Date published: 2025-9-7

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Cyclophilin 40 抗体 (C-11): sc-137216

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说明书
  • Cyclophilin 40 抗体 C-11 是小鼠单克隆 IgG2b κ,Cyclophilin 40抗体, 在3篇文献中引用,规格为200 µg/ml
  • 针对氨基酸186-370,在Cyclophilin 40的human起源的C-terminus处进行映射
  • Cyclophilin 40 抗体 (C-11) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 Cyclophilin 40
  • 抗Cyclophilin 40抗体(C-11)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Cyclophilin 40 (C-11): sc-137216免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGκ BP-HRP是Cyclophilin 40 Antibody (C-11) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与Cyclophilin 40 Antibody (C-11) 搭配使用(请参阅下面的订购信息)。有关其它 m-IgGκ BP 结合物,请参阅我们完整的小鼠 IgG 结合蛋白列表。

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関連項目

Cyclophilin 40 抗体(C-11)是一种 IgG2b κ 小鼠单克隆 Cyclophilin 40 抗体(也称为 PPID 抗体或 CYP-40 抗体),可通过 WB、IP、IF 和 ELISA 检测小鼠、大鼠和人的 Cyclophilin 40 蛋白。Cyclophilin 40 抗体(C-11)既可以是非偶联的抗 Cyclophilin 40 抗体形式,也可以是多种偶联形式的抗 Cyclophilin 40 抗体,包括琼脂糖、HRP、PE、FITC 和多种 Alexa Fluor® 偶联物。亲环素是保守的、普遍存在的且丰富的胞质肽基脯氨酰顺反异构酶,可加速 XaaPro 肽键的异构化和蛋白质的重新折叠。人亲环素 A(CyPA)是一种由 165 个氨基酸组成的胞内蛋白,是环孢菌素 A(CsA)的靶标,由从酵母到人类都保守的单一独特基因编码。亲环素 B(CyPB)分泌于血液或乳汁等生物体液中,并与人淋巴母细胞系 Jurkat 和人外周血淋巴细胞上存在的特定受体结合。Cyclophilin 40(CyP40)是一种广泛表达的胞质蛋白,可催化寡肽中脯氨酸亚胺基肽键的顺反异构化。它是一种广泛表达的胞质蛋白。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cyclophilin 40 抗体 (C-11) 参考文献:

  1. 通过对分类 N 端肽段进行质谱鉴定,探索蛋白质组并分析蛋白质加工过程。  |  Gevaert, K., et al. 2003. Nat Biotechnol. 21: 566-9. PMID: 12665801
  2. 嗜环蛋白 D:敲开死亡之门。  |  Schneider, MD. 2005. Sci STKE. 2005: pe26. PMID: 15942033
  3. 嗜环蛋白 D 是线粒体通透性转换的一个组成部分,在局灶性脑缺血后介导神经细胞死亡。  |  Schinzel, AC., et al. 2005. Proc Natl Acad Sci U S A. 102: 12005-10. PMID: 16103352
  4. 源自喹喔啉的新型环嗜蛋白酶 D 抑制剂对大鼠线粒体肿胀和 Ca2+ 摄取/释放具有高度抑制活性。  |  Guo, HX., et al. 2005. Acta Pharmacol Sin. 26: 1201-11. PMID: 16174436
  5. 嗜环蛋白40:一种与类固醇受体相关的Hsp90-伴侣蛋白。  |  Ratajczak, T., et al. 2009. Int J Biochem Cell Biol. 41: 1652-5. PMID: 19433306
  6. 环嗜蛋白-40相互作用蛋白的鉴定揭示了环嗜蛋白-40的潜在细胞功能。  |  Park, MS., et al. 2011. Anal Biochem. 410: 257-65. PMID: 21146485
  7. Cyclophilin 40可改变UVA诱导的角质形成细胞凋亡和线粒体ROS生成。  |  Jandova, J., et al. 2013. Exp Cell Res. 319: 750-60. PMID: 23220213
  8. 人类环纤蛋白40能解开神经毒性淀粉样蛋白。  |  Baker, JD., et al. 2017. PLoS Biol. 15: e2001336. PMID: 28654636
  9. 分子动力学模拟环磷脂蛋白40的TPR结构域中的位点突变,确定了具有不同动态和酶特性的构象状态。  |  Gur, M., et al. 2018. J Chem Phys. 148: 145101. PMID: 29655319
  10. 环嗜蛋白-40:与 hsp90 形成二聚体复合物的证据。  |  Hoffmann, K. and Handschumacher, RE. 1995. Biochem J. 307 (Pt 1): 5-8. PMID: 7717993
  11. 与类固醇受体复合物中的 P59 成分具有同源性的蛋白质 Cyclophilin-40。克隆 cDNA 并进一步确定其特征。  |  Kieffer, LJ., et al. 1993. J Biol Chem. 268: 12303-10. PMID: 8509368
  12. 人类环纤蛋白 40(PPID)基因的结构和完整核苷酸序列。  |  Yokoi, H., et al. 1996. Genomics. 35: 448-55. PMID: 8812478

