Date published: 2025-9-8

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γ-catenin 抗体 (11E4): sc-59986

5.0(3)
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说明书
  • γ-catenin抗体(11E4)是小鼠单克隆IgG1 κ, 在1篇文献中引用,规格为200 µg/ml
  • 免疫human物种的重组γ-catenin
  • 推荐用于 mouse, rat 和 human 来源的γ-catenin WB, IP 和 IF检测
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是γ-catenin Antibody (11E4) for WB applications. 的首选辅助检测试剂,这些试剂现与γ-catenin Antibody (11E4) 打包提供(请参阅下面的订购信息)。

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関連項目

γ-catenin 抗体 (11E4) 是一种小鼠单克隆 IgG1 抗体,可通过免疫印迹 (WB)、免疫沉淀 (IP) 和免疫荧光 (IF) 等应用检测小鼠、大鼠和人样本中的γ-catenin。γ-catenin主要位于细胞质和细胞膜上,在细胞膜上,γ-catenin与α-catenin和N-cadherin相互作用,促进组织结构的完整性并影响细胞信号通路。γ-catenin的位置对维持细胞-细胞粘附和组织结构至关重要,而细胞-细胞粘附和组织结构对器官的正常功能和发育至关重要。此外,γ-catenin 与肿瘤抑制因子 APC 等其他蛋白的相互作用突出了γ-catenin 在细胞信号传导中的作用以及在癌症生物学中的潜在影响。抗γ-catenin 抗体 (11E4) 使研究人员能够深入了解细胞粘附动力学和各种疾病的分子机制。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

γ-catenin 抗体 (11E4) 参考文献:

  1. 在非小细胞肺癌中,α-catenin、β-catenin 和 gamma-catenin 的表达减少与细胞增殖活性高和分化不良有关。  |  Pirinen, RT., et al. 2001. J Clin Pathol. 54: 391-5. PMID: 11328840
  2. Wilms 肿瘤中 gamma catenin 的免疫组化分析。  |  Basta-Jovanovic, G., et al. 2008. Fetal Pediatr Pathol. 27: 63-70. PMID: 18568994
  3. β-catenin和γ-catenin在上颌骨再生中的表达。  |  Santarelli, A., et al. 2011. Int J Immunopathol Pharmacol. 24: 107-11. PMID: 21781455
  4. γ-Catenin在急性髓性白血病中过度表达,并促进β-catenin的稳定和核定位。  |  Morgan, RG., et al. 2013. Leukemia. 27: 336-43. PMID: 22858986
  5. 口腔白斑和鳞状细胞癌中 Desmoglein-3/γ-catenin 和 E-cadherin/ß-catenin 的差异表达。  |  Kyrodimou, M., et al. 2014. Clin Oral Investig. 18: 199-210. PMID: 23430339
  6. 通过组蛋白去乙酰化酶抑制剂清除γ-catenin,与伊马替尼联用可消灭CML干细胞  |  Jin, Y., et al. 2016. Theranostics. 6: 1947-62. PMID: 27570562
  7. FBW7 通过促进 γ-catenin K63 链接泛素化来抑制细胞增殖和 G2/M 细胞周期转换。  |  Li, Y., et al. 2018. Biochem Biophys Res Commun. 497: 473-479. PMID: 29408378
  8. 肝细胞中β-Catenin和γ-Catenin的双重缺失通过转化生长因子-β和肝细胞核因子4α信号的改变影响其极性。  |  Pradhan-Sundd, T., et al. 2021. Am J Pathol. 191: 885-901. PMID: 33662348
  9. 上皮肿瘤细胞系中 beta-catenin 和 gamma-catenin 的表达以及一种独特细胞系的特征。  |  Lipschutz, JH. and Kissil, JL. 1998. Cancer Lett. 126: 33-41. PMID: 9563646
  10. 人肺癌中 e-cadherin、α-catenin 和 gamma-catenin 的表达减少,而 beta-catenin 却没有减少。  |  Toyoyama, H., et al. 1999. Oncol Rep. 6: 81-5. PMID: 9864406

订购信息

产品名称产品编号规格价格数量收藏夹

γ-catenin 抗体 (11E4)

sc-59986
200 µg/ml
RMB2377.00

γ-catenin (11E4): m-IgG Fc BP-HRP 套装

sc-539156
200 µg Ab; 10 µg BP
RMB2662.00

γ-catenin (11E4): m-IgG1 BP-HRP 套装

sc-541298
200 µg Ab; 20 µg BP
RMB2662.00

Are there any issues with using sc-59986: γ-catenin (11E4) mouse monoclonal primary antibody on mouse samples?

Asked by: cjMara
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-59986 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by from Worked with humanWorked with human -catenin transfected 293T and A-431 whole cell lysates by WB. -SCBT QC
Date published: 2015-02-05
Rated 5 out of 5 by from Good specificity for WB in nonGood specificity for WB in non-transfected 293T, mouse -catenin transfected 293T(B) and HeLa (C) whole cell lysates. -SCBT QC
Date published: 2015-01-23
Rated 5 out of 5 by from Single Strong band for WB in Jurkat (A)Single Strong band for WB in Jurkat (A), HT-1080 (B) and H4 (C) whole cell lysates. -SCBT QC
Date published: 2014-11-15
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γ-catenin 抗体 (11E4) is rated 5.0 out of 5 by 3.
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