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DOCK 4 Antibody (R6Y) - Western Blotting - Image 34091
DOCK 4 抗体 (R6Y): sc-100718. 对 HeLa 核提取物中 DOCK 4 的表达进行 Western 印迹分析.
DOCK 4 抗体 (R6Y): sc-100718. 对 HeLa 核提取物中 DOCK 4 的表达进行 Western 印迹分析.

DOCK 4 抗体 (R6Y): sc-100718

3.7(3)
寫評論提問

说明书
  • DOCK 4 抗体 R6Y 是小鼠单克隆 IgG2b κ，DOCK 4抗体, 在7篇文献中引用，规格为50 µg/0.5 ml
  • 免疫human物种的重组DOCK 4
  • 推荐用于 mouse, rat 和 human 来源的DOCK 4 WB, IP, IF, IHC(P) 和 ELISA检测
  • 关于如何获取DOCK 4 (R6Y): sc-100718的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成DOCK 4 抗体 (R6Y)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

DOCK 4 抗体 (R6Y)是一种IgG2b κ型小鼠单克隆DOCK 4抗体(也称DOCK 4抗体)，通过WB、IP、IF、IHC(P)和ELISA等方法检测小鼠、大鼠和人源的DOCK 4蛋白。DOCK 4抗体(R6Y)是一种非偶联的抗DOCK 4抗体。DOCK 4(胞质分裂奉献蛋白4)是一种胞质外周膜蛋白，属于胞质分裂调节蛋白DOCK家族。DOCK 4在前列腺、卵巢和骨骼肌中表达最为广泛，作为一种鸟嘌呤核苷酸交换因子(GEF)激活小gtp酶Rap 1，并通过这种激活在细胞间黏附连接的调节中发挥作用。与其他DOCK家族成员相似，DOCK 4包含一个n端SH3结构域，一个c端富含脯氨酸的区域，以及两个DOCK内部的同源区域DHR1和DHR2。编码DOCK 4的基因缺陷导致Rap 1失活，因此与多种癌症的发病机制有关，如卵巢癌、前列腺癌、胶质瘤和结直肠癌。由于选择性剪接事件，DOCK 4的四种亚型被表达。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

DOCK 4 抗体 (R6Y) 参考文献:

  1. 鉴定具有鸟嘌呤核苷酸交换活性的 DOCK180 相关蛋白进化保守超家族。  |  Côté, JF. and Vuori, K. 2002. J Cell Sci. 115: 4901-13. PMID: 12432077
  2. DOCK4是一种GTP酶激活剂，在肿瘤发生过程中被破坏。  |  Yajnik, V., et al. 2003. Cell. 112: 673-84. PMID: 12628187
  3. GTPase 调节器 DOCK4 的一种异构体定域于内耳的立体纤毛，并与谐蛋白（USH1C）结合。  |  Yan, D., et al. 2006. J Mol Biol. 357: 755-64. PMID: 16464467
  4. Dock4 受 RhoG 调节，促进 Rac 依赖性细胞迁移。  |  Hiramoto, K., et al. 2006. Exp Cell Res. 312: 4205-16. PMID: 17027967
  5. DOCK2 和 DOCK9 鸟嘌呤核苷酸交换因子对 Rac2 和 Cdc42 的特异性识别。  |  Kwofie, MA. and Skowronski, J. 2008. J Biol Chem. 283: 3088-3096. PMID: 18056264

订购信息

产品名称产品编号规格价格数量收藏夹

DOCK 4 抗体 (R6Y)

sc-100718
50 µg/0.5 ml
RMB2504.00

I want to know the immunogen sequence of sc-100718: DOCK4 (R6Y) monoclonal antibody, could you tell me?

Asked by: daji
Thank you for your question. The exact epitope recognized by this monoclonal antibody has not been determined. However, the immunogen is mapping within the last 100 amino acids at the C-terminus of DOCK 4 of human origin.
Answered by: Technical Support
Date published: 2018-12-24

Can sc-100718: DOCK 4 (R6Y) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: AbPolly
Thank you for your question. Yes, sc-100718: DOCK 4 (R6Y) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from Good for multiple assaysThis antibody has been used for western blot and immunofluorescence in published research. -SCBT QC
Date published: 2023-09-14
Rated 3 out of 5 by from Satisfactory immunoperoxidase membrane stainingSatisfactory immunoperoxidase membrane staining in formalin-fixed, paraffin-embedded human breast cancer tissue. -SCBT QC
Date published: 2015-03-16
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DOCK 4抗体 (R6Y) is rated 3.7 out of 5 by 3.
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