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cylindromatosis 1 Antibody (H-6) - Western Blotting - Image 320926
圆柱瘤病 1 抗体 (H-6): sc-137139. 圆柱瘤病 1 在 MIA PaCa-2 (A), Jurkat (B), HeLa (C) 和 A-431 (D) 全细胞裂解液和小鼠脑组织提取物 (E) 中表达的 Western 印迹分析.
圆柱瘤病 1 抗体 (H-6): sc-137139. 圆柱瘤病 1 在 MIA PaCa-2 (A), Jurkat (B), HeLa (C) 和 A-431 (D) 全细胞裂解液和小鼠脑组织提取物 (E) 中表达的 Western 印迹分析.

cylindromatosis 1 抗体 (H-6): sc-137139

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寫評論提問

说明书
  • cylindromatosis 1 抗体 H-6 是小鼠单克隆 IgG2b κ，cylindromatosis 1抗体, 在12篇文献中引用，规格为200 µg/ml
  • 针对C-terminal的cylindromatosis 1的419个氨基酸的human来源
  • cylindromatosis 1 抗体 (H-6) 推荐用于 WB, IP, IF 和 ELISA，检测mouse, rat 和human 来源的 cylindromatosis 1
  • 抗cylindromatosis 1抗体（H-6）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取cylindromatosis 1 (H-6): sc-137139的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 2b BP-HRP">m-IgG2b BP-HRP和m-IgGκ BP-HRP是cylindromatosis 1 Antibody (H-6) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与cylindromatosis 1 Antibody (H-6) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

cylindromatosis 1抗体（H-6）是一种IgG2b κ小鼠单克隆cylindromatosis 1抗体（也称为cylindromatosis（头巾状肿瘤综合征）抗体、赖氨酸63去泛素化酶抗体、泛素特异性肽酶样2抗体、USPL2抗体、泛素特异性蛋白酶抗体或泛素羧基端水解酶抗体），可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的cylindromatosis 1蛋白。cylindromatosis 1抗体（H-6）既有非偶联抗cylindromatosis 1抗体形式，也有多种偶联形式的抗cylindromatosis 1抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。家族性圆柱瘤病是一种常染色体显性遗传病，易患多发性皮肤良性肿瘤，即圆柱瘤。这些圆柱瘤可能会感染，导致毁容和不适。在严重的情况下，溃疡性圆柱瘤只能通过皮肤移植的重建手术来治疗。人类16号染色体上的CYLD基因编码cylindromatosis 1蛋白。该基因的突变是导致家族性圆柱瘤病的原因。cylindromatosis 1蛋白含有三个细胞骨架相关蛋白-甘氨酸保守（CAP-GLY）结构域，可能起协调细胞器与微管附着的作用。cylindromatosis 1在脑、性腺、骨骼肌、脾、肝、心、肺和白细胞中表达。CYLD基因的体细胞突变似乎在具有圆柱状特征的肿瘤的发生中起作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

cylindromatosis 1 抗体 (H-6) 参考文献:

  1. 金属硫蛋白可防止长期接触镉金属硫化物所产生的肾毒性。  |  Liu, Y., et al. 1999. Toxicol Sci. 50: 221-7. PMID: 10478858
  2. 近端肾小管细胞受 Cd2+ 或 CdMT 影响而凋亡：不同的吸收途径以及内/溶酶体对 CdMT 的吸收所起的促进作用。  |  Erfurt, C., et al. 2003. Am J Physiol Cell Physiol. 285: C1367-76. PMID: 12890648
  3. SHARPIN 缺陷小鼠的免疫失调依赖于 CYLD 介导的细胞死亡。  |  Ang, RL., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34887354
  4. CYLD 缺乏会通过 PFKFB3 促进鼻咽癌的代谢重编程和肿瘤进展。  |  Wang, L., et al. 2022. Cancer Lett. 532: 215586. PMID: 35131382
  5. 子宫内膜癌中 CYLD 的表达及其与临床组织病理学参数的相关性。  |  Papadatou, V., et al. 2022. Taiwan J Obstet Gynecol. 61: 596-600. PMID: 35779906
  6. 肿瘤抑制因子 CYLD 失活抑制成纤维细胞重编程为多能性  |  Bekas, N., et al. 2023. Cancers (Basel). 15: PMID: 37894364
  7. CYLD通过去泛素化WNK1缓解NLRP3炎症体介导的骨质疏松症中的脓毒症。  |  Jiang, G., et al. 2024. J Orthop Surg Res. 19: 212. PMID: 38561786
  8. 去泛素化酶 CYLD 的连续表达不会影响小胶质细胞的表型或在稳态和神经炎症中的功能。  |  Schramm, E., et al. 2024. J Mol Med (Berl). 102: 1381-1393. PMID: 39302418
  9. CYLD通过去泛素化ENKD1和促进对感光细胞外段的吞噬作用来维持视网膜的稳态。  |  Yang, S., et al. 2024. Adv Sci (Weinh). 11: e2404067. PMID: 39373352
  10. 急性 CdMT 注射不是研究慢性镉肾病的良好模型：慢性氯化镉和 CdMT 暴露与大鼠急性 CdMT 注射的比较。  |  Liu, J., et al. 1998. Toxicol Appl Pharmacol. 153: 48-58. PMID: 9875299

