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GABA<sub>A</sub> R&alpha;1-6 Antibody (E-8) - Western Blotting - Image 299283
GABAA Rα1-6 (E-8): sc-376282. 小鼠脑组织提取物中 GABAA Rα1-6 表达的 Western 印迹分析.
GABAA Rα1-6 (E-8): sc-376282. 小鼠脑组织提取物中 GABAA Rα1-6 表达的 Western 印迹分析.

GABAA Rα1-6 抗体 (E-8): sc-376282

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寫評論提問

说明书
  • GABAA R alpha 1-6 抗体 E-8 是小鼠单克隆 IgG1 κ，GABAA Rα1-6抗体, 在14篇文献中引用，规格为200 µg/ml
  • 免疫原氨基酸序列157-456位于human物种的GABAA Rα1的C-terminus附近
  • GABAA R alpha 1-6 抗体 (E-8) 推荐用于 WB, IP, IF 和 ELISA，检测mouse, rat 和human 来源的 GABAA Rα1, GABAA Rα2, GABAA Rα3, GABAA Rα4, GABAA Rα5 and GABAA Rα6; 也和以下物种反应，包括： 和 equine, canine, bovine and porcine
  • 抗GABAA R alpha 1-6抗体（E-8）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取GABAA Rα1-6 (E-8): sc-376282的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP和 1 BP-HRP">m-IgG1 BP-HRP是GABAA Rα1-6 Antibody (E-8) for WB applications. 的首选辅助检测试剂，这些试剂现与GABAA Rα1-6 Antibody (E-8) 打包提供（请参阅下面的订购信息）。

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相关产品
描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

附加GABA Receptor抗体，包括GABAA R α 1, GABAA R α 5, GABAA R β 3, GABAA R δ, GABAA R ε, GABAB R1, GABAB R1 α和GABAB R2

GABAA Rα1-6抗体（E-8）是一种IgG1 κ小鼠单克隆GABAA R alpha 1-6抗体（也称为GABRA1抗体、GBRA1抗体、Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha 1抗体、GABA(A) Receptor Subunit Alpha-1抗体、GABA(A) Receptor Alpha 1抗体、EJM5抗体、Gamma-Aminobutyric Acid Type A Receptor Alpha Subunit抗体、GABRA1抗体、ECA4抗体或EJM抗体），可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的GABAA R alpha 1-6蛋白。GABAA Rα1-6抗体（E-8）既有非偶联型抗GABAA R alpha 1-6抗体形式，也有多种偶联型抗GABAA R alpha 1-6抗体形式，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。谷氨酸脱羧酶GAD-65和GAD-67的功能是催化GABA（γ-氨基丁酸）的产生。在中枢神经系统中，GABA通过增加Cl-电导来抑制神经元放电，从而作为主要的抑制性递质发挥作用。GABA已被证明可以激活离子型（GABAA）和代谢型（GABAB）受体，以及第三类称为GABAC的受体。GABAA和GABAC都是配体门控离子通道，但它们在结构和功能上有所不同。GABAA受体家族成员包括GABAA Rα1-6、GABAA R β1-3、GABAA Rγ1-3、GABAA Rδ、GABAA Rε、GABAA Rρ1和GABAA Rρ2。GABAB家族由GABAB R1α和GABAB R1β组成。还已确定存在GABA转运蛋白，包括GABA T-1、GABA T-2和GABA T-3（也称为GAT-1、-2和-3）。GABA转运蛋白的功能是终止GABA的作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

GABAA Rα1-6 抗体 (E-8) 参考文献:

  1. γ-氨基丁酸（GABA）转运系统的分子异质性。从大鼠大脑中克隆出两种新型高亲和力 GABA 转运体。  |  Borden, LA., et al. 1992. J Biol Chem. 267: 21098-104. PMID: 1400419
  2. GABA：出生后早期的兴奋性递质。  |  Cherubini, E., et al. 1991. Trends Neurosci. 14: 515-9. PMID: 1726341
  3. 克隆人脑 GABA 转运体。  |  Nelson, H., et al. 1990. FEBS Lett. 269: 181-4. PMID: 2387399
  4. 谷氨酸脱羧酶 67 kDa 异构体与谷氨酸脱羧酶 65 kDa 异构体的 NH2 端区域相互作用，从而使谷氨酸脱羧酶 67 kDa 异构体靶向细胞内器官。  |  Dirkx, R., et al. 1995. J Biol Chem. 270: 2241-6. PMID: 7836456
  5. 脊椎动物视网膜中的 GABAC 受体。  |  Lukasiewicz, PD. 1996. Mol Neurobiol. 12: 181-94. PMID: 8884747
  6. GABA（B）受体的表达克隆发现了其与代谢型谷氨酸受体的相似性。  |  Kaupmann, K., et al. 1997. Nature. 386: 239-46. PMID: 9069281
  7. GABA（A）受体亚型：苯并二氮杂卓部位配体的临床疗效和选择性。  |  Korpi, ER., et al. 1997. Ann Med. 29: 275-82. PMID: 9375983

