Fluconazole CAS: 86386-73-4
MF: C13H12F2N6O
MW: 306.27
A triazole broad-spectrum antifungal agent particularly for candida species.

Fluconazole (CAS 86386-73-4)

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Alternate Names: a-(2,4-Difluorophenyl)-a-(1H-1,2,4-triazol-1- ylmethyl)-1H-1,2,4-triazole-1-ethanol
Application: Fluconazole is a triazole broad-spectrum antifungal agent particularly for candida species
CAS Number: 86386-73-4
Purity: ≥98%
Molecular Weight: 306.27
Molecular Formula: C13H12F2N6O
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Fluconazole is a triazole broad-spectrum antifungal agent which is effective against Candida spp., cryptococcus neoformans and dermatophytes. Fluconazole is an inhibitor of CYP2C19, CYP2C9 and CYP3A4.


参考文献

1. Vincent-Ballereau, F.N., et al. 1991. Pharm. Weekbl. Sci. 13: 45-57. PMID: 1870943
2. Martin, M.V. 1999. J. Antimicrob Chemother. 44: 429-437. PMID: 10588302

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (<1 mg/ml at 25° C), ethanol (61 mg/ml at 25° C), and DMSO (61 mg/ml at 25° C).
Storage :
Store at room temperature
Melting Point :
138-142° C
Boiling Point :
~579.8° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
CYP51A1: IC50 = 0.13 µM (human); Candida albicans: IC50 = 0.30 µM; Candida parapsilosis: IC50 = 0.69 µM; Cryptococcus neoformans: IC50 = 1.47 µM; Trichophyton mentagrophytes: IC50 = 1.96 µM
Ki Data :
Mdr-1: Ki>0.4 mM (human); P-glycoprotein 1: Ki>1 mM (mouse); P-glycoprotein 3: Ki>1 mM (mouse)
pK Values :
pKa: 11.01 (Predicted), pKb: 2.94 (Predicted)
仅供科研使用。不可用于诊断或治疗。
WGK Germany :
3
RTECS :
XZ4810000
PubChem CID :
3365
Merck Index :
14: 4122
MDL Number :
MFCD00274549
SMILES :
C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O

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Citations 1 to 1 of 1 total

PMID: # 22851130  Gillies, AT. et al. 2012. Molecular bioSystems. 8: 2901-8.

Citations 1 to 1 of 1 total
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