EPZ6438 的分子结构, CAS编号: 1403254-99-8
EPZ6438 (CAS 1403254-99-8)
备用名:
N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4′-(4-morpholinylmethyl)-[1,1′-biphenyl]-3-carboxamide; Tazemetostat
CAS号码:
1403254-99-8
分子量:
572.7
分子式:
C34H44N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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EPZ6438 (CAS 1403254-99-8) 参考文献
- 发现IHMT-337是一种针对CDK4转录的强效不可逆EZH2抑制剂,可用于治疗恶性肿瘤。 | Mei, H., et al. 2023. Signal Transduct Target Ther. 8: 18. PMID: 36642705
- UHRF1/UBE2L6/UBR4介导的泛素化调节EZH2的丰度,从而调节黑色素瘤中的黑素细胞分化表型。 | Kuser-Abali, G., et al. 2023. Oncogene. 42: 1360-1373. PMID: 36906655
- EZH2活性的调节可诱导间变性甲状腺癌的抗肿瘤效应和细胞再分化。 | de Mello, DC., et al. 2023. Int J Mol Sci. 24: PMID: 37175580
- SAM-竞争性 EZH2 抑制剂通过 EZH2 依赖性诱导 ABC 转运体诱导铂金抗性 | Groß, E., et al. 2023. Cancers (Basel). 15: PMID: 37297005
- 人类EZH2的药剂抑制会影响再生β样细胞的能力,并影响胰腺导管细胞中的体外胰岛素释放。 | Naina Marikar, S., et al. 2023. Clin Epigenetics. 15: 101. PMID: 37309004
- 基于EZH2的PROTAC的设计, 合成和评估,靶向淋巴瘤中的PRC2复合物。 | Xie, H., et al. 2023. Bioorg Chem. 140: 106762. PMID: 37572533
- 细胞衰老通过Notch-EZH2启动肝纤维化消退。 | Song, P., et al. 2023. MedComm (2020). 4: e346. PMID: 37614965
- EZH2蛋白稳定性的调节:新机制, 在肿瘤发生中的作用以及临床应用。 | Guo, Y., et al. 2024. EBioMedicine. 100: 104972. PMID: 38244292
- EZH2抑制可重新激活表观遗传学沉默的FMR1,并使脆性X综合征神经元的分子和电生理异常恢复正常。 | Fang, M., et al. 2024. Front Neurosci. 18: 1348478. PMID: 38449737
- 抑制EZH2可减少小鼠胃间质细胞衰老相关衰退。 | Taheri, N., et al. 2024. Cell Mol Gastroenterol Hepatol. 101376. PMID: 38969206
抑制剂：
4930557A04Rik, AEBP2, AHDC1, ANKRD24, ASF1A, AU022751, BAF57, BPTF, BRWD3, CARM1, CHD (chromodomain helicase), CHD5, CHD7, CHD9, CRBP IV, DLD, DOT1L1, DPY-30, DUX3, E130012A19Rik, E430029J22Rik, EG385328, EG434797, ENX-2, EPC2, Evi-1, EZHIP, FAM136A, FOXF2, Histone cluster 1 H2AA, Histone cluster 1 H2AB, Histone cluster 1 H2AC, Histone cluster 1 H2AE, Histone cluster 1 H2AH, Histone cluster 1 H2AI, Histone cluster 1 H2AJ, Histone cluster 1 H2AK, Histone cluster 1 H2AL, Histone cluster 1 H2AM, Histone cluster 1 H2BA, Histone cluster 1 H2BB, Histone cluster 1 H2BC, Histone cluster 1 H2BE, Histone cluster 1 H2BF, Histone cluster 1 H2BG, Histone cluster 1 H2BH, Histone cluster 1 H2BI, Histone cluster 1 H2BJ, Histone cluster 1 H2BL, Histone cluster 1 H2BM, Histone cluster 1 H2BO, Histone cluster 1 H3A, Histone cluster 1 H3C, Histone cluster 1 H3D, Histone cluster 1 H3F, Histone cluster 1 H4G, Histone H2B, Histone H2BM, hIws1, HP1γ, kismet, L3MBTL, L3MBTL2, LMCD1, LMO1, LOC340094, LOC642892, Lyl-1, MBTD1, Mel-18, Menin, Mettl7a2-Higd1c, Mi2-β, MSL-1, MSL3L2, NSD3, Obox3, Olfr547, Olr1128, Olr1217, Olr561, Olr694, Paf1, PCGF5, Peg10, PHC1, PHC2, PHC3, PHF1, PHF19, PHF20, PHF20L1, PHF21A, PHF21B, Plectin, PRDM12, PRDM16, PRHOXNB, RCOR2, RG9MTD1, Rslcan-13, SCML2, SFMBT2, Six1, SMYD4, Snf2, SUV420H1, Trav12d-3, TRIM2, Trimethyl Histone H3, Trimethyl Histone H4, TSHZ1, TSPYL4, UTX, VPS72, ZFP605, ZNF165, ZNF236, ZNF267, ZNF274, ZNF397, ZNF536, ZNF709, ZNF71, ZNF740, ZNF806, ZNF81, ZNF853, ZSCAN1, 和 ZSCAN4D.激活剂：
1700011H14Rik, ACBP, ALG5, ASXL2, ASXL3, BAF53B, BAZ2B, BRD9, DDB1, Dnmt3a, DPF1, E430018J23Rik, EG236663, EZHIP, H3-K9-HMTase, Histone cluster 1 H2AN, Histone cluster 1 H2BH, Histone cluster 1 H4J, HP1, L3MBTL3, Lamin A, LEUTX, LRRC4B, MAGE-A4, MAGE-A6, MLLT6, MPc3_CBX8, MSL3L1, NSD1, PCGF6, PHF8, R-Spondin, RIOK2, Set2, SETBP1, SNAPC 45, TRAP100, TSPYL6, ZBTB38, ZFYVE28, 和 ZNF408.订购信息
| 产品名称 | 产品编号 | 规格 | 价格 | 数量 | 收藏夹 | |
EPZ6438, 1 mg | sc-507456 | 1 mg | RMB745.00 |