Date published: 2026-10-20

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Fatty Acid Synthase Antibody (G-11) - Western Blotting - Image 380442
脂肪酸合成酶抗体 (G-11): sc-48357. HeLa (A), Neuro-2A (B) 和 NIH/3T3 (C) 全细胞裂解液及大鼠脑组织提取物 (D) 中脂肪酸合成酶表达的 Western 印迹分析.
脂肪酸合成酶抗体 (G-11): sc-48357. HeLa (A), Neuro-2A (B) 和 NIH/3T3 (C) 全细胞裂解液及大鼠脑组织提取物 (D) 中脂肪酸合成酶表达的 Western 印迹分析.

Fatty Acid Synthase 抗体 (G-11): sc-48357

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说明书
  • Fatty Acid Synthase 抗体 G-11 是小鼠单克隆 IgG1 κ，Fatty Acid Synthase抗体, 在87篇文献中引用，规格为200 µg/ml
  • 免疫human物种的Fatty Acid Synthase的氨基酸2205-2504
  • Fatty Acid Synthase 抗体 (G-11) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 Fatty Acid Synthase
  • 抗Fatty Acid Synthase抗体（G-11）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是Fatty Acid Synthase Antibody (G-11) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与Fatty Acid Synthase Antibody (G-11) 打包提供（请参阅下面的订购信息）。
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Fatty Acid抗体

脂肪酸合成酶抗体（G-11）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、免疫组织化学和酶联免疫吸附测定（ELISA）检测小鼠、大鼠和人类来源的脂肪酸合成酶（FASN）。FASN抗体（G-11）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。FASN在脂质代谢中起着至关重要的作用，特别是在长链饱和脂肪酸的合成中，这些脂肪酸对于细胞膜的完整性和能量储存至关重要。FASN以同二聚体的形式存在，含有七个独特的催化位点，利用NADPH作为辅助因子，促进乙酰辅酶A和丙二酰辅酶A转化为脂肪酸。人类FASN基因编码的蛋白质由2504个氨基酸组成，在不同组织中的表达水平各不相同，在脑、肺和肝中的表达水平尤其高。值得注意的是，肿瘤细胞中经常出现脂肪酸合成失调的现象，其中FASN可能有助于恶性癌症中细胞的生长和存活，因此FASN成为治疗干预的潜在靶点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Fatty Acid Synthase 抗体 (G-11) 参考文献:

  1. 脂肪酸合成酶和癌变过程中的脂质生成表型。  |  Menendez, JA. and Lupu, R. 2007. Nat Rev Cancer. 7: 763-77. PMID: 17882277
  2. 脂肪酸合成酶抑制对血管生成的损害涉及 mTOR 丙二酰化。  |  Bruning, U., et al. 2018. Cell Metab. 28: 866-880.e15. PMID: 30146486
  3. 胆固醇生物合成支持小鼠和人类中缺乏脂肪酸合成酶的肝癌病变的生长。  |  Che, L., et al. 2020. Gut. 69: 177-186. PMID: 30954949
  4. 脂肪酸合成酶通过与 NS4B 相互作用参与经典猪瘟病毒的复制  |  Liu, YY., et al. 2021. J Virol. 95: e0078121. PMID: 34132567
  5. 脂肪酸合成酶：乳腺癌脑转移的可药物靶向驱动因子。  |  Menendez, JA. and Lupu, R. 2022. Expert Opin Ther Targets. 26: 427-444. PMID: 35545806
  6. 靶向脂肪酸合成酶通过铁死亡调节肝细胞癌对索拉非尼的敏感性。  |  Li, Y., et al. 2023. J Exp Clin Cancer Res. 42: 6. PMID: 36604718
  7. UCP2诱导的脂肪酸合成酶在脓毒症期间促进NLRP3炎症小体的激活。  |  Moon, JS., et al. 2023. J Clin Invest. 133: PMID: 36919700
  8. 高强度间歇训练可诱导脂肪酸合成酶的乳酰化，从而抑制脂质合成。  |  Chen, X., et al. 2023. BMC Biol. 21: 196. PMID: 37726733
  9. 脂肪酸合成酶的蛋白水解激活信号泛应激解决。  |  Wei, H., et al. 2024. Nat Metab. 6: 113-126. PMID: 38167727
  10. TRIM56通过促进脂肪酸合成酶的降解来预防非酒精性脂肪肝。  |  Xu, S., et al. 2024. J Clin Invest. 134: PMID: 38206764

