Date published: 2025-9-8

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EMBP 抗体 (F-2): sc-365702

5.0(2)
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说明书
  • EMBP抗体(F-2)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 免疫human物种的代表全长EMBP的氨基酸1-222
  • 推荐用于 human 来源的EMBP WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 EMBP 抗体 (F-2) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与EMBP 抗体 (F-2) 组合成套装提供。 (请参阅下面的订购信息)。

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    関連項目

    嗜酸性粒细胞主要碱性蛋白(EMBP),也称为MBP、PRG2、蛋白聚糖2、BMPG或骨髓自然杀伤细胞活化剂,是嗜酸性粒细胞颗粒结晶核心的组成部分。胎盘和妊娠血清中存在高水平的pro-EMBP,它与其他几种蛋白质(包括妊娠相关血浆蛋白A(PAPPA)、血管紧张素原(AGT)和C3dg)形成复合物。 EMBP可能作为细胞毒素和蠕虫毒素影响抗寄生虫防御机制,并可能在免疫超敏反应中发挥作用。 EMBP刺激I类(A)磷酸肌醇3激酶的Src激酶依赖性激活,进而激活中性粒细胞中的蛋白激酶Cζ。 EMBP转录受GATA-1、PU.1和C/EBPε同工型的新组合相互作用调节。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    EMBP 抗体 (F-2) 参考文献:

    1. 鉴定一种新的小鼠嗜酸性粒细胞主要碱性蛋白(mMBP)基因:mMBP-2 的克隆和特征。  |  Macias, MP., et al. 2000. J Leukoc Biol. 67: 567-76. PMID: 10770291
    2. 妊娠相关血浆蛋白-A 和嗜酸性粒细胞主要碱性蛋白原形的复合物。二硫结构和碳水化合物附着。  |  Overgaard, MT., et al. 2003. J Biol Chem. 278: 2106-17. PMID: 12421832
    3. 嗜酸性粒细胞主要碱性蛋白通过IA类磷酸肌醇3-激酶和蛋白激酶C-zeta依赖途径刺激中性粒细胞产生超氧化物。  |  Shenoy, NG., et al. 2003. J Immunol. 171: 3734-41. PMID: 14500673
    4. 免疫反应性嗜酸性粒细胞主要碱性蛋白与胎盘隔膜和囊肿的关系。  |  Wasmoen, TL., et al. 1991. Am J Obstet Gynecol. 165: 416-20. PMID: 1872350
    5. 人嗜酸性粒细胞主要碱性蛋白可诱导灵长类动物气道收缩和气道高反应性。  |  Gundel, RH., et al. 1991. J Clin Invest. 87: 1470-3. PMID: 2010556
    6. 人体病理组织中嗜酸性粒细胞主要碱性蛋白在曼氏血吸虫虫卵上的定位。  |  Kephart, GM., et al. 1988. Am J Pathol. 133: 389-96. PMID: 2461091
    7. 嗜酸性粒细胞主要碱性蛋白可增强清醒小鼠对吸入性刺激物的咳嗽反应。  |  Lin, AH., et al. 2019. Am J Physiol Regul Integr Comp Physiol. 317: R93-R97. PMID: 30995073
    8. 妊娠晚期血浆嗜酸性粒细胞主要碱性蛋白水平的升高可预测分娩的开始。  |  Wasmoen, TL., et al. 1987. Proc Natl Acad Sci U S A. 84: 3029-32. PMID: 3472249
    9. 人嗜酸性粒细胞主要碱性蛋白-1 的原位结晶结构。  |  Yang, JE., et al. 2024. bioRxiv.. PMID: 39416224
    10. 小麦碱性亮氨酸拉链蛋白 EmBP-1 与核糖体结合位点的结合受核糖体定位的调节。  |  Niu, X., et al. 1996. Plant Cell. 8: 1569-87. PMID: 8837510

    订购信息

    产品名称产品编号规格价格数量收藏夹

    EMBP 抗体 (F-2)

    sc-365702
    200 µg/ml
    RMB2377.00

    EMBP (F-2): m-IgG Fc BP-HRP 套装

    sc-537825
    200 µg Ab; 10 µg BP
    RMB2662.00

    EMBP (F-2): m-IgGκ BP-HRP 套装

    sc-535240
    200 µg Ab; 40 µg BP
    RMB2662.00

    EMBP (F-2): m-IgG1 BP-HRP 套装

    sc-545380
    200 µg Ab; 20 µg BP
    RMB2662.00

    Hi, Is this antibody conjugated? I can't find this on the datasheet. Thanks!

    Asked by: YashC
    Thank you for your question. Unfortunately we do not offer this antibody conjugated as a standard product. If you are interested in getting it conjugated as a special order, please reach out to our Special orders team by calling our Technical Service Department, or email <[email protected]>.
    Answered by: Tech Service
    Date published: 2019-12-09

    Can EMBP (F-2): sc-365702 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

    Asked by: TinTin
    Thank you for your question. Yes, EMBP (F-2): sc-365702 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
    Answered by: Technical Support
    Date published: 2017-02-28
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    Rated 5 out of 5 by from Excellent immunoperoxidase cytoplasmic stainingExcellent immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human placenta tissue. -SCBT QC
    Date published: 2015-01-03
    Rated 5 out of 5 by from Nice Western Blot data of EMBP expression in nonNice Western Blot data of EMBP expression in non-transfected and human EMBP transfected CMV whole cell lysates. -SCBT QC
    Date published: 2014-06-11
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    EMBP 抗体 (F-2) is rated 5.0 out of 5 by 2.
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