Date published: 2025-9-8

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eIF6 抗体 (A-12): sc-390441

5.0(4)
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说明书
  • eIF6抗体(A-12)是小鼠单克隆mouse IgG1 κ κ, 在3篇文献中引用,规格为200 µg/ml
  • 免疫human物种的代表全长eIF6的氨基酸1-245
  • 推荐用于 mouse, rat 和 human 来源的eIF6 WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 eIF6 抗体 (A-12) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与eIF6 抗体 (A-12) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

真核细胞中蛋白质合成的起始是由蛋白质起始因子和RNA分子之间的相互作用来调节的。真核起始因子(eIFs)被用于一系列反应中,这些反应导致80S核糖体组装,并最终导致翻译。eIF6(真核翻译起始因子6)也被称为CAB、B2GCN同源物、p27(BBP)或B4整合素相互作用物,是一种由245个氨基酸组成的蛋白质,定位于细胞质以及细胞核内的核仁。eIF6的N端和C端亚结构域被认为含有重要的核仁定位序列。eIF6可能是核糖体功能和生成的调节器。eIF6的功能是结合并将60S核糖体亚基从细胞核转移到细胞质,有效地阻止60S亚基与40S亚基结合,并抑制80S起始复合物的形成。80S核糖体的形成调控也调节转录。一旦转移到细胞质中,eIF6-60S核糖体亚基复合物就会通过RACK1/PKC途径进行磷酸化,这一事件导致eIF6从60S亚基上解离。eIF6的上调与多种癌症密切相关,如卵巢癌,这表明eIF6可能参与致癌过程。

仅限研究使用。不适用于诊断和治疗用途。

订购信息

产品名称产品编号规格价格数量收藏夹

eIF6 抗体 (A-12)

sc-390441
200 µg/ml
RMB2377.00

eIF6 (A-12): m-IgG Fc BP-HRP 套装

sc-540802
200 µg Ab; 10 µg BP
RMB2662.00

eIF6 (A-12): m-IgG1 BP-HRP 套装

sc-542377
200 µg Ab; 20 µg BP
RMB2662.00

Can eIF6 (A-12): sc-390441 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Randy McDonald
Thank you for your question. Yes, eIF6 (A-12): sc-390441 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-25
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Rated 5 out of 5 by from Works wellUsed for immunoprecipitation and westerns-works very well.
Date published: 2021-10-07
Rated 5 out of 5 by from Excellent results in IHC(P) with human colonExcellent results in IHC(P) with human colon samples -SCBT QC
Date published: 2015-04-23
Rated 5 out of 5 by from Strong bands with no background seen in WesternStrong bands with no background seen in Western Blot with K-562, RKO, Ramos, HEK293, MIA PaCa-2 and HeLa whole cell lysates -SCBT QC
Date published: 2015-04-02
Rated 5 out of 5 by from Brilliant IF results with PFA fixed HepG2 cellsBrilliant IF results with PFA fixed HepG2 cells, saw nucleolar and nuclear localization -SCBT QC
Date published: 2013-03-04
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eIF6 抗体 (A-12) is rated 5.0 out of 5 by 4.
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