Date published: 2025-10-24
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δ-catenin Antibody (40.1) - Western Blotting - Image 33443
δ-catenin (40. 1): sc-81793. PC-12 全细胞裂解液中 δ-catenin 表达的 Western 印迹分析.
δ-catenin Antibody (40.1) - Western Blotting - Image 33443
δ-catenin (40. 1): sc-81793. PC-12 全细胞裂解液中 δ-catenin 表达的 Western 印迹分析.
δ-catenin Antibody (40.1) - Western Blotting - Image 368188
δ-catenin抗体 (40. 1): sc-81793. C6 全细胞裂解液中 δ-catenin 表达的 Western 印迹分析.
δ-catenin (40. 1): sc-81793. PC-12 全细胞裂解液中 δ-catenin 表达的 Western 印迹分析.

δ-catenin 抗体 (40.1): sc-81793

4.3(6)
寫評論提問

说明书
  • delta-catenin 抗体 40.1 是小鼠单克隆 IgG1 κ，δ-catenin抗体, 在12篇文献中引用，规格为100 µg/ml
  • 针对部分重组蛋白，其氨基酸序列在δ-catenin的human起源的1081-1191范围内
  • 推荐用于 mouse, rat 和 human 来源的δ-catenin WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG Fc BP-HRP和 1 BP-HRP">m-IgG1 BP-HRP是δ-catenin Antibody (40.1) for WB and IHC(P) applications. 的首选辅助检测试剂，这些试剂现与δ-catenin Antibody (40.1) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

附加Catenin抗体，包括α E-catenin, α T-catenin, β-catenin, δ-catenin和γ-catenin

δ-catenin 抗体 (40.1) 是一种小鼠单克隆 IgG1 kappa 轻链抗体，可通过蛋白质印迹 (WB)、免疫沉淀 (IP)、免疫荧光 (IF)、石蜡包埋切片免疫组织化学 (IHCP) 和酶联免疫吸附测定 (ELISA) 检测小鼠、大鼠和人类来源的δ-catenin 蛋白。抗-delta-catenin抗体（40.1）以非结合形式提供。Delta-catenin是catenin家族的一员，在调节细胞粘附和信号通路方面发挥着关键作用，特别是在大脑中，delta-catenin与阿尔茨海默病相关蛋白presenilin 1相互作用。Delta-catenin在中枢神经系统中的存在凸显了其在神经元发育和突触功能中的重要性。值得注意的是，编码delta-catenin的基因位于人类染色体5p15.2上，而半合子缺失该基因与Cri-du-Chat综合征有关，这是一种以发育迟缓和智力障碍为特征的遗传性疾病。Delta-catenin与其他连接蛋白（如α-catenin和β-catenin）的相互作用进一步强调了delta-catenin在维持细胞完整性和通信方面的作用。此外，与钙粘蛋白/钙粘蛋白复合物结合的跨膜磷酸酶PTPm可以调节对细胞反应至关重要的信号通路。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

δ-catenin 抗体 (40.1) 参考文献:

  1. delta-catenin（CTNND2）半杂合子与cri-du-chat综合征的严重智力迟钝有关。  |  Medina, M., et al. 2000. Genomics. 63: 157-64. PMID: 10673328
  2. 环形RNA EIF4G3通过促进δ-catenin泛素降解和上调SIK1来抑制β-catenin，从而抑制胃癌进展。  |  Zang, X., et al. 2022. Mol Cancer. 21: 141. PMID: 35780119
  3. δ-Catenin通过层特异性星形细胞-神经元钙粘蛋白相互作用控制星形细胞形态发生。  |  Tan, CX., et al. 2023. J Cell Biol. 222: PMID: 37707499
  4. 人类乳腺癌细胞系中 E-cadherin, α-和β-catenin 表达的频繁变化。  |  Pierceall, WE., et al. 1995. Oncogene. 11: 1319-26. PMID: 7478552
  5. E-cadherin/alpha-catenin 复合物在调节侵袭性结肠癌细胞的细胞-细胞和细胞-基质粘附特性中的作用。  |  Breen, E., et al. 1995. Ann Surg Oncol. 2: 378-85. PMID: 7496831
  6. 受体蛋白酪氨酸磷酸酶 PTPmu 在体内与粘附蛋白和 catenins 相关联。  |  Brady-Kalnay, SM., et al. 1995. J Cell Biol. 130: 977-86. PMID: 7642713
  7. 鉴定与 N-粘连蛋白和 alpha-catenin 结合所需的 plakoglobin 结构域。  |  Sacco, PA., et al. 1995. J Biol Chem. 270: 20201-6. PMID: 7650039
  8. α-肌动蛋白通过α-卡替宁与粘连蛋白/卡替宁细胞-细胞粘附复合体相互作用。  |  Knudsen, KA., et al. 1995. J Cell Biol. 130: 67-77. PMID: 7790378
  9. β-catenin在人类癌症中的表达。  |  Takayama, T., et al. 1996. Am J Pathol. 148: 39-46. PMID: 8546224
  10. 克隆缺乏第四个犰狳重复的 plakoglobin（γ-catenin）的替代形式。  |  Ozawa, M., et al. 1995. J Biochem. 118: 836-40. PMID: 8576101
  11. Presenilin 1 在大脑中与犰狳家族新成员的相互作用  |  Zhou, J., et al. 1997. Neuroreport. 8: 2085-90. PMID: 9223106
  12. delta-catenin是一种粘连结相关蛋白，可促进细胞分散。  |  Lu, Q., et al. 1999. J Cell Biol. 144: 519-32. PMID: 9971746

订购信息

产品名称产品编号规格价格数量收藏夹

δ-catenin 抗体 (40.1)

sc-81793
100 µg/ml
RMB2504.00

δ-catenin (40.1): m-IgG Fc BP-HRP 套装

sc-539664
100 µg Ab; 10 µg BP
RMB2662.00

δ-catenin (40.1): m-IgG1 BP-HRP 套装

sc-541644
100 µg Ab; 20 µg BP
RMB2662.00

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 2
Date published: 2017-02-15
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Rated 4 out of 5 by from very nice productI used d-catenin for IF, the antibody diluted at 1:100 and incubated 3h at room temperature. I used the secondary Goat anti mouse IgG (H+L) Alexa Fluor 488 at dilution 1:500 for 1h. I obtained a good clear staining.
Date published: 2021-04-30
Rated 2 out of 5 by from Very low titer, not specific in ICCThe antibody does recognize a single band of the appropriate size on WB. But I had to use 1:100 to get any signal at all. In ICC the antibody does not work as it generates equal signal in non-expressing cells (e.g. NIH/3T3) and positive control cells (neurons).
Date published: 2017-10-30
Rated 5 out of 5 by from Works well in Western BlotClean band seen at the appropriate weight for delta-catenin with no background in Western Blot.
Date published: 2017-01-23
Rated 5 out of 5 by from Human lung cancer IHC paraffin publishable dataHuman lung cancer IHC paraffin publishable data. -SCBT Publication Review
Date published: 2015-03-15
Rated 5 out of 5 by from Good data with paraffinGood data with paraffin-embedded human eyes tissue.-SCBT Publication Review
Date published: 2015-01-23
Rated 5 out of 5 by from Great monoclonal antibodyGreat monoclonal antibody, works perfect for WB with PC-12. -SCBT QC
Date published: 2013-06-23
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δ-catenin 抗体 (40.1) is rated 4.3 out of 5 by 6.
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