Date published: 2025-9-6

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GAP1-InsP4 BP 抗体 (H-6): sc-374555

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说明书
  • GAP1-InsP4 BP抗体(H-6)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于human物种的GAP1-InsP4BP的C-terminus的氨基酸801-830之间
  • 推荐用于 mouse, rat 和 human 来源的GAP1-InsP4 BP WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP是GAP1-InsP4 BP Antibody (H-6) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与GAP1-InsP4 BP Antibody (H-6) 搭配使用(请参阅下面的订购信息)。

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    関連項目

    人类GAP1-InsP4 BP,也称为Ras p21蛋白激活剂(GTP酶激活蛋白)3 [Ins(1,3,4,5)P4-结合蛋白],是一种829个氨基酸的蛋白质,以钙依赖性和非钙依赖性方式结合磷脂。GAP1是Ras GTP酶激活蛋白家族之一,包含四个不同的基因,包括GAP1(m)、GAP1-InsP4 BP、MRASAL(小鼠Ras GTP酶激活样)和KIAA0538。该家族包含一个N末端串联C2结构域、一个GAP相关结构域和一个C末端pleckstrin同源(PH)结构域。GAP1-InsP4 BP的PH结构域对于通过结合特定磷脂靶向膜至关重要。在激动剂刺激的PtdIns(3,4,5)P(3)产生后,含有I组PH结构域的蛋白质如GAP1-InsP4 BP特异性结合肌醇磷酸盐,随后靶向质膜。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    GAP1-InsP4 BP 抗体 (H-6) 参考文献:

    1. TRAF6对hnRNPA1的泛素化将慢性先天性免疫信号与骨髓增生异常联系起来。  |  Fang, J., et al. 2017. Nat Immunol. 18: 236-245. PMID: 28024152
    2. 利用拓扑关联域揭示GWAS信号中的候选基因。  |  Way, GP., et al. 2017. Eur J Hum Genet. 25: 1286-1289. PMID: 28792001
    3. Rho GTPase-activating protein 1在缺血性心肌病模型中促进心肌细胞凋亡  |  Zhang, X., et al. 2019. Kardiol Pol. 77: 1163-1169. PMID: 31664016
    4. MiR-34b-5p通过靶向乳腺癌中的ARHGAP1抑制细胞增殖、迁移和侵袭。  |  Dong, L., et al. 2020. Am J Transl Res. 12: 269-280. PMID: 32051752
    5. 破骨细胞衍生的细胞外小泡通过抑制 ARHGAP1 诱导成骨分化  |  Liang, M., et al. 2021. Mol Ther Nucleic Acids. 23: 1191-1203. PMID: 33664997
    6. p50RhoGAP BCH结构域介导的Rho失活调控的结构基础。  |  Chichili, VPR., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34006635
    7. 细胞外小泡可预测晚期肝细胞癌放射栓塞和索拉非尼治疗的反应:来自SORAMIC试验的探索性分析。  |  Shuen, TWH., et al. 2022. Clin Cancer Res. 28: 3890-3901. PMID: 35763041
    8. 血清中miR-4488作为非酒精性脂肪肝的潜在生物标志物。  |  Shen, N., et al. 2023. Ann Transl Med. 11: 173. PMID: 36923095
    9. Rho GTPase-activating protein 1通过CircPIP5K1A/MiR-101-3p的调节剂促进肝细胞癌的进展。  |  Xu, Y., et al. 2024. Hepatol Res. 54: 174-188. PMID: 37792600
    10. CD97通过mTORC2信号传导维持胶质母细胞瘤干细胞的肿瘤特性,并被CAR Th9细胞靶向。  |  Zhou, S., et al. 2024. Cell Rep Med. 5: 101844. PMID: 39637858

    订购信息

    产品名称产品编号规格价格数量收藏夹

    GAP1-InsP4 BP 抗体 (H-6)

    sc-374555
    200 µg/ml
    RMB2377.00

    GAP1-InsP4 BP (H-6): m-IgG Fc BP-HRP 套装

    sc-540473
    200 µg Ab; 10 µg BP
    RMB2662.00

    GAP1-InsP4 BP (H-6) 中和勝肽

    sc-374555 P
    100 µg/0.5 ml
    RMB511.00

    What application is the blocking peptide sc-374555 P appropriate for?

    Asked by: TinTin
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-28
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    Rated 5 out of 5 by from Satisfactory Western Blot data of GAP1Satisfactory Western Blot data of GAP1-InsP4 BP expression in non-transfected and human GAP1-InsP4 BP transfected 293T whole cell lysates. -SCBT QC
    Date published: 2015-04-04
    Rated 5 out of 5 by from Satisfactory Western Blot data of GAP1Satisfactory Western Blot data of GAP1-InsP4 BP expression in human platelet extract. -SCBT QC
    Date published: 2014-07-05
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    GAP1-InsP 4 BP 抗体 (H-6) is rated 5.0 out of 5 by 2.
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