Date published: 2025-9-8
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eIF3β Antibody (B-6) - Western Blotting - Image 359296
eIF3β 抗体 (B-6): sc-271539. HeLa (A), Ca Ski (B), MCF7 (C), SH-SY5Y (D), Jurkat (E) 和 A-431 (F) 全细胞裂解液中 eIF3β 表达的 Western 印迹分析.
eIF3β 抗体 (B-6): sc-271539. HeLa (A), Ca Ski (B), MCF7 (C), SH-SY5Y (D), Jurkat (E) 和 A-431 (F) 全细胞裂解液中 eIF3β 表达的 Western 印迹分析.

eIF3β 抗体 (B-6): sc-271539

4.6(5)
寫評論提問

说明书
  • eIF3β抗体(B-6)是小鼠单克隆IgG1 κ, 在6篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的eIF3β的C-terminus附近的氨基酸215-242之间
  • 推荐用于 mouse, rat， human 和 avian 来源的eIF3β WB, IP, IF 和 ELISA检测; 也和以下物种反应，包括： 和 canine, bovine and avian
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是eIF3β Antibody (B-6) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与eIF3β Antibody (B-6) 打包提供（请参阅下面的订购信息）。

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研究信息

関連項目

附加eIF抗体，包括eIF1, eIF1AY, eIF2 α, eIF2B α, eIF2B β, eIF2B δ, eIF2B ε, eIF2 β, eIF2B γ, eIF2C, eIF2C2, eIF2C4, eIF2D, eIF3 p110, eIF3 α和eIF3 β

真核细胞中蛋白质合成的启动受到蛋白质起始因子和RNA分子之间相互作用的调控。真核起始因子（eIFs）在一系列反应中被利用，最终导致80S核糖体组装，并最终进行翻译。真核起始因子-3（eIF3）支架结构是eIF复合物中最大的，包括eIF3α、eIF3β、eIF3γ、eIF3δ、eIF3ε、eIF3Ω、eIF3η和eIF3θ，所有这些都起着控制40S核糖体亚基组装的作用。eIF3蛋白与40S核糖体亚基的结合稳定了eIF2-GTP-Met-tRNAiMet复合物的结合和mRNA的结合，并促进80S核糖体解离为40S和60S亚基，从而促进预启动复合物的组装。eIF3蛋白在多种癌症中普遍过表达，提示eIF3蛋白在肿瘤发生中起作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

eIF3β 抗体 (B-6) 参考文献:

  1. RNA干扰介导的真核翻译起始因子3亚基B（EIF3B）基因表达沉默抑制结肠癌细胞的增殖。  |  Wang, Z., et al. 2012. World J Surg Oncol. 10: 119. PMID: 22734884
  2. 新型RNA结合蛋白P311结合真核翻译起始因子3亚基b（eIF3b）以促进转化生长因子β1-3（TGF-β1-3）的翻译。  |  Yue, MM., et al. 2014. J Biol Chem. 289: 33971-83. PMID: 25336651
  3. 真核翻译起始因子3亚基B在肝癌中的表达及其预后意义。  |  Yue, Q., et al. 2020. Exp Ther Med. 20: 436-446. PMID: 32537008
  4. 真核翻译起始因子3亚基B是前列腺癌中的一种新型致癌因子。  |  Xiang, P., et al. 2020. Mamm Genome. 31: 197-204. PMID: 32556998
  5. 减毒白喉毒素介导 siRNA 递送。  |  Arnold, AE., et al. 2020. Sci Adv. 6: PMID: 32917630
  6. 真核翻译起始因子3亚基B是胰腺癌发展和进展的启动子。  |  Ren, H., et al. 2021. Front Oncol. 11: 644156. PMID: 33996561
  7. 真核翻译起始因子3亚基B可作为乳腺癌的潜在预后预测因子。  |  Song, S., et al. 2022. Bioengineered. 13: 2762-2776. PMID: 35040374
  8. 真核翻译起始因子3亚基B通过CEBPB翻译促进头颈癌的发生。  |  Xu, C., et al. 2022. Cancer Cell Int. 22: 161. PMID: 35459206
  9. YTHDF2通过ETV5/PD-L1/VEGFA轴抑制免疫逃逸和血管生成，是肝癌的治疗靶点。  |  Wen, J., et al. 2024. Adv Sci (Weinh). 11: e2307242. PMID: 38247171
  10. 新型TIPARP抑制剂可恢复缺血性中风中的线粒体功能和脑损伤。  |  Cai, Y., et al. 2024. Pharmacol Res. 210: 107508. PMID: 39547463

订购信息

产品名称产品编号规格价格数量收藏夹

eIF3β 抗体 (B-6)

sc-271539
200 µg/ml
RMB2377.00

eIF3β (B-6): m-IgG Fc BP-HRP 套装

sc-537658
200 µg Ab; 10 µg BP
RMB2662.00

eIF3β (B-6): m-IgGκ BP-HRP 套装

sc-534992
200 µg Ab; 40 µg BP
RMB2662.00

eIF3β (B-6): m-IgG1 BP-HRP 套装

sc-545287
200 µg Ab; 20 µg BP
RMB2662.00

eIF3β (B-6) 中和勝肽

sc-271539 P
100 µg/0.5 ml
RMB511.00

What application is the blocking peptide sc-271539 P appropriate for?

Asked by: jenniferc
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from Good data obtained by Western Blot and immunoprecipitationGood data obtained by Western Blot and immunoprecipitation using human MDA-MB-231, MDA-MB-468 and Caco- 2 cells. -SCBT Publication Review
Date published: 2015-05-12
Rated 4 out of 5 by from Product scProduct sc-271539 was found to be suitable for detection of stress granules in B.manjavacas samples via immunohistochemistry. -SCBT Publication Review
Date published: 2015-05-12
Rated 5 out of 5 by from Good antibody for mouse MEF cells when analyzedGood antibody for mouse MEF cells when analyzed by Western Blot. -SCBT Publication Review
Date published: 2015-02-23
Rated 5 out of 5 by from Publishable data obtained by Western BlotPublishable data obtained by Western Blot, immunohistochemistry and immunofluorescence using the following samples: mouse mandibles,bones,T4 4,MC3T3-E1,C3H10T1/2,HMSCs,preodontoblasts,preosteoblasts. -SCBT Publication Review
Date published: 2015-02-14
Rated 5 out of 5 by from Strong signal observed by Western Blot usingStrong signal observed by Western Blot using LADMAC, Ca Ski, HeLa and T24 whole cell lysates. -SCBT QC
Date published: 2013-01-22
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eIF3β 抗体 (B-6) is rated 4.6 out of 5 by 5.
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