Date published: 2025-9-8
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GABARAP Antibody (E-8) - Western Blotting - Image 359181
GABARAP 抗体 (E-8): sc-377300. HeLa (A), Jurkat (B) 和 NIH/3T3 (C) 全细胞裂解液中 GABARAP 表达的 Western 印迹分析.
GABARAP Antibody (E-8) - Western Blotting - Image 359181
GABARAP 抗体 (E-8): sc-377300. HeLa (A), Jurkat (B) 和 NIH/3T3 (C) 全细胞裂解液中 GABARAP 表达的 Western 印迹分析.
GABARAP Antibody (E-8) - Western Blotting - Image 283459
GABARAP 抗体 (E-8): sc-377300. HeLa (A) 和 MIA PaCa-2 (B) 全细胞裂解液中 GABARAP 表达的 Western 印迹分析.
GABARAP Antibody (E-8) - Western Blotting - Image 362217
GABARAP 抗体 (E-8): sc-377300. SH-SY5Y (A) 和 U-87 MG (B) 全细胞裂解液中 GABARAP 表达的 Western 印迹分析.
GABARAP 抗体 (E-8): sc-377300. HeLa (A), Jurkat (B) 和 NIH/3T3 (C) 全细胞裂解液中 GABARAP 表达的 Western 印迹分析.

GABARAP 抗体 (E-8): sc-377300

4.8(6)
寫評論提問

说明书
  • GABARAP 抗体 E-8 是小鼠单克隆 IgG1 κ，GABARAP抗体, 在7篇文献中引用，规格为200 µg/ml
  • 免疫human物种的代表全长GABARAP的氨基酸1-117
  • GABARAP 抗体 (E-8) 推荐用于 WB, IP, IF 和 ELISA，检测mouse, rat 和human 来源的 GABARAP and GABARAPL1; 也和以下物种反应，包括： 和 canine, bovine and porcine
  • 抗GABARAP抗体（E-8）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取GABARAP (E-8): sc-377300的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP和 1 BP-HRP">m-IgG1 BP-HRP是GABARAP Antibody (E-8) for WB applications. 的首选辅助检测试剂，这些试剂现与GABARAP Antibody (E-8) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

GABARAP抗体（E-8）是一种IgG1 κ小鼠单克隆GABARAP抗体（也称为GABARAP抗体），可通过WB, IP, IF 和 ELISA检测小鼠、大鼠和人类来源的GABARAP蛋白和GABARAPL1蛋白。GABARAP抗体（E-8）既有非偶联的抗GABARAP抗体形式，也有多种偶联形式的抗GABARAP抗体，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®偶联物。在中枢神经系统中，GABA通过增加抑制神经元放电的Cl-电导来发挥主要的抑制性递质作用。已显示GABA能激活离子型（GABAA）和代谢型（GABAB）受体，以及第三类称为GABAC的受体。除了GABA受体外，已发现几种蛋白质作为GABA功能的调节剂，包括GAD65、GAD67、GABA转运蛋白和GABARAP（GABAA受体相关蛋白）。GABARAP与GABAA Rg2结合，将GABAA受体与细胞骨架连接起来。GABARAP蛋白序列与微管相关蛋白（MAPs）的轻链-3相似，这表明它可能是一种MAP或MAP复合物的组分。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

GABARAP 抗体 (E-8) 参考文献:

  1. GABA：出生后早期的兴奋性递质。  |  Cherubini, E., et al. 1991. Trends Neurosci. 14: 515-9. PMID: 1726341
  2. GABARAP-配体相互作用的结构特征。  |  Thielmann, Y., et al. 2009. Mol Biosyst. 5: 575-9. PMID: 19462014
  3. 揭示人类 ATG4 蛋白酶同工酶在细胞自噬和 LC3/GABARAP 处理过程中的冗余性。  |  Agrotis, A., et al. 2019. Autophagy. 15: 976-997. PMID: 30661429
  4. TNIP1 通过与 LC3/GABARAP 和 TAX1BP1 的双向相互作用抑制选择性自噬。  |  Le Guerroué, F., et al. 2023. Mol Cell. 83: 927-941.e8. PMID: 36898370
  5. ATG4B 通过 GABARAP 引导的 TBK1 自噬降解来拮抗抗病毒免疫。  |  Xie, W., et al. 2023. Autophagy. 19: 2853-2868. PMID: 37434364
  6. 非典型的GABARAP结合模块可驱动AML相关NPM1c变体的自噬潜能。  |  Mende, H., et al. 2023. Cell Rep. 42: 113484. PMID: 37999976
  7. GABARAP的缺失可导致多发性骨髓瘤对免疫原性化疗产生抗药性。  |  Gulla, A., et al. 2024. Blood. 143: 2612-2626. PMID: 38551812
  8. 谷氨酸脱羧酶 67 kDa 异构体与谷氨酸脱羧酶 65 kDa 异构体的 NH2 端区域相互作用，从而使谷氨酸脱羧酶 67 kDa 异构体靶向细胞内器官。  |  Dirkx, R., et al. 1995. J Biol Chem. 270: 2241-6. PMID: 7836456
  9. 脊椎动物视网膜中的 GABAC 受体。  |  Lukasiewicz, PD. 1996. Mol Neurobiol. 12: 181-94. PMID: 8884747
  10. GABA 转运体的异质性：药理学和细胞定位。  |  Borden, LA. 1996. Neurochem Int. 29: 335-56. PMID: 8939442
  11. 人类γ-氨基丁酸B型受体以不同方式表达并调节内向整流K+通道。  |  Kaupmann, K., et al. 1998. Proc Natl Acad Sci U S A. 95: 14991-6. PMID: 9844003
  12. 连接 GABA（A）受体和细胞骨架的 GABA（A）受体相关蛋白。  |  Wang, H., et al. 1999. Nature. 397: 69-72. PMID: 9892355

