Date published: 2025-9-6

021-6093-6350

SCBT Portrait Logo
Seach Input

Cytokeratin 17 抗体 (E-4): sc-393002

4.8(9)
寫評論提問

说明书
  • Cytokeratin 17抗体(E-4)是小鼠单克隆IgG2b κ, 在22篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列392-432位于human物种的Cytokeratin 17的C-terminus
  • 抗-Cytokeratin 17 抗体 (E-4) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 Cytokeratin 17
  • 抗Cytokeratin 17抗体(E-4)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Cytokeratin 17 (E-4): sc-393002免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP2b BP-HRP">m-IgG2b BP-HRPm-IgGκ BP-HRP是Cytokeratin 17 Antibody (E-4) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与Cytokeratin 17 Antibody (E-4) 打包提供(请参阅下面的订购信息)。

快捷链接

関連項目

细胞角蛋白17抗体(E-4)是一种IgG2b κ小鼠单克隆细胞角蛋白17抗体(也称为细胞角蛋白17抗体或KRT17抗体),可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人类来源的细胞角蛋白17。细胞角蛋白17抗体(E-4)可以作为非偶联的抗细胞角蛋白17抗体形式,以及多种偶联形式的抗细胞角蛋白17抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。细胞角蛋白17(也称为KRT17抗体,角蛋白17抗体)是中间丝蛋白(IFP)的细胞角蛋白亚家族的成员。它的独特之处在于它通常在复合上皮细胞的基底细胞中表达,而不是在分层或简单上皮细胞中表达。细胞角蛋白17含有432个氨基酸,在甲床、毛囊、皮脂腺和其他表皮附属物中表达。细胞角蛋白17通过与接头蛋白14-3-3-sigma相互作用来调节蛋白质合成,从而调节细胞生长和大小。编码细胞角蛋白17的基因突变导致蛋白质翻译减少和皮肤角质形成细胞变小,与Akt/mTOR信号活性的降低相对应。细胞角蛋白17可能是宫颈癌干细胞鉴定、喉鳞状细胞癌、呼吸道合胞病毒和人类泌尿道移行细胞癌的有用标志物。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cytokeratin 17 抗体 (E-4) 参考文献:

  1. 细胞角蛋白 17 通过 NF-kappaB 激活在感染呼吸道合胞病毒的细胞中表达,并与细胞病理合胞体的形成有关。  |  Domachowske, JB., et al. 2000. J Infect Dis. 182: 1022-8. PMID: 10979895
  2. 双羟萘醇和二甲基富马酸盐可抑制干扰素-γ 诱导的细胞角蛋白 17(一种假定的牛皮癣自身抗原)体外上调。  |  Bonnekoh, B., et al. 2001. Skin Pharmacol Appl Skin Physiol. 14: 217-25. PMID: 11464104
  3. 单纯疱疹病毒 2 型 US3 蛋白激酶对细胞角蛋白 17 的磷酸化作用。  |  Murata, T., et al. 2002. Microbiol Immunol. 46: 707-19. PMID: 12477250
  4. 细胞角蛋白 17 和 p63 是 HPV 靶细胞--宫颈干细胞的标记。  |  Martens, JE., et al. 2004. Anticancer Res. 24: 771-5. PMID: 15161025
  5. 作为喉鳞状细胞癌潜在标志物的细胞角蛋白-17。  |  Cohen-Kerem, R., et al. 2004. Ann Otol Rhinol Laryngol. 113: 821-7. PMID: 15535145
  6. 细胞角蛋白 17 表达与口腔鳞状细胞癌分化的关系  |  Kitamura, R., et al. 2012. J Cancer Res Clin Oncol. 138: 1299-310. PMID: 22466643
  7. BerEp4、细胞角蛋白14和细胞角蛋白17免疫组织化学染色有助于区分基底细胞癌和基底细胞癌伴鳞状上皮化生。  |  Linskey, KR., et al. 2013. Arch Pathol Lab Med. 137: 1591-8. PMID: 24168496
  8. 头颈癌中细胞角蛋白 17 表达的减少预示着结节转移和不良预后:第一个证据。  |  Xu, ES., et al. 2018. Clin Otolaryngol. 43: 1010-1018. PMID: 29495101
  9. 细胞角蛋白 17 基因的隐性增强子激活沉默的人类细胞角蛋白 17 伪基因启动子区域。  |  Troyanovsky, SM. and Leube, RE. 1994. Eur J Biochem. 225: 61-9. PMID: 7523124
  10. 细胞角蛋白 17 在人类泌尿道过渡细胞癌中的免疫组织化学定位。  |  Guelstein, VI., et al. 1993. Virchows Arch B Cell Pathol Incl Mol Pathol. 64: 1-5. PMID: 7691361
  11. 干扰素γ控制细胞角蛋白17的表达  |  Vogel, U. and Böttger, EC. 1995. Immunobiology. 193: 322-7. PMID: 8530161

