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Ep-CAM Antibody (9C4) - Immunohistochemistry - Image 7967
Ep-CAM 抗体 (9C4): sc-21792. 福尔马林固定, 石蜡包埋的人正常结肠组织的免疫过氧化物酶染色, 显示膜定位.
Ep-CAM Antibody (9C4) - Immunohistochemistry - Image 7967
Ep-CAM 抗体 (9C4): sc-21792. 福尔马林固定, 石蜡包埋的人正常结肠组织的免疫过氧化物酶染色, 显示膜定位.
Ep-CAM Antibody (9C4) - Immunofluorescence - Image 7966
Ep-CAM 抗体 (9C4): sc-21792. 甲醇固定的 SW480 细胞免疫荧光染色, 显示膜定位.
Ep-CAM Antibody (9C4) - Flow Cytometry - Image 11480
Ep-CAM 抗体 (9C4) PE: sc-21792 PE. SW480 细胞的 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG2b, sc-2868.
Ep-CAM 抗体 (9C4): sc-21792. 福尔马林固定, 石蜡包埋的人正常结肠组织的免疫过氧化物酶染色, 显示膜定位.

Ep-CAM 抗体 (9C4): sc-21792

4.3(3)
寫評論提問
说明书
  • Ep-CAM抗体(9C4)是小鼠单克隆IgG2b κ, 在8篇文献中引用，规格为200 µg/ml
  • 针对DU4475乳腺癌细胞系
  • Ep-CAM 抗体 (9C4) 推荐用于IF, IHC(P) 和 FCM，检测human 来源的 Ep-CAM
  • 抗Ep-CAM抗体（9C4）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • m-IgG Fc BP-HRP是Ep-CAM Antibody (9C4) 适用于 IHC(P) 应用。 的首选辅助检测试剂。该试剂现与Ep-CAM Antibody (9C4) 搭配使用（请参阅下面的订购信息）。
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描述
基因信息
说明书与实验方案
研究信息

関連項目

Ep-CAM抗体（9C4）是一种小鼠单克隆IgG2b kappa轻链抗体，可通过免疫荧光（IF）、石蜡包埋切片免疫组织化学（IHCP）和流式细胞术（FCM）检测人类来源的Ep-CAM。抗Ep-CAM抗体（9C4）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物，可满足不同实验需求。上皮细胞粘附分子，也称为肿瘤相关钙信号转导蛋白1和MK-1，在细胞粘附中起着至关重要的作用，主要表达于正常人体上皮组织以及各种癌组织中。人类Ep-CAM基因编码一种314个氨基酸的蛋白质，该蛋白质有两种形式，其中主要形式更为常见；有趣的是，这些形式的表达可以通过氨基糖苷化抑制剂Tunicamycin来改变。值得注意的是，Ep-CAM在多种癌症中通常会过度表达，因此Ep-CAM成为人类实体肿瘤可视化与治疗策略的重要靶点。该蛋白具有一个细胞外结构域，其中包括两个表皮生长因子样重复结构，它们对于粘附特性至关重要，从而凸显了Ep-CAM在维持组织结构和完整性方面的重要性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Ep-CAM 抗体 (9C4) 参考文献:

  1. 上皮细胞粘附分子（Ep-CAM）作为一种形态调节分子，是外科病理学的一种工具。  |  Winter, MJ., et al. 2003. Am J Pathol. 163: 2139-48. PMID: 14633587
  2. 唾液腺肿瘤中上皮细胞粘附分子的差异表达。  |  Phattarataratip, E., et al. 2016. Ann Diagn Pathol. 24: 62-7. PMID: 27649957
  3. 上皮细胞粘附分子N-糖基化对乳腺癌细胞凋亡的作用。  |  Zhang, D., et al. 2017. Tumour Biol. 39: 1010428317695973. PMID: 28349835
  4. 上皮细胞粘附分子（EpCAM）过度表达与胃癌患者之间的关系：系统回顾和荟萃分析。  |  Dai, M., et al. 2017. PLoS One. 12: e0175357. PMID: 28403178
  5. 先天性簇状肠病患者的纯合错义上皮细胞粘附分子变异及文献综述。  |  Güvenoğlu, M., et al. 2022. Pediatr Gastroenterol Hepatol Nutr. 25: 441-452. PMID: 36451688
  6. 上皮细胞粘附分子（EpCAM）调节 HGFR 信号传导，促进结肠癌进展和转移。  |  Lee, CC., et al. 2023. J Transl Med. 21: 530. PMID: 37543570
  7. 口腔鳞状细胞癌中的结外扩展和上皮细胞粘附分子过度表达。  |  Fukushima, H., et al. 2023. Anticancer Res. 43: 5155-5166. PMID: 37909986
  8. β-羟基异戊酰石蒜碱通过抑制dUTP焦磷酸酶的表达根除上皮细胞粘附分子阳性的肝癌干细胞。  |  Asahina, Y., et al. 2023. Int J Mol Sci. 24: PMID: 38003473
  9. 针对胃癌上皮细胞粘附分子的嵌合抗原受体T细胞疗法：肿瘤耐药机制。  |  Yang, Y., et al. 2023. Cancers (Basel). 15: PMID: 38067255
  10. 上皮细胞粘附分子的细胞内结构域诱导Wnt受体转录，促进结肠直肠癌的发展。  |  Panda, SS., et al. 2024. J Biomed Sci. 31: 72. PMID: 39010070

