Date published: 2025-9-7

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CYP26A1 抗体 (F27 P6 A1): sc-53618

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说明书
  • CYP26A1 抗体 F27 P6 A1 是小鼠单克隆 IgG κ,CYP26A1抗体, 在11篇文献中引用,规格为200 µg/ml
  • 针对CYP26A1的human起源的C-terminus的
  • CYP26A1 抗体 (F27 P6 A1) 推荐用于 WB, IP, IF 和 IHC(P),检测mouse, rat 和human 来源的 CYP26A1
  • 抗CYP26A1抗体(F27 P6 A1)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取CYP26A1 (F27 P6 A1): sc-53618免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 是 CYP26A1 抗体 (F27 P6 A1) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与CYP26A1 抗体 (F27 P6 A1) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

CYP26A1 抗体(F27 P6 A1)是一种小鼠单克隆 IgG 抗体,可通过免疫印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和石蜡包埋切片免疫组织化学(IHCP)检测小鼠、大鼠和人源的 CYP26A1 蛋白。CYP26A1 (F27 P6 A1) 抗体有非共轭型和多种共轭型,包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 共轭物。CYP26A1 又称视黄酸-4-羟化酶,是视黄酸分解代谢的关键酶,对调节发育过程和维持细胞平衡至关重要。通过催化视黄酸羟化,CYP26A1 有助于调节视黄酸水平,防止胚胎发育过程中的致畸效应。这种调节可保护尾芽组织免受不适当的视黄酸水平的影响,不适当的视黄酸水平可导致严重的发育异常。CYP26A1 的转录受核维甲酸受体 β2 的表观遗传调控,突显了复杂的表达调控机制。CYP26A1 基因突变与多种先天性疾病有关,包括尾骨发育不全和脊柱裂,凸显了其在发育生物学中的重要意义。CYP26A1 在某些肿瘤(如大肠腺瘤性息肉病小鼠腺瘤和人类散发性结肠癌)中上调,这表明它在癌症生物学中具有潜在的作用并可作为治疗靶点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CYP26A1 抗体 (F27 P6 A1) 参考文献:

  1. 以致命的 RA 水平进行发育:Rarg 的基因消减可恢复缺乏 Cyp26a1 的小鼠的活力。  |  Abu-Abed, S., et al. 2003. Development. 130: 1449-59. PMID: 12588859
  2. 在眼睛后期发育过程中,CYP26A1 和 CYP26C1 在赤道视网膜内合作降解视黄酸。  |  Sakai, Y., et al. 2004. Dev Biol. 276: 143-57. PMID: 15531370
  3. 人 NB4 早幼粒细胞白血病细胞中选择性 RAR 和 RXR 激动剂对 CYP26A1 表达的调控。  |  Idres, N., et al. 2005. Biochem Pharmacol. 69: 1595-601. PMID: 15896339
  4. 结直肠癌细胞色素 p450 图谱:确定预后标志物。  |  Kumarakulasingham, M., et al. 2005. Clin Cancer Res. 11: 3758-65. PMID: 15897573
  5. 在调节 Cyp26A1 诱导性的过程中,遥远的维甲酸反应元件之间存在转录协同作用。  |  Loudig, O., et al. 2005. Biochem J. 392: 241-8. PMID: 16053444
  6. 对人类神经管缺陷中的 ALDH1A2, CYP26A1, CYP26B1, CRABP1 和 CRABP2 的分析表明,这可能与 ALDH1A2 中的等位基因有关。  |  Deak, KL., et al. 2005. Birth Defects Res A Clin Mol Teratol. 73: 868-75. PMID: 16237707
  7. 胚胎癌细胞中细胞色素 P450 Cyp26a1 受 RAR 介导的表观遗传学控制。  |  Pozzi, S., et al. 2006. Oncogene. 25: 1400-7. PMID: 16261163
  8. 尾椎退缩综合征患者 CYP26A1 基因的突变筛选。  |  De Marco, P., et al. 2006. Birth Defects Res A Clin Mol Teratol. 76: 86-95. PMID: 16463413
  9. 通过 WNT 依赖性机制上调腺瘤性息肉病大肠杆菌缺陷脊椎动物体内的 CYP26A1:对肠细胞分化和结肠肿瘤发生的影响。  |  Shelton, DN., et al. 2006. Cancer Res. 66: 7571-7. PMID: 16885356
  10. 糖皮质激素受体可抑制 CYP26A1 的转录,而 C/EBPβ 可增强或抑制 CYP26A1 的转录。  |  Yoo, HS., et al. 2022. iScience. 25: 104564. PMID: 35789854
  11. Cyp26a1 支持出生后视黄酸平衡和葡萄糖调节控制。  |  Yoo, HS., et al. 2023. J Biol Chem. 104669. PMID: 37011860
  12. 二甲双胍通过诱导Cyp26a1和CD8+ T细胞下调来减少肝癌的发生。  |  He, W., et al. 2023. Clin Transl Med. 13: e1465. PMID: 37997519