订购信息

产品名称产品编号规格价格数量收藏夹

GABARAP 抗体 (E-8)

sc-377300
200 µg/ml
RMB2377.00

GABARAP (E-8): m-IgG Fc BP-HRP 套装

sc-527594
200 µg Ab; 10 µg BP
RMB2662.00

GABARAP (E-8): m-IgG1 BP-HRP 套装

sc-532967
200 µg Ab; 20 µg BP
RMB2662.00

GABARAP 抗体 (E-8) AC

sc-377300 AC
500 µg/ml, 25% agarose
RMB3129.00

GABARAP 抗体 (E-8) HRP

sc-377300 HRP
200 µg/ml
RMB2377.00

GABARAP 抗体 (E-8) FITC

sc-377300 FITC
200 µg/ml
RMB2482.00

GABARAP 抗体 (E-8) PE

sc-377300 PE
200 µg/ml
RMB2580.00

GABARAP 抗体 (E-8) Alexa Fluor® 488

sc-377300 AF488
200 µg/ml
RMB2685.00

GABARAP 抗体 (E-8) Alexa Fluor® 546

sc-377300 AF546
200 µg/ml
RMB2685.00

GABARAP 抗体 (E-8) Alexa Fluor® 594

sc-377300 AF594
200 µg/ml
RMB2685.00

GABARAP 抗体 (E-8) Alexa Fluor® 647

sc-377300 AF647
200 µg/ml
RMB2685.00

GABARAP 抗体 (E-8) Alexa Fluor® 680

sc-377300 AF680
200 µg/ml
RMB2685.00

GABARAP 抗体 (E-8) Alexa Fluor® 790

sc-377300 AF790
200 µg/ml
RMB2685.00

Is GABARAP Antibody (E-8) Alexa Fluor® 647 a special secondary antibody for GABARAP Antibody (E-8)? Is it different with the Alexa Fluor 647 we usually use?

Asked by: Shuntong
Thank you for your question. This antibody, sc-377300 GABARAP Antibody (E-8), is a primary antibody against GABARAP. The Alexa Fluor conjugated form, sc-377300 AF647, is the same primary antibody conjugated to AF647. It is not a secondary antibody and can not replace any other antibody. You do not need to use a secondary antibody if you use this conjugated form of the primary antibody. If you have any further questions, please contact Technical Service.
Answered by: Tech Service
Date published: 2019-11-19

Whether GABARAP 抗体 (E-8): sc-377300 could be used to detect the GABARAPL1 ?

Asked by: Xingyu
Thank you for your question. Yes, this antibody is GABARAP and GABARAPL1 reactive.
Answered by: Tech Service
Date published: 2019-04-15

Are there any issues with using sc-377300: GABARAP (E-8) mouse monoclonal primary antibody on mouse samples?

Asked by: Randy McDonald
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-377300 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by from 非常好用买了之后，做的效果很好。再也不怕微笑脸了。santacurz 性价比高，货期短，比起动辄4周起的thermo好太多
Date published: 2022-03-07
Rated 5 out of 5 by from 非常好用买了之后，做的效果很好。再也不怕微笑脸了。santacurz 性价比高，货期短，比起动辄4周起的thermo好太多
Date published: 2022-03-07
Rated 5 out of 5 by from works well in WBThis antibody worked well in WB in human fibroblasts.
Date published: 2018-06-06
Rated 4 out of 5 by from GABARAP antibody and the retinaLower vertebrate retina is an useful model of the brain. In our Lab we are studing for years immunocytochemically and electrophysiologically the GABAergic neurotransmision in frog and turtle retinae. Recently we applied on the retina the GABARAP antibody (E-8) and were happy to reveal that it causes well expressed staining on it. Both plexiform layers - the outer (OPL) and the inner one (IPL), were very well visualized, and some amacrine (A), bipolar (B) and ganglion (G) cells bodies as well. GABARAP antibody immunoreactivity colocalized with the GABAA receptor gamma subunit. No collocalizations were found with the rho subunits of GABAA receptor.
Date published: 2018-01-10
Rated 5 out of 5 by from positive western blot resultsWe used this antibody for a western blot experiment and got positive bands in HeLa cells
Date published: 2017-01-18
Rated 5 out of 5 by from Produced positive Western blot data of GABARAPProduced positive Western blot data of GABARAP expression in HeLa and MIA PaCa-2 whole cell lysates. -SCBT QC
Date published: 2013-04-07
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GABARAP 抗体 (E-8) is rated 4.8 out of 5 by 6.
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