Date published: 2025-9-7
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Cyclophilin F Antibody (G-9) - Western Blotting - Image 358911
Cyclophilin F 抗体 (G-9): sc-376061. 拉莫斯 (A), HeLa (B) 和 Caco-2 (C) 全细胞裂解液中环嗜蛋白 F 表达的 Western 印迹分析.
Cyclophilin F 抗体 (G-9): sc-376061. 拉莫斯 (A), HeLa (B) 和 Caco-2 (C) 全细胞裂解液中环嗜蛋白 F 表达的 Western 印迹分析.

Cyclophilin F 抗体 (G-9): sc-376061

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说明书
  • Cyclophilin F 抗体 G-9 是小鼠单克隆 IgG1 κ，Cyclophilin F抗体, 在10篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的Cyclophilin F的C-terminus附近的氨基酸175-205之间
  • Cyclophilin F 抗体 (G-9) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 Cyclophilin F
  • 抗Cyclophilin F抗体（G-9）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Cyclophilin F (G-9): sc-376061的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 Cyclophilin F 抗体 (G-9) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Cyclophilin F 抗体 (G-9) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 Cyclophilin 抗体 包括 Cyclophilin E, Cyclophilin F, Cyclophilin G, CyPA, CyPB和Cyclophilin 40

Cyclophilin F抗体（G-9）是一种IgG1 κ小鼠单克隆Cyclophilin F抗体（也称为PPIF抗体），可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人类来源的Cyclophilin F蛋白。Cyclophilin F抗体（G-9）既可以是非偶联的抗Cyclophilin F抗体形式，也可以是多种偶联形式的抗Cyclophilin F抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Cyclophilins是保守的、普遍存在的且丰富的胞质肽基-脯氨酰顺反异构酶，可加速XaaPro肽键的异构化和蛋白质的重新折叠。人类cyclophilin A（CyPA）是一种由165个氨基酸组成的细胞内蛋白，是环孢菌素A（CsA）的靶向目标，由酵母到人类之间保守的单一独特基因编码。Cyclophilin B（CyPB）分泌于血液或乳汁等生物体液中，并与人类外周血淋巴细胞上存在的特异性受体结合，并在人类淋巴母细胞系Jurkat细胞中表达。Cyclophilin D（CyP40）是一种广泛表达的胞质蛋白，可催化寡肽中脯氨酸亚胺肽键的顺反异构化。Cyclophilin F（CyP3），也被称为PPIF、Cyp-D或Rotamase F，是一种由207个氨基酸组成的线粒体基质蛋白，通过激活线粒体通透性转换（mPT）孔参与诱导坏死和凋亡细胞死亡。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cyclophilin F 抗体 (G-9) 参考文献:

  1. 人类肽基脯氨酰-顺式-反式-异构酶线粒体前体基因的基因组特征：评估其在家族性扩张型心肌病中的作用。  |  Bowles, KR., et al. 1999. Hum Genet. 105: 582-6. PMID: 10647893
  2. 线粒体中无 Cyclophilin D 的通透性转换孔的特性。  |  Basso, E., et al. 2005. J Biol Chem. 280: 18558-61. PMID: 15792954
  3. 环嗜蛋白D的缺失揭示了线粒体通透性转换在细胞死亡中的关键作用。  |  Baines, CP., et al. 2005. Nature. 434: 658-62. PMID: 15800627
  4. rdh9（Crad3）表达的本体发育：消减会导致视黄醇和类固醇代谢酶发生变化，但 RXR 和雄激素信号似乎正常。  |  Hu, P., et al. 2007. Biochim Biophys Acta. 1770: 694-705. PMID: 17270348
  5. 突触线粒体中环嗜蛋白 D 含量高会导致更容易发生通透性转换。  |  Naga, KK., et al. 2007. J Neurosci. 27: 7469-75. PMID: 17626207
  6. 缺乏线粒体环纤蛋白酶 D 的小鼠焦虑症增强, 回避行为加剧，并出现成人肥胖症。  |  Luvisetto, S., et al. 2008. Neuroscience. 155: 585-96. PMID: 18621101
  7. 环嗜蛋白D缺乏症可减轻线粒体和神经元扰乱，并改善阿尔茨海默病的学习和记忆。  |  Du, H., et al. 2008. Nat Med. 14: 1097-105. PMID: 18806802
  8. 线粒体通透性转换孔在心脏病中的作用。  |  Halestrap, AP. and Pasdois, P. 2009. Biochim Biophys Acta. 1787: 1402-15. PMID: 19168026
  9. 环嗜蛋白 D 依赖性线粒体通透性转换在谷氨酸诱导的钙失调和兴奋性毒性神经元死亡中的作用  |  Li, V., et al. 2009. Exp Neurol. 218: 171-82. PMID: 19236863
  10. 氧化还原敏感的糖原合成酶激酶3β对线粒体通透性转变的控制：急性肾损伤的变阻调节。  |  Wang, Z., et al. 2013. Free Radic Biol Med. 65: 849-858. PMID: 23973862
  11. 饮食诱导的大鼠肥胖症中心脏脂毒性和线粒体氧化应激之间的相互作用。  |  Jiménez-González, S., et al. 2020. Cells. 9: PMID: 32079154
  12. 烟酰胺单核苷酸通过防止亲环蛋白F修饰和溶酶体功能障碍来保护小鼠败血症性心脏。  |  Ni, R., et al. 2024. Acta Pharmacol Sin.. PMID: 39623043