订购信息

产品名称产品编号规格价格数量收藏夹

GABAA Rα1-6 抗体 (E-8)

sc-376282
200 µg/ml
RMB2377.00

GABAA Rα1-6 (E-8): m-IgG Fc BP-HRP 套装

sc-527520
200 µg Ab; 10 µg BP
RMB2662.00

GABAA Rα1-6 (E-8): m-IgG1 BP-HRP 套装

sc-532893
200 µg Ab; 20 µg BP
RMB2662.00

GABAA Rα1-6 抗体 (E-8) AC

sc-376282 AC
500 µg/ml, 25% agarose
RMB3129.00

GABAA Rα1-6 抗体 (E-8) HRP

sc-376282 HRP
200 µg/ml
RMB2377.00

GABAA Rα1-6 抗体 (E-8) FITC

sc-376282 FITC
200 µg/ml
RMB2482.00

GABAA Rα1-6 抗体 (E-8) PE

sc-376282 PE
200 µg/ml
RMB2580.00

GABAA Rα1-6 抗体 (E-8) Alexa Fluor® 488

sc-376282 AF488
200 µg/ml
RMB2685.00

GABAA Rα1-6 抗体 (E-8) Alexa Fluor® 546

sc-376282 AF546
200 µg/ml
RMB2685.00

GABAA Rα1-6 抗体 (E-8) Alexa Fluor® 594

sc-376282 AF594
200 µg/ml
RMB2685.00

GABAA Rα1-6 抗体 (E-8) Alexa Fluor® 647

sc-376282 AF647
200 µg/ml
RMB2685.00

GABAA Rα1-6 抗体 (E-8) Alexa Fluor® 680

sc-376282 AF680
200 µg/ml
RMB2685.00

GABAA Rα1-6 抗体 (E-8) Alexa Fluor® 790

sc-376282 AF790
200 µg/ml
RMB2685.00

Can GABAA R&alpha;1-6 (E-8): sc-376282 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: TinTin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, GABAA R&alpha;1-6 (E-8): sc-376282 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 1 out of 5 by from further tests neededIt didn't work on our neuron culture. We will do further tests
Date published: 2022-01-14
Rated 1 out of 5 by from IF not work.Test IF with this antibody on both embryonic and early postnatal mouse brain tissue. No specific signal could be detected.
Date published: 2019-03-15
Rated 4 out of 5 by from Worked wellAnalysis of GABAA Rα1-6 from P90 mouse hippocampus lysate. Mouse anti-GABAA Rα1-6 (E-8) sc-376282 was diluted 1:500 in TBS 1x containing 5% skimmed milk and 0,2% Tween-20. Anti-mouse HRP-conjugated secondary antibody was diluted 1:10000.
Date published: 2018-04-16
Rated 3 out of 5 by from Might working antibodyThis antibody might work in WB with mouse hippocampus tissue.
Date published: 2017-10-18
Rated 5 out of 5 by from Great AB!This antibody worked very well for my ICC staining of differentiated human iPSCs.
Date published: 2017-09-26
Rated 5 out of 5 by from Work well in WBI applied the antibody at 1:300 in WB, PC12 cells. The obtained protein bands are clear. There was no other bands appearness. I used the 12% separation gel in my experiment.
Date published: 2017-09-18
Rated 5 out of 5 by from Great antibody, strong WBGABAA Rα1-6 (E-8) gave a beautiful Western blot (WB) band in mouse brain tissue extract at 51 kDa.
Date published: 2017-02-03
Rated 5 out of 5 by from Great Western Blot data of GABAA R 1Great Western Blot data of GABAA R 1-6 expression in mouse brain tissue extract. -SCBT QC
Date published: 2015-05-17
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GABA A Rα1-6 抗体 (E-8) is rated 3.8 out of 5 by 9.
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