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galectin-1 Antibody (C-8) - Western Blotting - Image 65654
galectin-1 抗体 (C-8): sc-166618. HeLa (A), NIH/3T3 (B) 和 KNRK (C) 全细胞裂解液中 galectin-1 表达的 Western 印迹分析.
galectin-1 抗体 (C-8): sc-166618. HeLa (A), NIH/3T3 (B) 和 KNRK (C) 全细胞裂解液中 galectin-1 表达的 Western 印迹分析.

galectin-1 抗体 (C-8): sc-166618

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说明书
  • galectin-1 抗体 C-8 是小鼠单克隆 IgG2a κ，galectin-1抗体, 在26篇文献中引用，规格为200 µg/ml
  • 针对氨基酸1-45的抗原，在galectin-1的N-terminus处映射，human来源
  • galectin-1 抗体 (C-8) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 galectin-1
  • 抗galectin-1抗体（C-8）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取galectin-1 (C-8): sc-166618的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG2a BP-HRP 是 galectin-1 抗体 (C-8) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与galectin-1 抗体 (C-8) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

附加galectin抗体，包括galectin-1, galectin-10, galectin-2, galectin-3, galectin-4, galectin-5, galectin-7和galectin-8

半乳凝素-1抗体（C-8）是一种IgG2a κ小鼠单克隆半乳凝素-1抗体（也称为LGALS1抗体、半乳凝素-1抗体或Gal-1抗体），可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人源的半乳凝素-1蛋白。半乳凝素-1抗体（C-8）既可作为非偶联的抗半乳凝素-1抗体形式，也可作为多种偶联形式的抗半乳凝素-1抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。半乳凝素是一个可溶性β-半乳糖苷结合动物凝集素家族，可调节细胞间粘附和细胞与细胞外基质（ECM）相互作用，并在肿瘤进展、mRNA前体剪接和凋亡中发挥作用。具体而言，半乳凝素-1是细胞增殖的自身调节因子，在维持G0期和调控G2期中发挥作用。半乳凝素-1也称为LGALS1，是与人类染色体22q13.1相连的单个基因的蛋白产物。半乳凝素-1蛋白包含135个氨基酸、一个单一的内EcoRI位点和聚腺苷酸化信号。半乳凝素-1可以定位于细胞内和细胞外空间。半乳凝素-1在人胎盘、人肺、HL-6、HepG2和CEM细胞中表达。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

galectin-1 抗体 (C-8) 参考文献:

  1. 肝内胆管癌中内源性 galectin-1 和 galectin-3 的表达。  |  Shimonishi, T., et al. 2001. Hum Pathol. 32: 302-10. PMID: 11274640
  2. 分离出编码人 beta-半乳糖苷结合蛋白的 cDNA 克隆，该蛋白在糖皮质激素诱导的细胞死亡过程中过度表达。  |  Goldstone, SD. and Lavin, MF. 1991. Biochem Biophys Res Commun. 178: 746-50. PMID: 1713454
  3. Galectin-1将肿瘤缺氧与放射治疗联系起来。  |  Kuo, P. and Le, QT. 2014. Glycobiology. 24: 921-5. PMID: 24973253
  4. Galectin-1抑制剂及其潜在治疗应用：专利审查。  |  Blanchard, H., et al. 2016. Expert Opin Ther Pat. 26: 537-54. PMID: 26950805
  5. 人类 14 kDa 可溶性 beta-半乳糖苷结合凝集素由单一基因编码的证据。  |  Abbott, WM. and Feizi, T. 1989. Biochem J. 259: 291-4. PMID: 2719646
  6. 人 14 kDa β-半乳糖苷结合凝集素全长 cDNA 的克隆和核苷酸序列。  |  Hirabayashi, J., et al. 1989. Biochim Biophys Acta. 1008: 85-91. PMID: 2719964
  7. 人类 14-kDa 凝集素的分子克隆, 表征和表达。  |  Couraud, PO., et al. 1989. J Biol Chem. 264: 1310-6. PMID: 2910856
  8. 半乳糖凝集素-1和半乳糖凝集素-3在自身免疫性疾病中的治疗潜力。  |  He, YS., et al. 2022. Curr Pharm Des. 28: 36-45. PMID: 34579628
  9. Galectin-1在肿瘤微环境中的免疫抑制作用。  |  Huang, Y., et al. 2021. Biomolecules. 11: PMID: 34680031
  10. Galectin-1介导的MET/AXL信号传导通过逃避铁死亡增强肝细胞癌对索拉非尼的耐药性。  |  Hsu, TW., et al. 2023. Aging (Albany NY). 15: 6503-6525. PMID: 37433225
  11. 绘制人类和小鼠染色体上的β-半乳糖苷结合蛋白基因图谱，这是一种自分泌阴性生长因子。  |  Baldini, A., et al. 1993. Genomics. 15: 216-8. PMID: 8432540
  12. S-lac 凝集素基因家族的两个成员 LGALS1 和 LGALS2 位于人类染色体 22q12-q13 附近。  |  Mehrabian, M., et al. 1993. Genomics. 15: 418-20. PMID: 8449510

