Date published: 2026-10-24

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Endoglin/CD105 Antibody (P4A4) - Western Blotting - Image 6881
Endoglin 抗体 (P4A4): sc-20072. 人重组 Endoglin 的 Western 印迹分析.
Endoglin 抗体 (P4A4): sc-20072. 人重组 Endoglin 的 Western 印迹分析.

Endoglin/CD105 抗体 (P4A4): sc-20072

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说明书
  • Endoglin/CD105抗体(P4A4)是小鼠单克隆IgG2b κ, 在14篇文献中引用，规格为200 µg/ml
  • 免疫human物种的Endoglin
  • 抗-Endoglin/CD105 抗体 (P4A4) 推荐用于 WB, IP 和 IF，检测mouse, rat 和human 来源的 Endoglin dimer under non-reducing conditions, and Endoglin monomer under reducing conditions
  • 抗Endoglin/CD105抗体（P4A4）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 还提供无叠氮化物激活T细胞与内皮结合，sc-20072 L，200 µg/0.1 ml
  • 2b BP-HRP">m-IgG2b BP-HRP和m-IgGκ BP-HRP是Endoglin/CD105 Antibody (P4A4) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Endoglin/CD105 Antibody (P4A4) 打包提供（请参阅下面的订购信息）。
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関連項目

内皮素抗体（P4A4）是一种小鼠单克隆IgG2b kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）和免疫荧光（IF）等方法检测小鼠、大鼠和人类样本中的内皮素。抗内皮素抗体（P4A4）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。内皮素（Endoglin）又称CD105，在血管生成中起着至关重要的作用，是转化生长因子-β（TGF-β）信号的共受体，而TGF-β信号对于血管发育和修复至关重要。内皮素主要位于血管内皮细胞表面，它促进TGF-β配体与其各自受体结合，从而影响细胞反应，调节血管的形成和稳定性。内皮细胞黏蛋白的突变与遗传性出血性毛细血管扩张症（HHT）有关，这是一种遗传性疾病，其特征是血管形成异常，导致出血过多和血管畸形等症状。了解内皮细胞黏蛋白的功能和位置对于阐明其在血管生物学和血管功能障碍相关疾病发病机理中的作用至关重要。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Endoglin/CD105 抗体 (P4A4) 参考文献:

  1. 血管细胞生理学中内皮素的新生化途径。  |  Bernabeu, C., et al. 2007. J Cell Biochem. 102: 1375-88. PMID: 17975795
  2. 内皮素介导的血管重塑：遗传性出血性毛细血管扩张的机制。  |  Lebrin, F. and Mummery, CL. 2008. Trends Cardiovasc Med. 18: 25-32. PMID: 18206806
  3. 内皮素用于肿瘤成像和靶向癌症治疗。  |  Paauwe, M., et al. 2013. Expert Opin Ther Targets. 17: 421-35. PMID: 23327677
  4. 内皮素在HIV相关先兆子痫胎盘中的作用。  |  Govender, N., et al. 2015. Hypertens Pregnancy. 34: 342-54. PMID: 26153627
  5. 内皮素与VEGFR2相互作用，促进血管生成。  |  Tian, H., et al. 2018. FASEB J. 32: 2934-2949. PMID: 29401587
  6. TGF-β家族膜结合辅助受体β-葡聚糖和内皮素的结构生物学。  |  Kim, SK., et al. 2019. Exp Biol Med (Maywood). 244: 1547-1558. PMID: 31601110
  7. 膜和可溶性内皮素在代谢综合征相关的心血管和代谢紊乱中的作用。  |  Vicen, M., et al. 2021. Cell Mol Life Sci. 78: 2405-2418. PMID: 33185696
  8. 基于 Endoglin/CD105 的癌症和心血管疾病成像： 系统综述  |  Sier, VQ., et al. 2021. Int J Mol Sci. 22: PMID: 33946583
  9. 内皮素水平与冠状动脉粥样硬化呈负相关。  |  Chen, H., et al. 2021. Lipids Health Dis. 20: 127. PMID: 34602076
  10. 内皮素通过调节TGF-β/ALK/Smads信号的激活加重腹膜纤维化。  |  Huang, Q., et al. 2022. Front Pharmacol. 13: 973182. PMID: 36210850

