Date published: 2025-9-6

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Fibronectin Inhibitor 抑制剂 (CAS 91037-65-9)

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查看产品引用文献(3)

备用名:
Fibronectin tetrapeptide; H-Arg-Gly-Asp-Ser-OH
应用:
Fibronectin Inhibitor 是一种支持成纤维细胞附着并抑制纤连蛋白结合的四肽
CAS号码:
91037-65-9
纯度:
≥97%
分子量:
433.40
分子式:
C15H27N7O8
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

快捷链接

Fibronectin Inhibitor(纤连蛋白抑制剂)是一个四肽,它既有助于成纤维细胞的附着,也能抑制纤连蛋白与血小板的结合。此外,它是一个整合素结合序列,能够抑制整合素受体的功能。研究已证实,它可以通过抑制胶原蛋白触发的白细胞活化来减少全身性炎症,并且可以减弱炎性细胞因子iNOS和MMP-9的表达。另外,它也被证实可以促进细胞附着,并可以通过成骨细胞中的线粒体途径来消除凋亡。众所周知,它是梅毒螺旋体粘附的目标序列。


Fibronectin Inhibitor 抑制剂 (CAS 91037-65-9) 参考文献

  1. 骨骼细胞凋亡的基质调控 II:含 Arg-Gly-Asp 肽的作用。  |  Perlot, RL., et al. 2002. J Bone Miner Res. 17: 66-76. PMID: 11771671
  2. 成骨细胞样细胞的凋亡和存活受表面附着物的调控。  |  Grigoriou, V., et al. 2005. J Biol Chem. 280: 1733-9. PMID: 15522882
  3. 合成 RGDS 肽通过抑制整合素信号 MAP 激酶通路减轻脂多糖诱发的肺部炎症。  |  Moon, C., et al. 2009. Respir Res. 10: 18. PMID: 19272161
  4. 基质金属蛋白酶-2缺陷的成纤维细胞对结缔组织生长因子/CCN2的纤维化反应发生了改变,因为内源性纤连蛋白的水平增加了。  |  Droppelmann, CA., et al. 2009. J Biol Chem. 284: 13551-13561. PMID: 19276073
  5. 纤连蛋白是血流诱导血管重塑的重要调节因子。  |  Chiang, HY., et al. 2009. Arterioscler Thromb Vasc Biol. 29: 1074-9. PMID: 19407246
  6. 纤维粘连蛋白在鲍曼不动杆菌粘附宿主细胞中的作用。  |  Smani, Y., et al. 2012. PLoS One. 7: e33073. PMID: 22514602
  7. 从纤维粘连蛋白的细胞结合结构域提取的合成四肽抑制血小板粘附到纤维粘连蛋白, 纤维蛋白原和 von Willebrand 因子底物上。  |  Haverstick, DM., et al. 1985. Blood. 66: 946-52. PMID: 3876125
  8. 纤连蛋白四肽是梅毒螺旋体细胞粘附的靶标。  |  Thomas, DD., et al. 1985. J Exp Med. 162: 1715-9. PMID: 3903025
  9. 通过支持成纤维细胞黏合剂的蛋白水解片段和合成肽抑制纤维连接蛋白与血小板的结合。  |  Ginsberg, M., et al. 1985. J Biol Chem. 260: 3931-6. PMID: 3980461
  10. 纤连蛋白的细胞附着活性可以通过小分子合成片段复制。  |  Pierschbacher, MD. and Ruoslahti, E. Nature. 309: 30-3. PMID: 6325925

订购信息

产品名称产品编号规格价格数量收藏夹

Fibronectin Inhibitor, 25 mg

sc-202156
25 mg
RMB2189.00

Hello, would you be able to tell me if the Fibronectin Inhibitor (CAS 91037-65-9) has been tested in mice in vivo? Many thanks, Emily

Asked by: ejh99
Thank you for your question. All of our products are exclusively intended for in vitro research use and have not been tested in vivo.
Answered by: Tech Support Europe
Date published: 2023-09-25

Hello, I want to buy a mouse fibronectin inhibitor. I think the one available in the website is Fibronectin Inhibidor (CAS 91037-65-9), does it only inhibit human fibronectin? Are there some analyses performing its effect on mouse fibronectin? thanks

Asked by: Luna Sánchez
Thank you for your message. You can check for further details the publications related to this product: 1. Pierschbacher, M.D., et al. 1984. Nature. 309: 30-33. PMID: 6325925 2. Haverstick, D.M., et al. 1985. Blood. 66: 946-952. PMID: 3876125 3. Ginsberg, M., et al. 1985. J. Biol. Chem. 260: 3931-3936. PMID: 3980461 4. Thomas, D.D., et al. 1985. J. Exp. Med. 162: 1715-1719. PMID: 3903025 5. Perlot, R.L., et al. 2002. J. Bone Miner. Res. 17: 66-76. PMID: 11771671 6. Grigoriou, V., et al. 2005. J. Biol. Chem. 280: 1733-1739. PMID: 15522882 7. Droppelmann, C.A., et al. 2009. J. Biol. Chem. 284: 13551-13561. PMID: 19276073 8. Moon, C., et al. 2009. Respir. Res. 10: 18. PMID: 19272161 If you require further help, please contact our Technical Service by phone or email or by Live Chat.
Answered by: SCBT Heidelberg Support
Date published: 2024-06-20
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Rated 5 out of 5 by from Heemskerk et alHeemskerk et al. (PubMed ID 8416943) added fibronectin inhibitor (H-Arg-Gly-Asp-Ser-OH) to a resuspension buffer used to prepare platelets for immobilization. -SCBT Publication Review
Date published: 2015-03-25
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Fibronectin Inhibitor 抑制剂 is rated 5.0 out of 5 by 1.
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