订购信息

产品名称产品编号规格价格数量收藏夹

Ep-CAM 抗体 (9C4)

sc-21792
200 µg/ml
CNY2422.00

Ep-CAM (9C4): m-IgG Fc BP-HRP 套装

sc-525507
200 µg Ab; 10 µg BP
CNY2715.00

Ep-CAM 抗体 (9C4) AC

sc-21792 AC
500 µg/ml, 25% agarose
CNY3189.00

Ep-CAM 抗体 (9C4) HRP

sc-21792 HRP
200 µg/ml
CNY2422.00

Ep-CAM 抗体 (9C4) FITC

sc-21792 FITC
200 µg/ml
CNY2527.00

Ep-CAM 抗体 (9C4) PE

sc-21792 PE
200 µg/ml
CNY2625.00

Ep-CAM 抗体 (9C4) Alexa Fluor® 488

sc-21792 AF488
200 µg/ml
CNY2738.00

Ep-CAM 抗体 (9C4) Alexa Fluor® 546

sc-21792 AF546
200 µg/ml
CNY2738.00

Ep-CAM 抗体 (9C4) Alexa Fluor® 594

sc-21792 AF594
200 µg/ml
CNY2738.00

Ep-CAM 抗体 (9C4) Alexa Fluor® 647

sc-21792 AF647
200 µg/ml
CNY2738.00

Ep-CAM 抗体 (9C4) Alexa Fluor® 680

sc-21792 AF680
200 µg/ml
CNY2738.00

Ep-CAM 抗体 (9C4) Alexa Fluor® 790

sc-21792 AF790
200 µg/ml
CNY2738.00

if i want to read the concentration of ep cam antiobodies using microplater reader or spectrofotormeter in which lamda i can read it accurately. Thankyou

Asked by: Arif1996
Thank you for your question. We recommend detecting the antibodies at a wavelength (lambda) of 280 nm.
Answered by: Technical Support
Date published: 2017-05-30

Can Ep-CAM (9C4): sc-21792 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Trav11
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Ep-CAM (9C4): sc-21792 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24

I am planning to use 9C4 EpCAM antibody to stain human cells in mouse tissues. Have you tested the reactivity against mouse EpCAM? Another question is which part of the protein does the antibody recognize? Extracellular or intracellular? Thank you.

Asked by: yasemin
Thank you for your question. Unfortunately we do not recommend nor warranty this antibody for use on mouse samples as we do not have any record of mouse reactivity. The antibody was made against a DU.4475 breast carcinoma and the exact epitope has not been mapped. It is a surface antigen, so extracellular/membrane expression is expected. Please contact Technical Service by phone, (800)-457-3801 option 2, email <[email protected]>, or by live chat directly on our website, www.scbt.com.
Answered by: Tech Service
Date published: 2016-10-12
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Rated 5 out of 5 by cousins from beautiful figureThe target protein is the full-length recombinant Human-EPCAM protein with GST tag.
Date published: 2017-02-16
Rated 4 out of 5 by LF from Produced robust immunoperoxidase membraneProduced robust immunoperoxidase membrane staining in formalin fixed, paraffin-embedded human normal colon tissue. -SCBT QC
Date published: 2015-03-07
Rated 4 out of 5 by HC from Produced wonderful FCM data for SW480 cellsProduced wonderful FCM data for SW480 cells. -SCBT QC
Date published: 2013-04-26
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Ep-CAM 抗体 (9C4) is rated 4.3 out of 5 by 3.
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