订购信息

产品名称产品编号规格价格数量收藏夹

Cytokeratin 17 抗体 (E-4)

sc-393002
200 µg/ml
RMB2377.00

Cytokeratin 17 (E-4): m-IgG Fc BP-HRP 套装

sc-530333
200 µg Ab; 10 µg BP
RMB2662.00

Cytokeratin 17 (E-4): m-IgGκ BP-HRP 套装

sc-523772
200 µg Ab, 40 µg BP
RMB2662.00

Cytokeratin 17 (E-4): m-IgG2b BP-HRP 套装

sc-550179
200 µg Ab; 10 µg BP
RMB2662.00

Cytokeratin 17 抗体 (E-4) AC

sc-393002 AC
500 µg/ml, 25% agarose
RMB3129.00

Cytokeratin 17 抗体 (E-4) HRP

sc-393002 HRP
200 µg/ml
RMB2377.00

Cytokeratin 17 抗体 (E-4) FITC

sc-393002 FITC
200 µg/ml
RMB2482.00

Cytokeratin 17 抗体 (E-4) PE

sc-393002 PE
200 µg/ml
RMB2580.00

Cytokeratin 17 抗体 (E-4) Alexa Fluor® 488

sc-393002 AF488
200 µg/ml
RMB2685.00

Cytokeratin 17 抗体 (E-4) Alexa Fluor® 546

sc-393002 AF546
200 µg/ml
RMB2685.00

Cytokeratin 17 抗体 (E-4) Alexa Fluor® 594

sc-393002 AF594
200 µg/ml
RMB2685.00

Cytokeratin 17 抗体 (E-4) Alexa Fluor® 647

sc-393002 AF647
200 µg/ml
RMB2685.00

Cytokeratin 17 抗体 (E-4) Alexa Fluor® 680

sc-393002 AF680
200 µg/ml
RMB2685.00

Cytokeratin 17 抗体 (E-4) Alexa Fluor® 790

sc-393002 AF790
200 µg/ml
RMB2685.00

Do you have feedback from people using Cytokeratin 17 Antibody (E-4): sc-393002 on mouse tissue? Skin?

Asked by: Edwige
Thank you for your question. We do not have received any publications that cite use of this antibody with mouse skin, but based on our tests with this antibody we recommend and warranty it for this use. You can also contact our technical service for a free sample of this antibody.
Answered by: Tech Support Europe
Date published: 2020-08-26

I am using Cytokeratin 17 (E-4): sc-393002 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: DefinitelyNotMatt
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
  • y_2025, m_8, d_31, h_8CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_zh_CN, sid_393002, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 113ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Ottimo anticorpo per fluorescenzaHo acquistato il campione prova, testato su HEK (CTRL-) e HeLa (CTRL+) in immunofluorescenza. Funziona benissimo.
Date published: 2018-11-05
Rated 5 out of 5 by from Good!Worked very well on normal epithelial cells, IF staining.
Date published: 2018-07-24
Rated 5 out of 5 by from Sehr gute Ergebnisse in der ImmunfluoreszenzGratisprobe erhalten; sehr gute Ergebnisse in der Immunfluoreszenz an Kryoschnitten humaner Gewebe; gute und spezifische Reaktion.
Date published: 2018-05-07
Rated 5 out of 5 by from Great antibodyIt works very wel for detecting basal cells from bronchi. Used on paraffin-embedded lung sections.
Date published: 2018-02-16
Rated 4 out of 5 by from 抗体挺好用work well in PC3 cells, IF used at 1:100,WB used at 1:1000
Date published: 2017-07-25
Rated 4 out of 5 by from Antibody specificity is not very good.The antibody specificity is not very good,The results of westernblot is unsatisfactory,there are many complex banding.
Date published: 2017-01-12
Rated 5 out of 5 by from Great staining with paraffinGreat staining with paraffin-embedded human skin tissue. -SCBT QC
Date published: 2015-02-15
Rated 5 out of 5 by from Works well for IF applicationsWorks well for IF applications, positive in HeLa. -SCBT QC
Date published: 2015-01-10
  • y_2025, m_8, d_31, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_9
  • loc_zh_CN, sid_393002, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 10ms
  • REVIEWS, PRODUCT
Cytokeratin 17抗体 (E-4) is rated 4.8 out of 5 by 9.
  • y_2025, m_8, d_31, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_9
  • loc_zh_CN, sid_393002, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 107ms
  • REVIEWS, PRODUCT