Date published: 2025-9-7
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GDF-11 Antibody (X-19) - Western Blotting - Image 33602
GDF-11 抗体 (X-19): sc-81952. K-562 全细胞裂解液中 GDF-11 表达的 Western 印迹分析.
GDF-11 Antibody (X-19) - Western Blotting - Image 33602
GDF-11 抗体 (X-19): sc-81952. K-562 全细胞裂解液中 GDF-11 表达的 Western 印迹分析.
GDF-11 Antibody (X-19) - Western Blotting - Image 126047
GDF-11 抗体 (X-19): sc-81952. 未转染 293: sc-110760 (A), 转染小鼠 GDF-11 的 293: sc-178664 (B) 和 SW480 (C) 全细胞裂解液中 GDF-11 表达的 Western 印迹分析.
GDF-11 抗体 (X-19): sc-81952. K-562 全细胞裂解液中 GDF-11 表达的 Western 印迹分析.

GDF-11 抗体 (X-19): sc-81952

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寫評論提問

说明书
  • GDF-11抗体(X-19)是小鼠单克隆IgG2a κ, 在8篇文献中引用，规格为100 µg/ml
  • 免疫human物种的重组GDF-11
  • 推荐用于 mouse, rat 和 human 来源的GDF-11 WB, IP 和 ELISA检测
  • 看 GDF-8/11 (H-9): sc-393335，可查看有标记的 GDF-11 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 关于如何获取GDF-11 (X-19): sc-81952的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成GDF-11 抗体 (X-19)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 GDF 抗体 包括 GDF-11, GDF-15, GDF-16, GDF-5, GDF-6, GDF-7, GDF-8, GDF-9和GDF-9B

GDF-11抗体（X-19）是一种小鼠单克隆IgG2a kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）和酶联免疫吸附测定（ELISA）等方法检测小鼠、大鼠和人类样本中的GDF-11。抗GDF-11抗体（X-19）以非结合形式提供，可在各种实验设置中灵活使用。GDF-11是转化生长因子β（TGF-β）超家族的重要成员，通过调节Gdnf等基因的表达，在调节轴向骨骼和器官发生的前/后模式方面发挥着重要作用。值得注意的是，GDF-11参与Smad2的磷酸化，这是TGF-β信号传导通路的关键步骤，对于正常的细胞通讯和发育过程至关重要。此外，GDF-11在左右对称模式中介导Nodal信号，对于头部结构的发展至关重要。GDF-11对嗅觉上皮祖细胞产生新神经元的抑制作用凸显了其在神经发生和维持神经干细胞群中的重要性。GDF-11能够影响如此多样的生物过程，这凸显了其在发育生物学中的重要性以及在再生医学中的潜在意义。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

GDF-11 抗体 (X-19) 参考文献:

  1. 生长/分化因子 11 对轴向骨骼前/后模式化的调控。  |  McPherron, AC., et al. 1999. Nat Genet. 22: 260-4. PMID: 10391213
  2. 轴发育：老鼠变成了腊肠犬。  |  Gad, JM. and Tam, PP. 1999. Curr Biol. 9: R783-6. PMID: 10531023
  3. Gdf11 是雏鸡肢体发育过程中软骨形成和肌肉生成的负调控因子。  |  Gamer, LW., et al. 2001. Dev Biol. 229: 407-20. PMID: 11203700
  4. 指定脊髓运动神经元的位置特征：FGF, Gdf11和视黄醇对Hox-c表达的喙尾模式化。  |  Liu, JP., et al. 2001. Neuron. 32: 997-1012. PMID: 11754833
  5. 激活素 IIA 型和 IIB 型受体介导 Gdf11 信号在脊椎轴向模式化中的作用  |  Oh, SP., et al. 2002. Genes Dev. 16: 2749-54. PMID: 12414726
  6. GDF11 对神经发生的自动调节。  |  Wu, HH., et al. 2003. Neuron. 37: 197-207. PMID: 12546816
  7. 生长/分化因子 11 对肾小球肾脏发育的调控  |  Esquela, AF. and Lee, SJ. 2003. Dev Biol. 257: 356-70. PMID: 12729564
  8. 恢复全身 GDF11 水平可逆转小鼠骨骼肌与年龄相关的功能障碍。  |  Sinha, M., et al. 2014. Science. 344: 649-52. PMID: 24797481
  9. 系统性 GDF11 通过刺激神经元自噬减轻老年小鼠的抑郁样表型  |  Moigneu, C., et al. 2023. Nat Aging. 3: 213-228. PMID: 37118117
  10. GDF-11 作为一种潜在的心脏促血管生成因子  |  Kato, T. and Lee, RT. 2023. JACC Basic Transl Sci. 8: 636-637. PMID: 37426538
  11. 循环中的 GDF11 会加剧小鼠的心肌损伤，并与人类心肌梗死面积的增加有关。  |  Kraler, S., et al. 2023. Cardiovasc Res. 119: 2729-2742. PMID: 37742057
  12. GDF11 通过抑制 p21 来减缓兴奋性神经元衰老和大脑老化。  |  Wang, DX., et al. 2023. Nat Commun. 14: 7476. PMID: 37978295

订购信息

产品名称产品编号规格价格数量收藏夹

GDF-11 抗体 (X-19)

sc-81952
100 µg/ml
$333.00

Which are the union sites of GDF-11 (X-19) antibody recognition sites on the protein?

Asked by: Anonymous
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-23

This antibody is predicted to cross react with GDF8 ?.

Asked by: Paolo61
Thank you for your question. GDF-11 Antibody (X-19): sc-81952 has been raised against recombinant GDF-11 of human origin. We have no data indicating whether or not GDF-11 Antibody (X-19): sc-81952 reacts with GDF8 as well. As both proteins share little homology, it is unlikely that the antibody would recognize GDF8. Please contact our technical service for more information or to arrange for a free sample of this antibody to test it in your application.
Answered by: SCBT Heidelberg Support
Date published: 2019-01-06

Is the GDF-11 (X-19): sc-81952 monoclonal antibody available conjugated to FITC?

Asked by: cjMara
Please contact one of our Special Orders Coordinators to inquire about the availability of custom conjugates for GDF-11 (X-19): sc-81952 monoclonal antibody. Email [email protected]. Or call our Technical Service Department at (800) 457-3801 option 2. Alternatively, we offer a different antibody, GDF-8/11 (H-9): sc-393335, available with a variety of conjugations including FITC.
Answered by: Technical Support 5
Date published: 2017-01-20
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Rated 5 out of 5 by from Fast acting with great resultsDoing research trials to confirm results and mine match the lab results cant wait for human trials to confirm results.
Date published: 2017-10-10
Rated 5 out of 5 by from Strong WBOutstanding antibody for western blot applications
Date published: 2017-02-05
Rated 5 out of 5 by from Great choice of antibody!Good choice for detection of GDF-11 by Western blot.
Date published: 2016-12-28
Rated 5 out of 5 by from Positive signal in WB in mouse GDFPositive signal in WB in mouse GDF-11 transfected 293 and SW480 whole cell lysates. -SCBT QC
Date published: 2015-04-20
Rated 5 out of 5 by from Strong band in WB in KStrong band in WB in K-562 whole cell lysates. -SCBT QC
Date published: 2013-10-23
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GDF-11 抗体 (X-19) is rated 5.0 out of 5 by 5.
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