Gentamicin sulfate CAS: 1405-41-0
MF: C21H43N5O7•H2SO4
MW: 575.67

Gentamicin sulfate (CAS 1405-41-0)

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Alternate Names: Gentamicin sulfate also known as Alcomicin; Bristagen; Cidomycin; Duragentam; Garamycin; Garasol; Genoptic; Gentacidin; Gentacin; Gentaglyde; Gentalyn; Gentamicin C Complex Citrate; Gentibioptal; Genticin; Gentocin; Gentogram; Gent-Ophtal; Getalline; GM Sulfate
Application: Gentamicin sulfate is a useful broad-spectrum cell culture antibiotic which inhibits protein synthesis
CAS Number: 1405-41-0
Molecular Weight: 575.67
Molecular Formula: C21H43N5O7•H2SO4
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Gentamycin Sulfate is a broad-spectrum, aminoglycoside antibiotic used for cell culture which inhibits protein synthesis in sensitive organisms. Gentamicin sulfate inhibits protein synthesis by binding to L6 protein and 50S ribosomal subunit. Gentamicin sulfate is reported to have activity against gram-negative bacteria, Pseudomonas aeruginosa, gram-positive Staphylococcus aureus and some mycoplasmas. Gentamicin sulfate is reported to have low toxicity to mammalian cells and viruses at certain concentrations, and Gentamicin sulfate is useful for long-term tissue culture studies with viruses. This compound is a mixture of Gentamycin c1, c1a and c2.


参考文献

1. Martin, N.L., et al 1986. Antimicrob. Agents Chemother. 29: 1079-1087. PMID: 2425732

2. Kadurugamuwa, J.L., et al. 1993. J. Bacteriol. 175(: 5798-5805. PMID: 8376327

3. Montenez, J.P., et al. 1994. Toxicol. Lett. 73: 201-208. PMID: 8091428

Formulation :
a mixture of 3 major components, Gentamicin C1, C1a and C2
Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (115 mg/ml at 25° C), DMSO (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Store at 4° C
Refractive Index :
n20D 1.58 (Predicted)
Optical Activity :
α20D 102
仅供科研使用。不可用于诊断或治疗。
MDL Number :
MFCD00270181
EC Number :
215-778-9
SMILES :
CC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)NC.OS(=O)(=O)O

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Citations 1 to 1 of 1 total

PMID: # 30156610  Coutinho, AGG.|Biscaia, SMP.|Fernandez, R.|Tararthuch, AL.| et al. 2018. Braz. J. Med. Biol. Res. 51: e7417.

Citations 1 to 1 of 1 total
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