订购信息

产品名称产品编号规格价格数量收藏夹

Endoglin/CD105 抗体 (P4A4)

sc-20072
200 µg/ml
CNY2422.00

Endoglin/CD105 (P4A4): m-IgGκ BP-HRP 套装

sc-520719
200 µg Ab, 40 µg BP
CNY2715.00

Endoglin/CD105 (P4A4): m-IgG2b BP-HRP 套装

sc-548848
200 µg Ab; 10 µg BP
CNY2715.00

Endoglin/CD105 抗体 (P4A4) L

sc-20072 L
200 µg/0.1 ml
CNY2422.00

Endoglin/CD105 抗体 (P4A4) AC

sc-20072 AC
500 µg/ml, 25% agarose
CNY3189.00

Endoglin/CD105 抗体 (P4A4) HRP

sc-20072 HRP
200 µg/ml
CNY2422.00

Endoglin/CD105 抗体 (P4A4) FITC

sc-20072 FITC
200 µg/ml
CNY2527.00

Endoglin/CD105 抗体 (P4A4) PE

sc-20072 PE
200 µg/ml
CNY2625.00

Endoglin/CD105 抗体 (P4A4) Alexa Fluor® 488

sc-20072 AF488
200 µg/ml
CNY2738.00

Endoglin/CD105 抗体 (P4A4) Alexa Fluor® 546

sc-20072 AF546
200 µg/ml
CNY2738.00

Endoglin/CD105 抗体 (P4A4) Alexa Fluor® 594

sc-20072 AF594
200 µg/ml
CNY2738.00

Endoglin/CD105 抗体 (P4A4) Alexa Fluor® 647

sc-20072 AF647
200 µg/ml
CNY2738.00

Endoglin/CD105 抗体 (P4A4) Alexa Fluor® 680

sc-20072 AF680
200 µg/ml
CNY2738.00

Endoglin/CD105 抗体 (P4A4) Alexa Fluor® 790

sc-20072 AF790
200 µg/ml
CNY2738.00

マウス腎のIHC.WBに使用できますか？またどの種類のものを買えばよいですか？

Asked by: kurose
Thank you for your question, this antibody is recommended for WB and immunostaining experiments on cells, frozen sections. Immunostaining of paraffin sections is not warranted. Thank you. ご質問ありがとうございます。この抗体は、細胞、凍結切片のWBおよび免疫染色実験に推奨されます。パラフィン切片の免疫染色は推奨されません。ありがとうございました。
Answered by: Jiajun Z
Date published: 2025-08-07

hello, do you guys have a CD105 antibody specific to canine?

Asked by: Orzala
Thank you for your question. This antibody has not yet been tested in canine and so that is not a recommended species at this time. We are still gathering data to show on our website. Feel free to reach out to Technical Service for further assistance
Answered by: Tech Service 1
Date published: 2021-02-04

I bought the L form of this antibody, sc-20072 L for blocking (neutralization). How long can I store this at in the refridgerator?

Asked by: Germaine
The L form of the antibody should be stored at -20°C. Once thawed, we recommend using as soon as possible, although it is usually stable for up to 2 weeks at 4 degrees.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 2 out of 5 by dkch from Not good in WB, ok by FCM.The antibody was tried to validate a modulation found on lung cancer cells by a Proteome array. In western blot it gave a dirty pattern, with no clear specific band, while by flow cytometry it gave a strong signal.
Date published: 2023-02-02
Rated 5 out of 5 by RK32 from IHC-P Immunofluorescence - Works GreatTested sample of this antibody for CD105 on IHC-P vascular tissue section following TE Buffer (pH 9.0) antigen retrieval (20 min, 95C). Staining was very specific with little background. Used anti-mouseAF488 secondary antibody at 1:500. Highly recommend this antibody for IHC-P immunofluorescence for Endoglin (CD105).
Date published: 2018-01-15
Rated 5 out of 5 by odelette from Apelin抗体我去年购买的此抗体SC-33804，内皮细胞WB结果显示该抗体特异性非常好，条带单一，大小在17KDa左右。
Date published: 2017-07-11
Rated 5 out of 5 by LR from Antibody was diluted 1:1000 in PBSAntibody was diluted 1:1000 in PBS
Date published: 2015-10-16
Rated 5 out of 5 by HF from IHC with paraffin embedded human cancer tissueIHC with paraffin embedded human cancer tissue specimens. -SCBT Publication Review
Date published: 2015-06-24
Rated 5 out of 5 by TO from Performed western blot with rat HSCs (hepaticPerformed western blot with rat HSCs (hepatic stellate cells). -SCBT QC
Date published: 2015-05-27
Rated 5 out of 5 by MS from Produced superb immunofluorescence membraneProduced superb immunofluorescence membrane staining in methanol-fixed HUV-EC-C cells. -SCBT QC
Date published: 2015-02-03
Rated 5 out of 5 by NZ from Strong band in western blot using human recombinantStrong band in western blot using human recombinant Endoglin. -SCBT QC
Date published: 2015-01-20
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Endoglin/CD105 抗体 (P4A4) is rated 4.7 out of 5 by 9.
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