订购信息

产品名称产品编号规格价格数量收藏夹

galectin-1 抗体 (C-8)

sc-166618
200 µg/ml
RMB2377.00

galectin-1 (C-8): m-IgG Fc BP-HRP 套装

sc-525765
200 µg Ab; 10 µg BP
RMB2662.00

galectin-1 (C-8): m-IgG2a BP-HRP 套装

sc-546405
200 µg Ab; 10 µg BP
RMB2662.00

galectin-1 抗体 (C-8) AC

sc-166618 AC
500 µg/ml, 25% agarose
RMB3129.00

galectin-1 抗体 (C-8) HRP

sc-166618 HRP
200 µg/ml
RMB2377.00

galectin-1 抗体 (C-8) FITC

sc-166618 FITC
200 µg/ml
RMB2482.00

galectin-1 抗体 (C-8) PE

sc-166618 PE
200 µg/ml
RMB2580.00

galectin-1 抗体 (C-8) Alexa Fluor® 488

sc-166618 AF488
200 µg/ml
RMB2685.00

galectin-1 抗体 (C-8) Alexa Fluor® 546

sc-166618 AF546
200 µg/ml
RMB2685.00

galectin-1 抗体 (C-8) Alexa Fluor® 594

sc-166618 AF594
200 µg/ml
RMB2685.00

galectin-1 抗体 (C-8) Alexa Fluor® 647

sc-166618 AF647
200 µg/ml
RMB2685.00

galectin-1 抗体 (C-8) Alexa Fluor® 680

sc-166618 AF680
200 µg/ml
RMB2685.00

galectin-1 抗体 (C-8) Alexa Fluor® 790

sc-166618 AF790
200 µg/ml
RMB2685.00

Dear Sirs, I am interesting for anti-galectin-1 antibody (raised in mouse, against human galectin-1) as detecting antibody for ELISA for human sera samples. Which one of your antibodies will you recommend for this purpose? Thanks in advance, Danica

Asked by: Danica
Thank you for your question. Yes, this antibody, galectin-1 (C-8) sc-166618, is a great choice for ELISA use. It is human reactive and will be a good choice for your application.
Answered by: Tech Service
Date published: 2019-10-02

I am thinking about using this antibody for a double stain. Do you have any suggestions for doing this with only mouse monoclonal antibodies?

Asked by: Cweed
We recommend using directly conjugated antibodies. This product, sc-166618, is available conjugated to FITC, AF488, and AF647.
Answered by: Technical Support 9
Date published: 2017-01-20
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Rated 5 out of 5 by from Clear and high signalI tested a sample and work really well with an ARPE-19 cell extract. Dil 1/200, ON incubation. Conjugated secondary antibody.
Date published: 2017-08-30
Rated 5 out of 5 by from SuperbVery strong , clear western blot data; also great IHC staining
Date published: 2017-02-03
Rated 5 out of 5 by from Reliable and specificChoosing this antibody for galectin-1 studies is a smart choice. It gives nice strong bands in WB, and we see consistent specific staining in IHC.
Date published: 2016-12-16
Rated 5 out of 5 by from Exceptional immunoperoxidase nuclear andExceptional immunoperoxidase nuclear and cytoplasmic staining in formalin fixed, paraffin-embedded human tonsil tissue. -SCBT QC
Date published: 2015-05-10
Rated 5 out of 5 by from StrongStrong, circular band seen in WB in HeLa, NIH/3T3 and KNRK whole cell lysates. -SCBT QC
Date published: 2015-03-13
Rated 5 out of 5 by from Publishable data for IHC(P) and WB in humanPublishable data for IHC(P) and WB in human Pancreatic cancer tissue. -SCBT Publication Review
Date published: 2015-02-26
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galectin-1 抗体 (C-8) is rated 5.0 out of 5 by 6.
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