EGF/FGF/PDGF receptor tyrosine kinase inhibitor 抑制剂 (CAS 1135256-66-4)

物理状态 :

Solid

溶解度 :

Soluble in DMSO (25 mg/ml), and ethanol (1 mg/ml).

保存 :

Store at 4° C

熔点 :

256.77° C (Predicted)

沸点 :

594.56° C (Predicted)

密度 :

~1.4 g/cm³ (Predicted)

折射率 :

n²⁰_D 1.69 (Predicted)

IC50 :

Flg: IC₅₀ = 0.15 µM (human); PDGFR-β: IC₅₀ = 0.18 µM (human); Platelet-derived growth factor receptor : IC₅₀ = 0.63 µM (rat); c-Src: IC₅₀ = 1.76 µM (human); EGFR: IC₅₀ = 5.47 µM (human)

pK值 :

pK_a: 9.85 (Predicted), pK_b: 2.59 (Predicted)

PubChem CID :

SMILES :

CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=C(C=CC=C3Cl)Cl