CYM 5442 hydrochloride CAS: 1094042-01-9
MF: C23H27N3O4•HCl
MW: 445.94
A potent, brain penetrant, and selective EDG-1 (S1P1) agonist.

CYM 5442 hydrochloride (CAS 1094042-01-9)

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Application: CYM 5442 hydrochloride is a potent, brain penetrant, and selective EDG-1 (S1P1) agonist
CAS Number: 1094042-01-9
Purity: ≥98%
Molecular Weight: 445.94
Molecular Formula: C23H27N3O4•HCl
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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CYM 5442 hydrochloride is a potent and selective EDG-1 (S1P1) agonist in vitro (EC50 = 1.35 nM). Shown to activate S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain penetrant.


参考文献

1. Gonzalez-Cabrera, P.J., et al. 2008. Mol. Pharmacol. 74: 1308-1318. PMID: 18708635

Physical State :
Solid
Solubility :
Soluble in water (10 mM), and DMSO (100 mM).
Storage :
Store at -20° C
IC50 :
S1P1: EC5050 = 1.35 nM
仅供科研使用。不可用于诊断或治疗。
SMILES :
Cl.OCCNC1CCC2C(CCCC12)C1NOC(N1)C1CCC(OCC)C(OCC)C1

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