Date published: 2025-9-7

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E2F-3 抗体 (PG14): sc-69683

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说明书
  • E2F-3抗体(PG14)是小鼠单克隆IgG2a κ, 在2篇文献中引用,规格为200 µg/ml
  • 免疫human物种的重组E2F-3
  • 推荐用于 mouse, rat 和 human 来源的E2F-3 WB 和 IP检测
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRP是E2F-3 Antibody (PG14) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与E2F-3 Antibody (PG14) 打包提供(请参阅下面的订购信息)。

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関連項目

人视网膜母细胞瘤基因产物似乎在细胞增殖的负调控中发挥重要作用。Rb的功能失活可以通过突变或由与DNA肿瘤病毒编码的蛋白质相互作用引起。在迄今为止描述的所有Rb关联中,Rb与转录因子E2F之间复合物的鉴定最直接地将Rb与细胞增殖的调控联系起来。E2F最初是通过其在腺病毒E2启动子的转录激活中的作用而被鉴定的。在许多编码具有细胞周期G1和S期假定功能的蛋白质的基因的上游发现了与E2F结合位点同源的序列。E2F-1是包括E2F-2、E2F-3、E2F-4、E2F-5、E2F-6和E2F-7在内的更广泛的转录调节因子家族的成员,每个成员都与第二种蛋白质DP-1形成异二聚体,形成"活性"的E2F转录调节复合物。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

E2F-3 抗体 (PG14) 参考文献:

  1. 利用基于 siRNA (E2F3) 的基因沉默技术抑制乳腺癌中 E2F3 的过表达。  |  Vimala, K., et al. 2012. Arch Med Res. 43: 415-22. PMID: 22960857
  2. 肿瘤巨噬细胞中的 E2f3 可促进肺转移。  |  Trikha, P., et al. 2016. Oncogene. 35: 3636-46. PMID: 26549026
  3. MicroRNA-770-5p通过靶向糖尿病肾病中的E2F3促进荚膜细胞损伤  |  Guo, J., et al. 2020. Braz J Med Biol Res. 53: e9360. PMID: 32696822
  4. Circ-E2F3 作为 miR-204-5p 的 ceRNA,通过调节 ROCK1 的表达促进视网膜母细胞瘤的增殖、转移和凋亡抑制。  |  Huang, Y., et al. 2021. Exp Mol Pathol. 120: 104637. PMID: 33844975
  5. 基质硬度通过 E2F3 依赖性信号调节肝星状细胞活化为肿瘤促进肌成纤维细胞,并调控恶性进展。  |  Liu, Z., et al. 2021. Cell Death Dis. 12: 1134. PMID: 34873170
  6. rtcisE2F通过N6-甲基腺苷依赖的E2F3/E2F6 mRNA稳定性促进肝脏肿瘤诱导细胞的自我更新和转移。  |  Chen, Z., et al. 2022. Sci China Life Sci. 65: 1840-1854. PMID: 35266112
  7. CircKRT14 通过与 miR-1256 相互作用上调 E2F3,成为食管癌的致癌因子。  |  Guan, X., et al. 2023. Hum Exp Toxicol. 42: 9603271231155093. PMID: 36738282
  8. CDK4-E2F3 信号可增强氧化骨骼肌纤维的数量和功能,从而影响肌生成和新陈代谢。  |  Bahn, YJ., et al. 2023. J Clin Invest. 133: PMID: 37395281
  9. E2F-3 的积累受多肽稳定性的调节。  |  Flores, AM., et al. 1998. Oncogene. 16: 1289-98. PMID: 9546430

订购信息

产品名称产品编号规格价格数量收藏夹

E2F-3 抗体 (PG14)

sc-69683
200 µg/ml
RMB2377.00

E2F-3 (PG14): m-IgG Fc BP-HRP 套装

sc-539218
200 µg Ab; 10 µg BP
RMB2662.00

E2F-3 (PG14): m-IgG2a BP-HRP 套装

sc-546683
200 µg Ab; 10 µg BP
RMB2662.00

I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with E2F-3 (PG14): sc-69683?

Asked by: TinTin
We recommend using one of our our exclusive Mouse IgG Binding Proteins conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support
Date published: 2017-03-01
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Rated 4 out of 5 by from Good specificity in WB in human transfectedGood specificity in WB in human transfected 293 and HeLa whole cell lysates. -SCBT QC
Date published: 2015-04-28
Rated 4 out of 5 by from Single strong band in WB in KSingle strong band in WB in K-562 and Y79 whole cell lysates and K-562, Y79 and PMA treated Y79 nuclear extracts. -SCBT QC
Date published: 2015-03-05
Rated 4 out of 5 by from Good publishable data in WB in human cellGood publishable data in WB in human cell lines Saos2, U2OS, HCT116, H1299, and MDAH041. -SCBT Publication Review
Date published: 2014-05-02
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E2F-3 抗体 (PG14) is rated 4.0 out of 5 by 3.
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