受体后抑制剂。  |  Wójcik, M., et al. 2018. Int J Mol Sci. 19: PMID: 29932147
  4. 生长激素不敏感的遗传原因超出了GHR。  |  Hwa, V., et al. 2021. Rev Endocr Metab Disord. 22: 43-58. PMID: 33029712
  5. 禁食时下丘脑GHR-SIRT1轴。  |  de Lima, JBM., et al. 2021. Cells. 10: PMID: 33919674
  6. ARCGHR神经元调节肌肉葡萄糖摄取。  |  de Lima, JBM., et al. 2021. Cells. 10: PMID: 34063647
  7. GHR和IGF1R基因突变可能是SGA儿童缺乏追赶性生长的潜在原因。  |  Stróżewska, W., et al. 2022. Genes (Basel). 13: PMID: 35627241
  8. GHR表达与前列腺癌增殖。  |  Thomas, T. 2023. Nat Rev Urol. 20: 131. PMID: 36781984
  9. 生长激素受体(GHR)信号对肝糖酵解、从头脂质生成和胰岛素敏感性的直接和系统性作用与脂肪变性有关。  |  Vázquez-Borrego, MC., et al. 2023. Metabolism. 144: 155589. PMID: 37182789
  10. 在肌细胞分化过程中,局部GHR通过线粒体生物发生调节线粒体功能。  |  Hu, B., et al. 2023. Cell Commun Signal. 21: 148. PMID: 37337300

订购信息

产品名称产品编号规格价格数量收藏夹

GHR 抗体 (MAB 263)

sc-57161
200 µg/ml
RMB2377.00

GHR (MAB 263): m-IgG Fc BP-HRP 套装

sc-539049
200 µg Ab; 10 µg BP
RMB2662.00

GHR (MAB 263): m-IgG1 BP-HRP 套装

sc-541228
200 µg Ab; 20 µg BP
RMB2662.00

GHR 抗体 (MAB 263) FITC

sc-57161 FITC
200 µg/ml
RMB2482.00

GHR 抗体 (MAB 263) L

sc-57161 L
200 µg/0.1 ml
RMB2377.00

GHR 抗体 (MAB 263) PE

sc-57161 PE
200 µg/ml
RMB2580.00

大正製薬株式会社の落合です。こちらの製品の購入を希望していますが、社内手続き上SDSデータシートが必要です。SDSデータシートをご教示頂けましたら幸いです。

Asked by: Nagahiro
Thank you very much for your question. Sorry, we do not provide SDS for antibodies. 質問頂き、誠にありがとうございます。申し訳ございませんが、抗体のSDSは提供しておりません。
Answered by: Jiajun Z
Date published: 2025-08-07

Is it possible to obtain the sequence of the GHR Antibody (MAB 263): sc-57161?

Asked by: Omar
Thank you for your question. The sequence is proprietary but here is more information on the protein : https://www.uniprot.org/uniprotkb/P10912/entry
Answered by: BlakeJ
Date published: 2024-08-06

Does Mab263 have ADCC (Antibody-Dependent Cellular Cytotoxicity) or CDC (Complement-Dependent Cytotoxicity) effects?

Asked by: ling0423
Thank you for your question. Growth Hormone Receptor (GHR) is not known to exhibit Antibody-Dependent Cellular Cytotoxicity (ADCC) or Complement-Dependent Cytotoxicity (CDC) effects.
Answered by: Ling Chen
Date published: 2024-07-31

Has this monoclonal ever been tested for cross reactivity to p GHR? If not, could I receive a sample to try in pig?

Asked by: AmyD
For sample information please contact Technical Service.
Answered by: Tech Sales
Date published: 2022-08-17

Can GHR (MAB 263): sc-57161 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: TinTin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, GHR (MAB 263): sc-57161 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-03-03
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Rated 5 out of 5 by from IP and WB publishable data with human liverIP and WB publishable data with human liver - SCBT Publication Review
Date published: 2013-01-10
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GHR 抗体 (MAB 263) is rated 5.0 out of 5 by 1.
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