Date published: 2025-9-8

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Dab2 抗体 (B-3): sc-133077

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说明书
  • Dab2抗体(B-3)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 免疫human物种的Dab2的氨基酸661-770
  • 推荐用于 mouse, rat 和 human 来源的Dab2 WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是Dab2 Antibody (B-3) for WB applications. 的首选辅助检测试剂,这些试剂现与Dab2 Antibody (B-3) 打包提供(请参阅下面的订购信息)。

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    関連項目

    Dab2抗体(B-3)是一种小鼠单克隆IgG1抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附测定(ELISA)等方法检测小鼠、大鼠和人类样本中的Dab2。Dab2,也称为DOC-2,是一种对有丝分裂原反应的磷蛋白,在细胞信号传导和生长调节中起着至关重要的作用。Dab2主要位于细胞质中,通过与GRB2蛋白的SH3结构域结合,从而影响各种信号通路,起到生长负调节剂的作用。Dab2在细胞中的位置使其能够调节生长因子和其他信号分子,这对于维持正常的细胞功能和防止细胞无序增殖至关重要。此外,Dab2还会经历翻译后修饰,包括磷酸化,这可以进一步调节Dab2的活性及其与其他蛋白的相互作用。Dab2能够与GRB2等蛋白相互作用,这凸显了其在细胞信号网络中的重要性,使其成为发育生物学和癌症研究的重要研究对象。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    Dab2 抗体 (B-3) 参考文献:

    1. 鼻咽癌中,假定的肿瘤抑制基因DAB2经常因启动子甲基化而下调。  |  Tong, JH., et al. 2010. BMC Cancer. 10: 253. PMID: 20525238
    2. 人类癌症中dab2的频繁丢失表达和启动子高甲基化:荟萃分析和系统综述。  |  Zhang, Z., et al. 2014. Pak J Med Sci. 30: 432-7. PMID: 24772157
    3. Disabled-2(Dab2)在疾病中的作用。  |  Ogbu, SC., et al. 2021. Gene. 769: 145202. PMID: 33059028
    4. 免疫调节中残疾同源物2(DAB2)的新兴作用。  |  Figliuolo da Paz, V., et al. 2020. Front Immunol. 11: 580302. PMID: 33178208
    5. SOX6和DAB2在恶性间皮瘤诊断中的效用。  |  Naso, JR., et al. 2021. Am J Surg Pathol. 45: 1245-1251. PMID: 33782226
    6. 巨蛋白、立方体蛋白和Dab2驱动肾近曲小管细胞的胞吞作用。  |  Rbaibi, Y., et al. 2023. Mol Biol Cell. 34: ar74. PMID: 37126375
    7. RepID通过在DAB2启动子中招募CRL4A-JARID1A来抑制巨核细胞分化。  |  Jo, JH., et al. 2023. Cell Commun Signal. 21: 219. PMID: 37612584
    8. STAT3通过SRC-YAP1信号轴介导的DAB2上调促进幽门螺杆菌驱动的胃癌发生。  |  Duan, Y., et al. 2024. Biomark Res. 12: 33. PMID: 38481347
    9. 早期子痫前期子宫螺旋动脉重塑中DAB2和CXCL8的作用鉴定。  |  Liu, Y., et al. 2024. Cell Mol Life Sci. 81: 180. PMID: 38613672
    10. 支架蛋白残疾2(DAB2)及其在肿瘤发展和进展中的作用。  |  Pandya, DV., et al. 2024. Mol Biol Rep. 51: 701. PMID: 38822973

    订购信息

    产品名称产品编号规格价格数量收藏夹

    Dab2 抗体 (B-3)

    sc-133077
    200 µg/ml
    RMB2377.00

    Dab2 (B-3): m-IgG Fc BP-HRP 套装

    sc-539842
    200 µg Ab; 10 µg BP
    RMB2662.00

    Dab2 (B-3): m-IgG1 BP-HRP 套装

    sc-541745
    200 µg Ab; 20 µg BP
    RMB2662.00

    I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with Dab2 (B-3): sc-133077?

    Asked by: Dr Ninau Qelp
    We recommend using one of our our exclusive Mouse IgG Binding Proteins conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
    Answered by: Technical Support
    Date published: 2017-02-27
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    Rated 3 out of 5 by from It is not very goodI used this antibody to do western, it looks not good, there are a lot of unspecific band. But I used this antibody to do IP, it works fine.
    Date published: 2017-11-20
    Rated 5 out of 5 by from Satisfactory Western Blot data of Dab2 expressionSatisfactory Western Blot data of Dab2 expression in HeLa and H4 whole cell lysates. -SCBT QC
    Date published: 2015-04-20
    Rated 5 out of 5 by from Produced positive Western Blot data of Dab2Produced positive Western Blot data of Dab2 expression in rat embryo tissue extract. -SCBT QC
    Date published: 2013-12-21
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    Dab2 抗体 (B-3) is rated 4.3 out of 5 by 3.
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