订购信息

产品名称产品编号规格价格数量收藏夹

Cyclophilin F 抗体 (G-9)

sc-376061
200 µg/ml
RMB2377.00

Cyclophilin F (G-9): m-IgG Fc BP-HRP 套装

sc-527505
200 µg Ab; 10 µg BP
RMB2662.00

Cyclophilin F (G-9): m-IgG1 BP-HRP 套装

sc-532878
200 µg Ab; 20 µg BP
RMB2662.00

Cyclophilin F 抗体 (G-9) AC

sc-376061 AC
500 µg/ml, 25% agarose
RMB3129.00

Cyclophilin F 抗体 (G-9) HRP

sc-376061 HRP
200 µg/ml
RMB2377.00

Cyclophilin F 抗体 (G-9) FITC

sc-376061 FITC
200 µg/ml
RMB2482.00

Cyclophilin F 抗体 (G-9) PE

sc-376061 PE
200 µg/ml
RMB2580.00

Cyclophilin F 抗体 (G-9) Alexa Fluor® 488

sc-376061 AF488
200 µg/ml
RMB2685.00

Cyclophilin F 抗体 (G-9) Alexa Fluor® 546

sc-376061 AF546
200 µg/ml
RMB2685.00

Cyclophilin F 抗体 (G-9) Alexa Fluor® 594

sc-376061 AF594
200 µg/ml
RMB2685.00

Cyclophilin F 抗体 (G-9) Alexa Fluor® 647

sc-376061 AF647
200 µg/ml
RMB2685.00

Cyclophilin F 抗体 (G-9) Alexa Fluor® 680

sc-376061 AF680
200 µg/ml
RMB2685.00

Cyclophilin F 抗体 (G-9) Alexa Fluor® 790

sc-376061 AF790
200 µg/ml
RMB2685.00

Cyclophilin F (G-9) 中和勝肽

sc-376061 P
100 µg/0.5 ml
RMB511.00

What application is the blocking peptide sc-376061 P appropriate for?

Asked by: DefinitelyNotMatt
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from Worked goodIt works great without background. The dilution I used was 1:500.
Date published: 2021-10-25
Rated 1 out of 5 by from MW did not correspond in mouse mitochondriaTEsted in mouse purified mitochondria and detected a weak band above 30 KDa, which does not correspond to the expected MW
Date published: 2018-01-17
Rated 5 out of 5 by from The antibody is goodWe applied for the sample.We used cyclophilinF for WB, it worked very well.
Date published: 2017-08-13
Rated 5 out of 5 by from antibody works willI've asked for free samples from santa cruz. This antibody is good for WB.
Date published: 2017-02-23
Rated 5 out of 5 by from This is the oneCyclophilin F Antibody (G-9) is the one to get if you are doing WB or IHCP. Observed strong and specific band across multiple sample and robust staining with paraffin-embedded human tissue
Date published: 2017-01-27
Rated 5 out of 5 by from Great featuresI bought this a month ago,and I so happy that got the result
Date published: 2016-11-04
Rated 5 out of 5 by from Produced excellent immunoperoxidase cytoplasmicProduced excellent immunoperoxidase cytoplasmic and nuclear staining in formalin fixed, paraffin-embedded human lymph node tissue. -SCBT QC
Date published: 2015-04-28
Rated 5 out of 5 by from Satisfactory Western Blot data of CyclophilinSatisfactory Western Blot data of Cyclophilin F expression in Hep G2 and PC-3 whole cell lysates. -SCBT QC
Date published: 2014-04-19
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Cyclophilin F 抗体 (G-9) is rated 4.4 out of 5 by 8.
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