Date published: 2025-9-8

021-6093-6350

SCBT Portrait Logo
Seach Input

DNase I 抗体 (D-1): sc-374207

3.7(3)
寫評論提問

说明书
  • DNase I抗体(D-1)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于mouse物种的DNase l的内部区域内的氨基酸73-88之间
  • 推荐用于 mouse 和 rat 来源的DNase I WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是DNase I Antibody (D-1) for WB applications. 的首选辅助检测试剂,这些试剂现与DNase I Antibody (D-1) 打包提供(请参阅下面的订购信息)。

    快捷链接

    関連項目

    在核酸内切酶激活后,核小体间DNA片段化是细胞凋亡的共同终点。DNase I是一种在哺乳动物组织中普遍表达的Ca2+/Mg2+依赖性核酸内切酶,已被证实可介导人细胞凋亡过程中的核小体间DNA降解。DNase I具有高度多态性,目前已知至少有六种DNase I等位基因。DNase II是一种普遍表达的酸性脱氧核糖核酸酶,在caspase激活后发挥作用,也可能在细胞凋亡过程中诱导DNA消化。DNase I将DNA裂解为5'-磷酸二核苷酸和5'-磷酸寡核苷酸终产物,而DNase II则将DNA裂解为3'-磷酸单核苷酸和3'-磷酸寡核苷酸终产物。DNase II切割DNA的机制与DNase I相似,产生的是切口而非双链切割。DNase II通常存在于上皮细胞的细胞质中,但在晶状体纤维的细胞核中似乎更为集中。相比之下,DNase I总是集中在上皮和纤维细胞的细胞核中。编码DNase II的基因定位于人类19号染色体上。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    DNase I 抗体 (D-1) 参考文献:

    1. DNAse-I 对缺血/再灌注诱发急性肾损伤大鼠模型的肾保护作用  |  Peer, V., et al. 2016. Am J Nephrol. 43: 195-205. PMID: 27073834
    2. DNase γ、DNase I 和 Caspase-activated DNase 相互合作,降解死亡细胞。  |  Koyama, R., et al. 2016. Genes Cells. 21: 1150-1163. PMID: 27654959
    3. DNase I 可改善糖尿病小鼠的角膜上皮和神经再生。  |  Zhang, J., et al. 2020. J Cell Mol Med. 24: 4547-4556. PMID: 32168430
    4. DNase I 可改善血乳屏障的完整性,减轻金黄色葡萄球菌在乳腺炎期间诱发的炎症。  |  Jingjing, W., et al. 2021. Int Immunopharmacol. 100: 108079. PMID: 34455255
    5. iDHS-FFLG:通过特征融合和局部-全局特征提取网络识别 DNase I 超敏位点。  |  Wang, LS. and Sun, ZL. 2023. Interdiscip Sci. 15: 155-170. PMID: 36166165
    6. 水凝胶递送 DNase I 和脂质体万古霉素,用于消除骨折相关的耐甲氧西林金黄色葡萄球菌感染并支持骨质疏松性骨折愈合。  |  Li, J., et al. 2023. Acta Biomater. 164: 223-239. PMID: 37019168
    7. 五味子素 A 和 DNase I 基因敲除通过降低细胞内钙浓度对高糖诱导的β细胞凋亡有协同作用  |  Bin, Z., et al. 2023. J Tradit Chin Med. 43: 661-666. PMID: 37454250
    8. 基因工程细胞纳米微粒作为靶向 DNase I 运送系统,用于清除急性肺损伤中的中性粒细胞胞外陷阱  |  Du, Y., et al. 2023. Adv Sci (Weinh). 10: e2303053. PMID: 37759381
    9. DNase I 可靶向降解中性粒细胞胞外捕获器,减少对 IgAV 大鼠的损伤。  |  Chen, XQ., et al. 2023. PLoS One. 18: e0291592. PMID: 37906560
    10. 细胞外的 G 型四联体和 Z 型 DNA 可保护生物膜免受 DNase I 的破坏,G 型四联体可形成一种具有过氧化物酶活性的 DNA 酶。  |  Minero, GAS., et al. 2024. Nucleic Acids Res. 52: 1575-1590. PMID: 38296834

    订购信息

    产品名称产品编号规格价格数量收藏夹

    DNase I 抗体 (D-1)

    sc-374207
    200 µg/ml
    RMB2377.00

    DNase I (D-1): m-IgG Fc BP-HRP 套装

    sc-540425
    200 µg Ab; 10 µg BP
    RMB2662.00

    DNase I (D-1): m-IgG1 BP-HRP 套装

    sc-542112
    200 µg Ab; 20 µg BP
    RMB2662.00

    DNase I (D-1) 中和勝肽

    sc-374207 P
    100 µg/0.5 ml
    RMB511.00

    What application is the blocking peptide sc-374207 P appropriate for?

    Asked by: jerojero
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-24
    • y_2025, m_9, d_7, h_4CST
    • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasquestionsanswers, tq_1
    • loc_zh_CN, sid_374207, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getContent, 143ms
    • QUESTIONS, PRODUCT
    Rated 1 out of 5 by from DNase1 mRNA is not expressed in NIH3T3 and RAW263DNase1 is not expressed at mRNA levels according to the database BioGPS, despite the Western blot data in this Web page.
    Date published: 2022-07-25
    Rated 5 out of 5 by from Exceptional immunofluorescence cytoplasmicExceptional immunofluorescence cytoplasmic staining in methanol-fixed NIH/3T3 cells. -SCBT QC
    Date published: 2015-03-13
    Rated 5 out of 5 by from Good Western Blot data of DNase I expressionGood Western Blot data of DNase I expression in non-transfected and mouse DNase I transfected 293T whole cell lysates. -SCBT QC
    Date published: 2013-05-29
    • y_2025, m_9, d_7, h_4
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_3
    • loc_zh_CN, sid_374207, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getReviews, 19ms
    • REVIEWS, PRODUCT
    DNase I 抗体 (D-1) is rated 3.7 out of 5 by 3.
    • y_2025, m_9, d_7, h_4
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_3
    • loc_zh_CN, sid_374207, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getAggregateRating, 130ms
    • REVIEWS, PRODUCT