Date published: 2025-9-8
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eIF4AII Antibody (G-5) - Western Blotting - Image 358702
eIF4AII 抗体 (G-5): sc-137147. NCI-H292 (A), SK-N-MC (B), F9 (C), C3H/10T1/2 (D), NRK (E) 和 L8 (F) 全细胞裂解液中 eIF4AII 表达的 Western 印迹分析.
eIF4AII 抗体 (G-5): sc-137147. NCI-H292 (A), SK-N-MC (B), F9 (C), C3H/10T1/2 (D), NRK (E) 和 L8 (F) 全细胞裂解液中 eIF4AII 表达的 Western 印迹分析.

eIF4AII 抗体 (G-5): sc-137147

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寫評論提問

说明书
  • eIF4AII抗体(G-5)是小鼠单克隆IgG2b κ, 在5篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的eIF4AII的N-terminus的氨基酸2-43之间
  • 推荐用于 mouse, rat 和 human 来源的eIF4AII WB, IP, IF 和 ELISA检测; 也和以下物种反应，包括： 和 equine, canine, bovine and porcine
  • m-IgG Fc BP-HRP和 2b BP-HRP">m-IgG2b BP-HRP是eIF4AII Antibody (G-5) 适用于 WB 应用。 的首选辅助检测试剂，这些试剂现与eIF4AII Antibody (G-5) 打包提供（请参阅下面的订购信息）。

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描述
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说明书与实验方案
研究信息

関連項目

额外eIF抗体，包括eIF1, eIF1AY, eIF2 α, eIF2B α, eIF2B β, eIF2B δ, eIF2B ε, eIF2 β, eIF2B γ, eIF2C, eIF2C2, eIF2C4, eIF2D, eIF3 p110, eIF3 α和eIF3 β

真核生物的翻译起始需要组装一个80S核糖体复合物。真核起始因子(eIFs)在一系列反应中被利用，这些反应导致80S核糖体的组装和翻译的起始。哺乳动物真核翻译起始因子4F (eIF4F)是一种含有eIF4A、eIF4E和eIF4G的蛋白质复合物，它在5′-帽基序处结合mRNA，并将43S核糖体前起始复合物招募到符合条件的转录本上。与eIF4B一起，eIF4F复合物介导mRNA二级结构的解旋，以促进核糖体的结合。eIF4E特异性与5′帽相互作用，eIF4A(I，II)是双向RNA解旋酶，eIF4G(I，II)是支架蛋白，协调eIF4E、eIF4A、eIF3和40S核糖体。人类eIF4AI (eIF4A，DDX2A)是一种含有406个氨基酸的蛋白质，与小鼠eIF4AI的同源性为92.7%。人类eIF4A1的启动子区域包含TATA和CAAT基序以及Sp1和AP2的共识结合位点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

eIF4AII 抗体 (G-5) 参考文献:

  1. 真核翻译起始因子 4AIII（eIF4AIII）在功能上有别于 eIF4AI 和 eIF4AII。  |  Li, Q., et al. 1999. Mol Cell Biol. 19: 7336-46. PMID: 10523622
  2. 一种将eIF4AI活性与eIF4AII转录物联系起来的细胞反应。  |  Galicia-Vázquez, G., et al. 2012. RNA. 18: 1373-84. PMID: 22589333
  3. 非小细胞肺癌中EIF4A2的下调与预后不良有关。  |  Shaoyan, X., et al. 2013. Clin Lung Cancer. 14: 658-65. PMID: 23867391
  4. 人类中，microRNA可触发eIF4AI和eIF4AII与目标mRNA的分离。  |  Fukao, A., et al. 2014. Mol Cell. 56: 79-89. PMID: 25280105
  5. eIF4A2 的 Sumoylation 会影响应激颗粒的形成。  |  Jongjitwimol, J., et al. 2016. J Cell Sci. 129: 2407-15. PMID: 27160682
  6. eIF4A2是HIV-1高效复制所需的一种宿主因子。  |  Ndzinu, JK., et al. 2018. Microbes Infect. 20: 346-352. PMID: 29842983
  7. DEAD-box解旋酶eIF4A2抑制CNOT7脱腺苷酸化活性。  |  Meijer, HA., et al. 2019. Nucleic Acids Res. 47: 8224-8238. PMID: 31180491
  8. eIF4A2的高表达与食管鳞状细胞癌的预后不良有关。  |  Lyu, S., et al. 2020. Oncol Lett. 20: 177. PMID: 32934744
  9. 罕见的EIF4A2变异与以智力障碍、肌张力低下和癫痫为特征的神经发育障碍有关。  |  Paul, MS., et al. 2023. Am J Hum Genet. 110: 120-145. PMID: 36528028
  10. eIF4A1和eIF4A2在B细胞发育和功能中起着关键和不同的作用。  |  Du, Y., et al. 2025. Cell Mol Immunol. 22: 40-53. PMID: 39516355

订购信息

产品名称产品编号规格价格数量收藏夹

eIF4AII 抗体 (G-5)

sc-137147
200 µg/ml
RMB2377.00

eIF4AII (G-5): m-IgG Fc BP-HRP 套装

sc-539947
200 µg Ab; 10 µg BP
RMB2662.00

eIF4AII (G-5): m-IgG2b BP-HRP 套装

sc-549757
200 µg Ab; 10 µg BP
RMB2662.00

eIF4AII (G-5) 中和勝肽

sc-137147 P
100 µg/0.5 ml
RMB511.00

What application is the blocking peptide sc-137147 P appropriate for?

Asked by: jerojero
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from great antibody for wbthe background was clean and the result is clear :)
Date published: 2017-07-03
Rated 5 out of 5 by from Good WB antibody in HeLa whole cell lysatesGood WB antibody in HeLa whole cell lysates and mouse brain tissue extract. -SCBT QC
Date published: 2015-05-10
Rated 5 out of 5 by from Strong cytoplasmic localization in HeLa cellsStrong cytoplasmic localization in HeLa cells in IF. -SCBT QC
Date published: 2015-03-31
Rated 5 out of 5 by from Worked well in IF in hamster BHK cellsWorked well in IF in hamster BHK cells. -SCBT Publication Review
Date published: 2015-01-30
Rated 5 out of 5 by from Antibody worked well in WB in 293T wholeAntibody worked well in WB in 293T whole cell lysates. -SCBT QC
Date published: 2015-01-19
Rated 5 out of 5 by from Good specificity in WB in rat blood samplesGood specificity in WB in rat blood samples. -SCBT Publication Review
Date published: 2013-09-09
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eIF4AII 抗体 (G-5) is rated 5.0 out of 5 by 6.
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