订购信息

产品名称产品编号规格价格数量收藏夹

CYP26A1 抗体 (F27 P6 A1)

sc-53618
200 µg/ml
$316.00

CYP26A1 (F27 P6 A1): m-IgG Fc BP-HRP 套装

sc-525612
200 µg Ab; 10 µg BP
$354.00

CYP26A1 抗体 (F27 P6 A1) AC

sc-53618 AC
500 µg/ml, 25% agarose
$416.00

CYP26A1 抗体 (F27 P6 A1) HRP

sc-53618 HRP
200 µg/ml
$316.00

CYP26A1 抗体 (F27 P6 A1) FITC

sc-53618 FITC
200 µg/ml
$330.00

CYP26A1 抗体 (F27 P6 A1) PE

sc-53618 PE
200 µg/ml
$343.00

CYP26A1 抗体 (F27 P6 A1) Alexa Fluor® 488

sc-53618 AF488
200 µg/ml
$357.00

CYP26A1 抗体 (F27 P6 A1) Alexa Fluor® 546

sc-53618 AF546
200 µg/ml
$357.00

CYP26A1 抗体 (F27 P6 A1) Alexa Fluor® 594

sc-53618 AF594
200 µg/ml
$357.00

CYP26A1 抗体 (F27 P6 A1) Alexa Fluor® 647

sc-53618 AF647
200 µg/ml
$357.00

CYP26A1 抗体 (F27 P6 A1) Alexa Fluor® 680

sc-53618 AF680
200 µg/ml
$357.00

CYP26A1 抗体 (F27 P6 A1) Alexa Fluor® 790

sc-53618 AF790
200 µg/ml
$357.00

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 7
Date published: 2017-01-26
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Rated 3 out of 5 by from Wrong AddressI bought this half a month ago and was really looking forward to using it but unfortunately SCB sent it to the wrong address 1000km away to another university and labeled the commercial invoice in such a way that it was considered a veterinary supply ( ie for mice!). After spending a few days waiting for the Canadian Food Inspection Agency to consent that this is not a vet reagent the antibody arrived just in time for my lab to be shutdown because of the pandemic. Just imagine all the beautiful work I could have done with this antibody
Date published: 2020-03-27
Rated 5 out of 5 by from Quality Ab - IF1:300 dilution, mouse pancreas. Quality IF staining. Would use again.
Date published: 2017-11-17
Rated 4 out of 5 by from Working antibody in WBThis CYP26A1 is working fine in mouse brain tissues. Background is clean and signal is strong.
Date published: 2017-10-13
Rated 5 out of 5 by from Good ABIt works pretty well for WB using mES cells at 1:1000 dilution.
Date published: 2017-07-06
Rated 5 out of 5 by from Recommended for IHC(P) and IFBeautiful Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue. Reference in the primary literature for Immunofluorescence on mouse samples.
Date published: 2016-12-16
Rated 5 out of 5 by from Robust staining in paraffinRobust staining in paraffin-embedded human liver tissue. -SCBT QC
Date published: 2015-02-10
Rated 5 out of 5 by from Single strong band in WB with human ovarySingle strong band in WB with human ovary tumor tissue extract. -SCBT QC
Date published: 2013-08-31
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CYP26A1 抗体 (F27 P6 A1) is rated 4.6 out of 5 by 7.
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