Date published: 2026-10-24

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Cyr61/CCN1 抗体 (H-2): sc-271217

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说明书
  • Cyr61/CCN1抗体(H-2)是小鼠单克隆IgG1 κ, 在5篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Cyr61的C-terminus的氨基酸345-381之间
  • 推荐用于 human 来源的Cyr61 WB, IP, IF 和 ELISA检测
  • 看 Cyr61/CCN1 (A-10): sc-374129,可查看有标记的 Cyr61/CCN1 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是Cyr61/CCN1 Antibody (H-2) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Cyr61/CCN1 Antibody (H-2) 打包提供(请参阅下面的订购信息)。
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Cyr61是一种由生长因子诱导的即刻早期基因编码的分泌型肝素结合蛋白,与细胞外基质和结缔组织相关。Cyr61是一个独特的促血管生成和血管生成调节因子家族的成员,被指定为CCN蛋白,其中包括结缔组织生长因子(CTGF)和小鼠Cyr61同源物Fisp12。作为一种血管生成诱导剂,Cyr61与细胞表面受体整合素αV/β3结合,然后刺激细胞粘附和迁移,并促进人血管内皮细胞的DNA合成。Cyr61在血管生长、伤口愈合和软骨细胞分化过程中表达升高。Cyr61在多种肿瘤中也有发现,因为它能诱导肿瘤生长,并作为肿瘤进展的标志物。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cyr61/CCN1 抗体 (H-2) 参考文献:

  1. Cyr61/CTGF/Nov家族蛋白在胃癌发生中的作用。  |  Cheng, TY., et al. 2014. World J Gastroenterol. 20: 1694-700. PMID: 24587648
  2. Cyr61/CCN1靶向胰腺癌的化学敏感性。  |  Banerjee, S., et al. 2019. Oncotarget. 10: 3579-3580. PMID: 31217893
  3. CCN1/CYR61在肺部疾病中的作用。  |  Zhu, Y., et al. 2020. Int J Mol Sci. 21: PMID: 33105556
  4. Solamargine通过抑制LIF/miR-192-5p/CYR61/Akt信号通路和诱发免疫刺激肿瘤微环境诱导肝细胞癌细胞凋亡和自噬。  |  Yin, S., et al. 2022. J Hematol Oncol. 15: 32. PMID: 35313929
  5. 慢性鼻-鼻窦炎伴鼻息肉患者鼻上皮细胞增殖中,CYR61表达的增加激活了CCND1/c-Myc通路。  |  Luo, C., et al. 2023. Clin Immunol. 247: 109235. PMID: 36681101
  6. 妊娠期砷暴露对小鼠胎盘和胎儿发育的影响:Cyr61 m6A的作用。  |  Song, YP., et al. 2023. Environ Health Perspect. 131: 97004. PMID: 37682722
  7. 肝细胞CYR61使成纤维化巨噬细胞分化,以协调NASH纤维化。  |  Mooring, M., et al. 2023. Sci Transl Med. 15: eade3157. PMID: 37756381
  8. TGF-β和YAP信号上调CYR61对肝细胞癌产生反抑制作用。  |  Zhang, C., et al. 2024. J Biol Chem. 300: 107208. PMID: 38521502
  9. Cyr61在骨折修复过程中促进血管生成。  |  Lang, A., et al. 2024. bioRxiv.. PMID: 38617208
  10. CYR61作为细胞内微管相关蛋白,通过PLK1-FBW7途径协调有丝分裂进程。  |  Hu, K., et al. 2024. Int J Biol Sci. 20: 3140-3155. PMID: 38904029

订购信息

产品名称产品编号规格价格数量收藏夹

Cyr61/CCN1 抗体 (H-2)

sc-271217
200 µg/ml
CNY2422.00

Cyr61/CCN1 (H-2): m-IgG Fc BP-HRP 套装

sc-537590
200 µg Ab; 10 µg BP
CNY2715.00

Cyr61/CCN1 (H-2): m-IgGκ BP-HRP 套装

sc-534898
200 µg Ab; 40 µg BP
CNY2715.00

Cyr61/CCN1 (H-2): m-IgG1 BP-HRP 套装

sc-545248
200 µg Ab; 20 µg BP
CNY2715.00

Cyr61/CCN1 (H-2) 中和勝肽

sc-271217 P
100 µg/0.5 ml
CNY519.00

Does this detect mouse CCN1?

Asked by: Bob27
Thank you for your question.sc-271217 has only been validated for human samples.
Answered by: BlakeJ
Date published: 2026-09-17

What application is the blocking peptide sc-271217 P appropriate for?

Asked by: DefinitelyNotMatt
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-25
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Rated 5 out of 5 by FL from Nice Western Blot data of Cyr61 expression in nonNice Western Blot data of Cyr61 expression in non-transfected and human Cyr61 transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-05-19
Rated 5 out of 5 by TO from Produced positive Western Blot data of Cyr61Produced positive Western Blot data of Cyr61 expression in MDA-MB-231 whole cell lysate. -SCBT QC
Date published: 2013-07-31
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Cyr61/CCN1 抗体 (H-2) is rated 5.0 out of 5 by 2.
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