订购信息

产品名称产品编号规格价格数量收藏夹

cylindromatosis 1 抗体 (H-6)

sc-137139
200 µg/ml
RMB2377.00

cylindromatosis 1 (H-6): m-IgGκ BP-HRP 套装

sc-521436
200 µg Ab, 40 µg BP
RMB2662.00

cylindromatosis 1 (H-6): m-IgG2b BP-HRP 套装

sc-548898
200 µg Ab; 10 µg BP
RMB2662.00

cylindromatosis 1 抗体 (H-6) AC

sc-137139 AC
500 µg/ml, 25% agarose
RMB3129.00

cylindromatosis 1 抗体 (H-6) HRP

sc-137139 HRP
200 µg/ml
RMB2377.00

cylindromatosis 1 抗体 (H-6) FITC

sc-137139 FITC
200 µg/ml
RMB2482.00

cylindromatosis 1 抗体 (H-6) PE

sc-137139 PE
200 µg/ml
RMB2580.00

cylindromatosis 1 抗体 (H-6) Alexa Fluor® 488

sc-137139 AF488
200 µg/ml
RMB2685.00

cylindromatosis 1 抗体 (H-6) Alexa Fluor® 546

sc-137139 AF546
200 µg/ml
RMB2685.00

cylindromatosis 1 抗体 (H-6) Alexa Fluor® 594

sc-137139 AF594
200 µg/ml
RMB2685.00

cylindromatosis 1 抗体 (H-6) Alexa Fluor® 647

sc-137139 AF647
200 µg/ml
RMB2685.00

cylindromatosis 1 抗体 (H-6) Alexa Fluor® 680

sc-137139 AF680
200 µg/ml
RMB2685.00

cylindromatosis 1 抗体 (H-6) Alexa Fluor® 790

sc-137139 AF790
200 µg/ml
RMB2685.00

Can cylindromatosis 1 (H-6): sc-137139 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Cweed
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, cylindromatosis 1 (H-6): sc-137139 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Excellent antibody!This is an excellent antibody for detecting CYLD in melanoma cell lines. I used it to detect several melanoma cell lines, the band is very specific and clear.
Date published: 2018-01-17
Rated 5 out of 5 by from Great features!I bought this last year and it has been working really well. Considering the molecular weight of CYLD is large, the band is really clear and there is no unspecific band around.
Date published: 2017-09-08
Rated 5 out of 5 by from Great!I bought this antibody for western blotting. I am so satisfied with it!
Date published: 2017-02-22
Rated 5 out of 5 by from Excellent choice for cylindromatosis 1Excellent choice for Western blot, strong and reliable. Great choice!
Date published: 2017-02-06
Rated 5 out of 5 by from 抗体效价很好antibody works well in 1:1000 dilute, WB in MEFs and BMDM cells
Date published: 2016-12-02
Rated 4 out of 5 by from Strong bands seen in WB using MIA PaCaStrong bands seen in WB using MIA PaCa-2, Jurkat, HeLa and A-431 whole cell lysates and mouse brain tissue extract. -SCBT QC
Date published: 2015-05-15
Rated 4 out of 5 by from Worked well with transfected lysate by WBWorked well with transfected lysate by WB. -SCBT QC
Date published: 2015-05-07
Rated 4 out of 5 by from Publishable data in WB using HCT116 colonPublishable data in WB using HCT116 colon cancer cells. -SCBT Publication Review
Date published: 2014-01-26
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cylindromatosis 1 抗体 (H-6) is rated 4.7 out of 5 by 9.
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