订购信息

产品名称产品编号规格价格数量收藏夹

Cyclophilin 40 抗体 (C-11)

sc-137216
200 µg/ml
RMB2377.00

Cyclophilin 40 (C-11): m-IgGκ BP-HRP 套装

sc-521453
200 µg Ab, 40 µg BP
RMB2662.00

Cyclophilin 40 抗体 (C-11) AC

sc-137216 AC
500 µg/ml, 25% agarose
RMB3129.00

Cyclophilin 40 抗体 (C-11) HRP

sc-137216 HRP
200 µg/ml
RMB2377.00

Cyclophilin 40 抗体 (C-11) FITC

sc-137216 FITC
200 µg/ml
RMB2482.00

Cyclophilin 40 抗体 (C-11) PE

sc-137216 PE
200 µg/ml
RMB2580.00

Cyclophilin 40 抗体 (C-11) Alexa Fluor® 488

sc-137216 AF488
200 µg/ml
RMB2685.00

Cyclophilin 40 抗体 (C-11) Alexa Fluor® 546

sc-137216 AF546
200 µg/ml
RMB2685.00

Cyclophilin 40 抗体 (C-11) Alexa Fluor® 594

sc-137216 AF594
200 µg/ml
RMB2685.00

Cyclophilin 40 抗体 (C-11) Alexa Fluor® 647

sc-137216 AF647
200 µg/ml
RMB2685.00

Cyclophilin 40 抗体 (C-11) Alexa Fluor® 680

sc-137216 AF680
200 µg/ml
RMB2685.00

Cyclophilin 40 抗体 (C-11) Alexa Fluor® 790

sc-137216 AF790
200 µg/ml
RMB2685.00

What is the recommended fixation method for immunofluorescence staining with Cyclophilin 40 (C-11): sc-137216 monoclonal antibody?

Asked by: TinTin
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Lab ManagerI got this a month ago as a sample, It works great on WB, only shows one clean band, no background.
Date published: 2019-09-25
Rated 3 out of 5 by from Not quite strong band1:500 diluted for wb of rat heart protein ,the band is not quite strong,I will try 1:200 diluted again.
Date published: 2017-09-27
Rated 5 out of 5 by from specific staining.This antibody gave a positive staining when use it detect Cyclophilin 40 in mouse lung tissue, I obtained specific staining.
Date published: 2017-05-13
Rated 4 out of 5 by from This has worked well in WBThis has worked well in WB.
Date published: 2015-10-27
Rated 5 out of 5 by from Produced superb immunofluorescence cytoplasmicProduced superb immunofluorescence cytoplasmic staining in methanol-fixed NIH/3T3 cells. -SCBT QC
Date published: 2015-02-14
Rated 5 out of 5 by from Good Western Blot data of Cyclophilin 40Good Western Blot data of Cyclophilin 40 expression in non-transfected 293T, mouse Cyclophilin 40 transfected 293T, JAR and NIH/3T3 whole cell lysates. -SCBT QC
Date published: 2013-05-12
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Cyclophilin 40 抗体 (C-11) is rated 4.5 out of 5 by 6.
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