Date published: 2026-10-26

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Dhh 抗体 (F-8): sc-137101

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说明书
  • Dhh抗体(F-8)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于human物种的Dhh的N-terminus附近的氨基酸54-97之间
  • 推荐用于 mouse, rat 和 human 来源的the amino-terminal subunit of Dhh WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是Dhh Antibody (F-8) for WB applications. 的首选辅助检测试剂,这些试剂现与Dhh Antibody (F-8) 打包提供(请参阅下面的订购信息)。
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    関連項目

    果蝇的节段极性基因hedgehog(hh)编码一种前体蛋白,该蛋白经过自切割生成氨基端和羧基端肽。这两种蛋白质都被分泌出来,似乎在胚胎和成虫盘模式中发挥作用。已经鉴定出几种果蝇hh的脊椎动物同源物。这些包括Sonic hedgehog(Shh)(或者称为Vhh-1)、Desert hedgehog(Dhh)和Indian hedgehog(Ihh)。每一种都含有氨基端信号肽,并显然作为分泌蛋白参与介导各种细胞-细胞相互作用。Shh与果蝇hh相似,因为它被加工生成一种氨基端分泌肽,该肽保留在细胞表面或附近,以及一种羧基端糖基化、更易扩散的肽。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    Dhh 抗体 (F-8) 参考文献:

    1. 性发育的控制  |  Biason-Lauber, A. 2010. Best Pract Res Clin Endocrinol Metab. 24: 163-86. PMID: 20541146
    2. 对 DNA 复制因子 Cdc45 结构和功能的深入研究揭示了其与 DHH 磷酸酯酶家族的进化关系。  |  Krastanova, I., et al. 2012. J Biol Chem. 287: 4121-8. PMID: 22147708
    3. 自闭症谱系障碍中的血清沙漠刺猬蛋白水平:初步结果。  |  Bashir, S., et al. 2014. Med Princ Pract. 23: 14-7. PMID: 24009062
    4. 精原细胞干细胞: 鉴定、增殖和分化。  |  Chen, H., et al. 2017. Mol Cell Endocrinol. 445: 65-73. PMID: 27743991
    5. GdpP催化结构域的结构和生化特征揭示了DHH/DHHA1磷酸二酯酶的统一水解机制  |  Wang, F., et al. 2018. Biochem J. 475: 191-205. PMID: 29203646
    6. GATA4/6在大鼠肾上腺皮质自体移植中调节DHH转录。  |  Yoshida, T., et al. 2020. Sci Rep. 10: 446. PMID: 31949236
    7. 全长 Dhh 和 N 端 Shh 可作为竞争性拮抗剂调节血管生成和血管通透性。  |  Hollier, PL., et al. 2021. Cardiovasc Res. 117: 2489-2501. PMID: 33063110
    8. 表达Dhh的Schwann细胞前体有助于皮肤和耳蜗黑素细胞,但不适用于前庭黑素细胞。  |  Bonnamour, G., et al. 2021. Pigment Cell Melanoma Res. 34: 648-654. PMID: 33089656
    9. PRUNE-1条件性基因敲除等位基因的产生  |  Wu, X., et al. 2023. Cells. 12: PMID: 36831191
    10. PRUNE1综合征的神经影像学:文献小评。  |  Scorrano, G., et al. 2023. Front Neurol. 14: 1301147. PMID: 38178891

    订购信息

    产品名称产品编号规格价格数量收藏夹

    Dhh 抗体 (F-8)

    sc-137101
    200 µg/ml
    $322.00

    Dhh (F-8): m-IgG Fc BP-HRP 套装

    sc-539934
    200 µg Ab; 10 µg BP
    $361.00

    Dhh (F-8): m-IgG1 BP-HRP 套装

    sc-541796
    200 µg Ab; 20 µg BP
    $361.00

    Dhh (F-8) 中和勝肽

    sc-137101 P
    100 µg/0.5 ml
    $69.00

    What application is the blocking peptide sc-137101 P appropriate for?

    Asked by: Trav11
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-27
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    Rated 5 out of 5 by MC from Satisfactory Western blot data of Dhh expressionSatisfactory Western blot data of Dhh expression in non-transfected and human Dhh transfected 293T whole cell lysates. -SCBT QC
    Date published: 2014-09-07
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    Dhh 抗体 (F-8) is rated 5.0 out of 5 by 1.
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