Date published: 2025-9-7

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Gas6 抗体 (A-9): sc-376087

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说明书
  • Gas6 抗体 A-9 是小鼠单克隆 IgG2b κ,Gas6抗体, 在7篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列481-620位于human物种的Gas6的C-terminus附近
  • Gas6 抗体 (A-9) 推荐用于WB, IP, IF 和 ELISA,检测human 来源的 Gas6
  • 抗Gas6抗体(A-9)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Gas6 (A-9): sc-376087免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP2b BP-HRP">m-IgG2b BP-HRP是Gas6 Antibody (A-9) 适用于 WB 应用。 的首选辅助检测试剂,这些试剂现与Gas6 Antibody (A-9) 打包提供(请参阅下面的订购信息)。

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関連項目

Gas6抗体(A-9)是一种IgG2b κ小鼠单克隆Gas6抗体(也称为GAS6蛋白抗体、生长停滞特异性6抗体、AXL受体酪氨酸激酶配体抗体、生长停滞特异性蛋白6抗体、AXL刺激因子抗体、AXLLG抗体、AXSF抗体或GAS-6抗体),可通过WB、IP、IF和ELISA检测人源Gas6蛋白。Gas6抗体(A-9)既可以是非偶联形式的抗Gas6抗体,也可以是多种偶联形式的抗Gas6抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。生长停滞特异性蛋白,包括Gas 1和Gas 6,在静止细胞中被激活。Gas 1诱导的生长停滞由p53介导,Gas 1似乎能够抑制肿瘤细胞生长。Gas 6是酪氨酸激酶受体Axl的配体,最初被鉴定为维生素K依赖性蛋白家族的成员,并且与蛋白S(凝血途径中的负性共调节因子)具有高度相似的氨基酸序列同源性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Gas6 抗体 (A-9) 参考文献:

  1. Gas6/Axl 系统:血管细胞功能的新型调节器。  |  Melaragno, MG., et al. 1999. Trends Cardiovasc Med. 9: 250-3. PMID: 11094334
  2. 生长停滞特异基因 gas1 参与生长抑制。  |  Del Sal, G., et al. 1992. Cell. 70: 595-607. PMID: 1505026
  3. 维生素 K 依赖性生长因子 Gas6 在肾小球病理生理学中的作用。  |  Yanagita, M. 2004. Curr Opin Nephrol Hypertens. 13: 465-70. PMID: 15199298
  4. 皮质酮抑制 GAS6,从而控制毛囊干细胞的静止。  |  Choi, S., et al. 2021. Nature. 592: 428-432. PMID: 33790465
  5. 哺乳动物细胞生长停滞时特异表达的基因。  |  Schneider, C., et al. 1988. Cell. 54: 787-93. PMID: 3409319
  6. Gas6/Axl信号通路在癌症中的治疗靶向。  |  Tanaka, M. and Siemann, DW. 2021. Int J Mol Sci. 22: PMID: 34576116
  7. 嵌合Gas6融合蛋白对淀粉样蛋白-β的抗炎清除作用  |  Jung, H., et al. 2022. Nat Med. 28: 1802-1812. PMID: 35927581
  8. 下调的GAS6会损害滑膜巨噬细胞的排泄功能,并促进肥胖相关性骨关节炎的发生。  |  Yao, Z., et al. 2023. Elife. 12: PMID: 37144868
  9. 抗凝因子蛋白 S 及其近亲 Gas6 是受体酪氨酸激酶 Tyro 3/Axl 家族的配体。  |  Stitt, TN., et al. 1995. Cell. 80: 661-70. PMID: 7867073
  10. 抑制生长的鼠 gas1 基因人类同源物的结构, 功能和染色体图谱。  |  Del Sal, G., et al. 1994. Proc Natl Acad Sci U S A. 91: 1848-52. PMID: 8127893
  11. 生长停滞特异性基因(gas6)编码的蛋白是与蛋白 S 相关的维生素 K 依赖性蛋白中的一个新成员,蛋白 S 是血液凝固级联中的一个负核心调节因子。  |  Manfioletti, G., et al. 1993. Mol Cell Biol. 13: 4976-85. PMID: 8336730
  12. Gas1 诱导的生长抑制需要独立于 p53 功能的转录激活。  |  Del Sal, G., et al. 1995. Mol Cell Biol. 15: 7152-60. PMID: 8524283

