Date published: 2025-9-7

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ERp46 抗体 (F-3): sc-271465

5.0(3)
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说明书
  • ERp46抗体(F-3)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 针对human起源的ERp46内部区域内的氨基酸137-216进行
  • 推荐用于 human 来源的ERp46 WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 ERp46 抗体 (F-3) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与ERp46 抗体 (F-3) 组合成套装提供。 (请参阅下面的订购信息)。

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    関連項目

    内质网蛋白(ERps)是广泛表达的蛋白质,并定位于内质网。ERp19、ERp29、ERp46、ERp57和ERp72可能作为蛋白酶、蛋白质二硫键异构酶、硫醇-二硫化物氧化酶、磷脂酶或这些酶的组合。ERp19,也称为含硫氧还蛋白结构域蛋白12(TXNDC12),和ERp46,也称为含硫氧还蛋白结构域5(TXNDC5),属于硫氧还蛋白超家族,并含有一个具有共识活性位点序列(CxxC)的硫氧还蛋白折叠。ERp19和ERp46都是广泛表达的内质网腔蛋白质,在肝脏中最丰富,并在纯化的肝脏内质网囊泡中富集。ERp46减少胰岛素二硫键,并补充酵母中的蛋白质二硫键异构酶缺乏。ERp46可能保护缺氧细胞免于凋亡,因为其表达受缺氧诱导。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    ERp46 抗体 (F-3) 参考文献:

    1. ERp19和ERp46--内质网蛋白硫氧还蛋白家族的新成员。  |  Knoblach, B., et al. 2003. Mol Cell Proteomics. 2: 1104-19. PMID: 12930873
    2. 高血糖会降低ERp46,并调节胰腺β细胞的胰岛素含量。  |  Alberti, A., et al. 2009. Am J Physiol Endocrinol Metab. 297: E812-21. PMID: 19622788
    3. ERp46与AdipoR1结合,但不与AdipoR2结合,并调节脂联素信号。  |  Charlton, HK., et al. 2010. Biochem Biophys Res Commun. 392: 234-9. PMID: 20074551
    4. 蛋白二硫异构酶相关蛋白ERp46催化结构域的肽结合。  |  Funkner, A., et al. 2013. J Mol Biol. 425: 1340-62. PMID: 23376096
    5. 过氧化过氧化物酶 2 与蛋白二硫异构酶 ERp46 相互作用。  |  Pace, PE., et al. 2013. Biochem J. 453: 475-85. PMID: 23713588
    6. 肾细胞癌中的内质网蛋白ERp46。  |  Duivenvoorden, WC., et al. 2014. PLoS One. 9: e90389. PMID: 24594673
    7. 糖尿病条件下β细胞中ERp46的表达减少以及利拉鲁肽的作用。  |  Lampropoulou, E., et al. 2016. Metabolism. 65: 7-15. PMID: 26683792
    8. 前列腺腺癌中的内质网蛋白ERp46。  |  Duivenvoorden, WCM., et al. 2017. Oncol Lett. 13: 3624-3630. PMID: 28521463
    9. ER驻留蛋白46(ERp46)触发ER降解增强型甘露糖苷酶样蛋白3(EDEM3)的甘露糖修饰活性。  |  Yu, S., et al. 2018. J Biol Chem. 293: 10663-10674. PMID: 29784879
    10. 内质网蛋白46(ERp46)在小鼠血小板功能和动脉血栓形成中的新作用。  |  Zhou, J., et al. 2022. Blood. 139: 2050-2065. PMID: 34752599

    订购信息

    产品名称产品编号规格价格数量收藏夹

    ERp46 抗体 (F-3)

    sc-271465
    200 µg/ml
    RMB2377.00

    ERp46 (F-3): m-IgG Fc BP-HRP 套装

    sc-537641
    200 µg Ab; 10 µg BP
    RMB2662.00

    ERp46 (F-3): m-IgGκ BP-HRP 套装

    sc-534972
    200 µg Ab; 40 µg BP
    RMB2662.00

    ERp46 (F-3): m-IgG1 BP-HRP 套装

    sc-545277
    200 µg Ab; 20 µg BP
    RMB2662.00

    Can ERp46 (F-3): sc-271465 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

    Asked by: jerojero
    Thank you for your question. Yes, ERp46 (F-3): sc-271465 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
    Answered by: Technical Support
    Date published: 2017-02-25
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    Rated 5 out of 5 by from Strong band seen in WB in HeLa whole cell lysateStrong band seen in WB in HeLa whole cell lysate. -SCBT QC
    Date published: 2015-06-03
    Rated 5 out of 5 by from Strong band detected in WB in 293T wholeStrong band detected in WB in 293T whole cell lysate. -SCBT QC
    Date published: 2015-02-28
    Rated 5 out of 5 by from Produced excellent immunoperoxidase cytoplasmicProduced excellent immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human thyroid gland tissue. -SCBT QC
    Date published: 2015-02-09
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    ERp46 抗体 (F-3) is rated 5.0 out of 5 by 3.
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