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Dynamin II 抗体 (B-2): sc-166526

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  • Dynamin II抗体(B-2)是小鼠单克隆IgG1 κ, 在6篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Dynamin II的C-terminus的氨基酸853-870之间
  • 推荐用于 mouse, rat 和 human 来源的Dynamin II WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: 和 equine, bovine, porcine and canine; 可能与 Dynamin III产生交联反应
  • 看 Dynamin II (G-4): sc-166669,可查看有标记的 Dynamin II 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgGκ BP-HRP是Dynamin II Antibody (B-2) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与Dynamin II Antibody (B-2) 搭配使用(请参阅下面的订购信息)。有关其它 m-IgGκ BP 结合物,请参阅我们完整的小鼠 IgG 结合蛋白列表。
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Dynamin家族的成员,包括Dynamin I和Dynamin II,是GPTase、微管相关蛋白,它们参与内吞作用、突触传递和神经发生。Dynamin I定位于中枢神经系统,而Dynamin II则普遍分布,其中在睾丸中的表达量最高。两种dynamin蛋白都含有SH3和富含脯氨酸的结构域,这些结构域介导dynamins与其GTPase活性的效应器之间的相互作用。与这些效应器的相互作用,包括微管、酸性磷脂和含SH3结构域的蛋白质,是快速内吞作用所必需的。Dynamin I似乎通过SH3结构域与amphiphysin(一种在脑中高表达的蛋白质)的相互作用被募集到网格蛋白包被的凹坑中。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Dynamin II 抗体 (B-2) 参考文献:

  1. 溶血磷脂酸介导的Grb2(生长因子受体结合蛋白2)结合型动态胺Ⅱ的酪氨酸磷酸化。  |  Kranenburg, O., et al. 1999. Biochem J. 339 (Pt 1): 11-4. PMID: 10085221
  2. 达纳明 II 结构域的表达和纯化以及结构和功能的初步研究。  |  Dong, J., et al. 2000. Protein Expr Purif. 20: 314-23. PMID: 11049755
  3. 增加与动态素 II 的 GTP 结合不会刺激受体介导的内吞。  |  Jeong, MJ., et al. 2001. Biochem Biophys Res Commun. 283: 136-42. PMID: 11322780
  4. 在人肝癌 HepG2 细胞中,Grb2 与达能素 II 呈显性结合。  |  Yoon, SY., et al. 2001. J Cell Biochem. 84: 150-5. PMID: 11746524
  5. 埃可病毒 1 进入腔隙体的内吞需要脂质筏、达能素 II 和信号事件。  |  Pietiäinen, V., et al. 2004. Mol Biol Cell. 15: 4911-25. PMID: 15356270
  6. 在小鼠牙齿发育过程中,达纳明 II 在颌骨细胞中的表达。  |  Oh, JH., et al. 2011. J Nanosci Nanotechnol. 11: 7096-9. PMID: 22103132
  7. 限制脑暴露但保留达明敏 II 活性的丙氯丙嗪 PEG 化脂质体制剂: 接受化疗 mAbs 的癌症患者的潜在辅助疗法。  |  Subasic, CN., et al. 2024. Nanomedicine. 56: 102733. PMID: 38199450
  8. 分离广泛表达的 cDNA,编码大型 GTP 结合蛋白家族成员--人类达纳明 II。  |  Diatloff-Zito, C., et al. 1995. Gene. 163: 301-6. PMID: 7590285
  9. 在获得成熟胰腺尖突细胞表型的过程中,达纳明-II的表达上调。  |  Cook, TA., et al. 1996. J Histochem Cytochem. 44: 1373-8. PMID: 8985129
  10. 在 Ras 转化的 NIH3T3 细胞中,动态素 II 与 Grb2 SH3 结构域相关联。  |  Yoon, SY., et al. 1997. Biochem Biophys Res Commun. 234: 539-43. PMID: 9175747

订购信息

产品名称产品编号规格价格数量收藏夹

Dynamin II 抗体 (B-2)

sc-166526
200 µg/ml
CNY2422.00

Dynamin II (B-2): m-IgGκ BP-HRP 套装

sc-551981
200 µg Ab; 40 µg BP
CNY2715.00

Dynamin II (B-2) 中和勝肽

sc-166526 P
100 µg/0.5 ml
CNY519.00

This antibody works in zebrafish samples for WB and immunofluorescense?

Asked by: Anonymous
Thank you for your question. This antibody has not yet been tested in zebrafish and so that is not a recommended species at this time. Check back for updates!
Answered by: Tech Service
Date published: 2020-11-10

What application is the blocking peptide sc-166526 P appropriate for?

Asked by: jenniferc
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by Duanyang_Xie from This has worked well in WBThis has worked well in WB.
Date published: 2015-11-25
Rated 5 out of 5 by SS from WB publishable data with murine B16WB publishable data with murine B16-F10 cells - SCBT Publication Review
Date published: 2015-01-09
Rated 5 out of 5 by MS from Produced beautiful immunofluorescence cytoplasmicProduced beautiful immunofluorescence cytoplasmic staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2013-07-25
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Dynamin II 抗体 (B-2) is rated 4.7 out of 5 by 3.
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