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DRP1 Antibody (6Z-82) - Western Blotting - Image 34629
DRP1 抗体 (6Z-82): sc-101270. K-562 全细胞裂解液中 DRP1 表达的 Western 印迹分析.
DRP1 抗体 (6Z-82): sc-101270. K-562 全细胞裂解液中 DRP1 表达的 Western 印迹分析.

DRP1 抗体 (6Z-82): sc-101270

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说明书
  • DRP1抗体(6Z-82)是小鼠单克隆IgG2b κ, 在38篇文献中引用，规格为100 µg/ml
  • 免疫human物种的重组DRP1
  • 推荐用于 mouse, rat 和 human 来源的DRP1 WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 DRP1 (C-5): sc-271583，可查看有标记的 DRP1 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 2b BP-HRP">m-IgG2b BP-HRP和m-IgGκ BP-HRP是DRP1 Antibody (6Z-82) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与DRP1 Antibody (6Z-82) 打包提供（请参阅下面的订购信息）。
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DRP抗体

DRP1抗体（6Z-82）是一种IgG2b κ小鼠单克隆DRP1抗体，可通过WB、IP、IF、IHC（P）和ELISA检测来自小鼠、大鼠和人的DRP1。DRP1抗体（6Z-82）为非偶联抗DRP1抗体形式。Dynamin相关蛋白1（DRP1）介导哺乳动物细胞的外线粒体膜裂变。DRP1也被称为Dynamin样蛋白1（Dlp1）、DVLP或Dymple。DRP1包含Dynamin超家族GTP酶特有的N端三分子GTP结合域。DRP1以T形二聚体的形式存在，包含头部、腿部和茎部。GTP的加入诱导头部和茎部的重新排列，产生一种力，最终导致膜收缩。DRP1在骨骼肌、心脏、肾脏和大脑中表达丰富，无处不在。在细胞中，DRP1定位于核周区域。在小鼠大脑中，DRP1在小脑中高度表达，尤其是在小脑浦肯野细胞中。在细胞凋亡过程中，DRP1从细胞质转移到线粒体，并定位到潜在的细胞器分裂位点。抑制DRP可避免细胞死亡，这表明线粒体裂变在细胞凋亡中起着关键作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

DRP1 抗体 (6Z-82) 参考文献:

  1. 昼夜节律控制DRP1活性调节线粒体动力学和生物能。  |  Schmitt, K., et al. 2018. Cell Metab. 27: 657-666.e5. PMID: 29478834
  2. Drp1在心脏线粒体自噬和细胞死亡中的作用。  |  Tong, M., et al. 2020. J Mol Cell Cardiol. 142: 138-145. PMID: 32302592
  3. PINK1 磷酸化 Drp1S616，调节线粒体的有丝分裂依赖性动态。  |  Han, H., et al. 2020. EMBO Rep. 21: e48686. PMID: 32484300
  4. 心血管疾病中 Drp1 依赖性线粒体分裂。  |  Jin, JY., et al. 2021. Acta Pharmacol Sin. 42: 655-664. PMID: 32913266
  5. ERK1/2介导的DRP1激活调节线粒体动力学和软骨细胞凋亡  |  Ansari, MY., et al. 2022. Osteoarthritis Cartilage. 30: 315-328. PMID: 34767958
  6. MIROs 和 DRP1 驱动线粒体衍生囊泡的生物生成并促进质量控制。  |  König, T., et al. 2021. Nat Cell Biol. 23: 1271-1286. PMID: 34873283
  7. DRP1直接与BAX相互作用，诱导其活化和凋亡。  |  Jenner, A., et al. 2022. EMBO J. 41: e108587. PMID: 35023587
  8. Drp1增加通过mtDNA应激介导的cGAS-STING通路促进自噬和ESCC进展。  |  Li, Y., et al. 2022. J Exp Clin Cancer Res. 41: 76. PMID: 35209954
  9. 肝脏DRP1的缺失会诱发巨线粒体和线粒体适应不良，从而加重酒精性肝炎。  |  Ma, X., et al. 2023. Hepatology. 77: 159-175. PMID: 35698731
  10. DRP1在肥胖性心肌病中常规和替代性线粒体自噬中的独特作用。  |  Tong, M., et al. 2023. Circ Res. 133: 6-21. PMID: 37232152

订购信息

产品名称产品编号规格价格数量收藏夹

DRP1 抗体 (6Z-82)

sc-101270
100 µg/ml
CNY2550.00

DRP1 (6Z-82): m-IgGκ BP-HRP 套装

sc-534541
100 µg Ab; 40 µg BP
CNY2715.00

DRP1 (6Z-82): m-IgG2b BP-HRP 套装

sc-549265
100 µg Ab; 10 µg BP
CNY2715.00

Can I use sc-101270 for my porcine samples?

Asked by: Cweed
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 13
Date published: 2017-01-26
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Rated 4 out of 5 by Anonymous from antibodyGood antibody by Western blotting using human samples.
Date published: 2019-08-19
Rated 5 out of 5 by jianwei Sun from works very wellI bought this antibody for western blot, it works very well
Date published: 2018-03-17
Rated 5 out of 5 by 小新贝贝 from Quite good antibody!1:200 diluted for rat wb ,the band is quite strong !
Date published: 2017-12-30
Rated 5 out of 5 by Konj from DRP1 AntibodyIt is a wonderful antibody. This antibody recognizes oligomers formed by DRP1.
Date published: 2017-03-24
Rated 5 out of 5 by sticky from A specific band above 75KD was observed50 ug of homogenized mouse heart from wt were loaded onto 10% gel. primary anti-OPA1 anbody was diluted at 1:1000, and anti-mouse IgG-HRP was diluted at 1:5000.A specific band above 75KD was observed at wt samples.
Date published: 2017-02-14
Rated 5 out of 5 by Professor Griffin from Great antibodyDRP1 Antibody (6Z-82) was used for WB and IHCP. Observed nice expected band and specific staining
Date published: 2017-01-23
Rated 5 out of 5 by SM from Strong clear band in transfected 293T wholeStrong clear band in transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-05-07
Rated 5 out of 5 by TS from CleanClean, clear band in western blot analysis of DRP1 expression in K-562 whole cell lysate. -SCBT QC
Date published: 2015-04-12
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DRP1 抗体 (6Z-82) is rated 4.9 out of 5 by 9.
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