订购信息

产品名称产品编号规格价格数量收藏夹

Fatty Acid Synthase 抗体 (G-11)

sc-48357
200 µg/ml
CNY2422.00

Fatty Acid Synthase (G-11): m-IgG Fc BP-HRP 套装

sc-528527
200 µg Ab; 10 µg BP
CNY2715.00

Fatty Acid Synthase (G-11): m-IgGκ BP-HRP 套装

sc-520923
200 µg Ab, 40 µg BP
CNY2715.00

Fatty Acid Synthase (G-11): m-IgG1 BP-HRP 套装

sc-542977
200 µg Ab; 20 µg BP
CNY2715.00

Fatty Acid Synthase 抗体 (G-11) AC

sc-48357 AC
500 µg/ml, 25% agarose
CNY3189.00

Fatty Acid Synthase 抗体 (G-11) HRP

sc-48357 HRP
200 µg/ml
CNY2422.00

Fatty Acid Synthase 抗体 (G-11) FITC

sc-48357 FITC
200 µg/ml
CNY2527.00

Fatty Acid Synthase 抗体 (G-11) PE

sc-48357 PE
200 µg/ml
CNY2625.00

Fatty Acid Synthase 抗体 (G-11) Alexa Fluor® 488

sc-48357 AF488
200 µg/ml
CNY2738.00

Fatty Acid Synthase 抗体 (G-11) Alexa Fluor® 546

sc-48357 AF546
200 µg/ml
CNY2738.00

Fatty Acid Synthase 抗体 (G-11) Alexa Fluor® 594

sc-48357 AF594
200 µg/ml
CNY2738.00

Fatty Acid Synthase 抗体 (G-11) Alexa Fluor® 647

sc-48357 AF647
200 µg/ml
CNY2738.00

Fatty Acid Synthase 抗体 (G-11) Alexa Fluor® 680

sc-48357 AF680
200 µg/ml
CNY2738.00

Fatty Acid Synthase 抗体 (G-11) Alexa Fluor® 790

sc-48357 AF790
200 µg/ml
CNY2738.00

Please, I want to find out whether this antibody is compatible with Guinea pigs?

Asked by: Ibrahim Yakubu
Thank you for your question. Fatty Acid Synthase (G-11) has not been validated for Guinea pig.
Answered by: BlakeJ
Date published: 2024-11-22

Can Fatty Acid Synthase (G-11): sc-48357 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: jenniferc
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Fatty Acid Synthase (G-11): sc-48357 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2018-09-18
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Rated 5 out of 5 by Morena from The bestGreat bands, super specific and strong! used in liver samples using 80ug of protein
Date published: 2026-06-02
Rated 2 out of 5 by cate from Non beneHo acquistato quest'anticorpo il mese scorso per utilizzarlo per analisi WB su lisati di cellule HCT15, HCT116 e LS513, ma non sono riuscita a visualizzare le bande durante lo sviluppo con Clarity Max Western ECL Substrate.
Date published: 2025-02-14
Rated 5 out of 5 by JuanSH from Good for WBWork fine in western blot analysis in A498 ccRCC cells
Date published: 2024-11-26
Rated 5 out of 5 by Ting from Good for western blotThis product works well in our western blot, shows clear bands with very good quality!
Date published: 2023-11-22
Rated 5 out of 5 by Loredan from Excellent results with Huh7 cell lysatesTested on Western blot on whole cell lysate (Huh7 cell line) with excellent results (excellent signal, good specificity, no background). Application: Western blot Sample: whole lysate of human hepatocytes from Huh7 cell line Gel running conditions: reduced, denaturing, 4-12% SDS-PAGE Loading amount: 30 µg protein/lane Transfer: semi-dry, on nitrocellulose membrane (0.45 µm) Blocking agent: 5% milk in TBST buffer, for 1h, RT Primary antibody dilution- 1: 400 in 5% milk, for 16 h at 4°C Secondary antibody: non- Santa Cruz antibody anti-mouse-HRP, 1:10000 dilution in 5% milk, for 1h, RT Detection: ECL substrate (femto sensitivity) Exposure time: 4 sec Bands: a strong, specific band at 260-270 kDa; non-specific bands between 130-180 kDa.
Date published: 2023-08-04
Rated 5 out of 5 by YSLiu from Excellent Fatty acid synthase antibodyThis is an outstanding antibody for detecting Fasn in livers of mice. Band is very strong, and no background at all. Single band.
Date published: 2021-06-04
Rated 5 out of 5 by Rosa from very specificThis antibody was used at 1:1000 dilution on blots loaded with 30 ug of cell protein extracts, it worked great, no extra bands.
Date published: 2021-02-25
Rated 5 out of 5 by weini from ExcellentIt is very good for western blotting in muscle and liver tissue and the dilution is 1:2000.
Date published: 2019-10-12
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Fatty Acid Synthase 抗体 (G-11) is rated 4.7 out of 5 by 36.
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