订购信息

产品名称产品编号规格价格数量收藏夹

Gas6 抗体 (A-9)

sc-376087
200 µg/ml
$316.00

Gas6 (A-9): m-IgG Fc BP-HRP 套装

sc-525994
200 µg Ab; 10 µg BP
$354.00

Gas6 (A-9): m-IgG2b BP-HRP 套装

sc-549658
200 µg Ab; 10 µg BP
$354.00

Gas6 抗体 (A-9) AC

sc-376087 AC
500 µg/ml, 25% agarose
$416.00

Gas6 抗体 (A-9) HRP

sc-376087 HRP
200 µg/ml
$316.00

Gas6 抗体 (A-9) FITC

sc-376087 FITC
200 µg/ml
$330.00

Gas6 抗体 (A-9) PE

sc-376087 PE
200 µg/ml
$343.00

Gas6 抗体 (A-9) Alexa Fluor® 488

sc-376087 AF488
200 µg/ml
$357.00

Gas6 抗体 (A-9) Alexa Fluor® 546

sc-376087 AF546
200 µg/ml
$357.00

Gas6 抗体 (A-9) Alexa Fluor® 594

sc-376087 AF594
200 µg/ml
$357.00

Gas6 抗体 (A-9) Alexa Fluor® 647

sc-376087 AF647
200 µg/ml
$357.00

Gas6 抗体 (A-9) Alexa Fluor® 680

sc-376087 AF680
200 µg/ml
$357.00

Gas6 抗体 (A-9) Alexa Fluor® 790

sc-376087 AF790
200 µg/ml
$357.00

想问一下,这个小鼠源的抗体,能做大鼠或者小鼠组织的Western和免疫组化吗,谢谢!

Asked by: yang200214yy
Thank you for your question. Gas6 Antibody (A-9) is recommended for detection of Gas6 of human origin,We have not yet tested this antibody on mouse and rat origin.So the antibody is not recommended for mouse and rat sample at this time. 感谢您的提问。 Gas6 (A-9) 推荐检测人来源样本,未在大小鼠样本中做过相关验证,因此不推荐检测大小鼠实验样本。
Answered by: Technical Support 9
Date published: 2019-07-19

Is this Anti Gas6 Antibody ( (A-9): sc-376087) cross reactive with both human and mouse one?

Asked by: Nicki
Thank you for your question. Gas6 Antibody (A-9): sc-376087 is recommended for detection of Gas6 of human origin by WB, IP, IF and ELISA. It is not recommended for detection of Gas6 of murine origin, however, we cannot exclude cross-reactivity with murine samples. For further information, please contact our technical service directly.
Answered by: Tech Support Europe
Date published: 2019-05-08

Would this antibody be good for Neutralizing Gas6 from conditioned media from mouse cells?

Asked by: Nickhj89
Thank you for your question. This antibody has not been tested in any neutralizing research application.
Answered by: Technical Support
Date published: 2019-04-13

What is the recommended starting dilution for Western blot for sc-376087: Gas6 (A-9) monoclonal antibody?

Asked by: Cweed
The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, is available in the recommended protocol: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
Answered by: Technical Support
Date published: 2017-03-22
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Rated 5 out of 5 by from excellent in WBWB in conditioned medium of MDA cells 1:1000 dilution Stron and specific band
Date published: 2019-10-04
Rated 5 out of 5 by from This antibody works great for WBA single clear band between 50 - 75 kDa in immunoblot can be detected by this antibody.
Date published: 2018-04-12
Rated 4 out of 5 by from Worked wellI ran my sample on a 10% gel with a 1:300 dilution and a 1:5000 secondary dilution. Came out clean after a 4th wash, nothing non-specific.
Date published: 2017-10-10
Rated 5 out of 5 by from Works great!Found this antibody to work great at a 1:1000. Will be using it from now on. Thanks!
Date published: 2017-08-24
Rated 5 out of 5 by from 之前听同事推荐使用贵公司抗体我现在在研究炎症相关的蛋白以及生长因子,是经同学推荐使用贵公司的抗体,同学说贵公司的抗体效果不错,所以想先尝试一下,如果用的好就买,祝贵公司生意兴隆
Date published: 2017-06-23
Rated 5 out of 5 by from Solid antibody!Specific and reliable, this is a great choice for detecting Gas6, especially in Western blot.
Date published: 2017-02-02
Rated 1 out of 5 by from Cannot get bands in Western BlotCannot get bands in Western Blot
Date published: 2015-03-25
Rated 5 out of 5 by from Strong band detected in transfected cell lysatesStrong band detected in transfected cell lysates -SCBT QC
Date published: 2015-02-04
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Gas6 抗体 (A-9) is rated 4.4 out of 5 by 9.
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