Date published: 2025-9-7

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cyclin T2a/b 抗体 (2128C1a): sc-81243

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说明书
  • cyclin T2a/b 抗体 2128C1a 是小鼠单克隆 IgG1cyclin T2a/b抗体, 在7篇文献中引用,规格为100 µg/ml
  • 针对与human起源的cyclin T2a/b的内部区域对应的重组蛋白
  • 推荐用于 human 来源的cyclin T2a and cyclin T2b WB 和 IP检测
  • 关于如何获取cyclin T2a/b (2128C1a): sc-81243免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是cyclin T2a/b Antibody (2128C1a) for WB applications. 的首选辅助检测试剂,这些试剂现与cyclin T2a/b Antibody (2128C1a) 打包提供(请参阅下面的订购信息)。

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関連項目

cyclin T2a/b抗体(2128C1a)是一种IgG1小鼠单克隆cyclin T2a/b抗体(也称为cyclin T2抗体或CCNT2抗体),可通过WB和IP检测人的cyclin T2a/b蛋白。cyclin T2a/b抗体(2128C1a)可作为非偶联抗cyclin T2a/b抗体提供。Cyclin T1被鉴定为Cdk9(一种RNA聚合酶II(RNAPII)转录延长因子)的伴侣。Cyclin T1与HIV-1 Tat蛋白的反式激活域相互作用。Tat与cyclin T1的相互作用增强了Tat对病毒TAR RNA茎环结构的亲和力,这表明Tat可以通过与TAR的协同结合来招募cyclin T1/cdk9到RNAPII。人类正转录延长因子b(P-TEFb)由细胞周期依赖性激酶cdk9和cyclin T组成。Cdk9可以以相互排斥的方式与cyclin T1或cyclin T2配对。由于选择性剪接,cyclin T2存在两种形式:T2a和T2b。Tat与TAR的结合被证明是由人类cyclin T1促进的,而不是由cyclins T2a或T2b促进的。Cyclin T2与Cdk9结合,但不与Tat结合,而且cyclin T2可以抑制cyclin T1介导的Tat活性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

cyclin T2a/b 抗体 (2128C1a) 参考文献:

  1. 人类细胞周期蛋白 T1 可促进 Tat 和 TAR 之间的相互作用以及人类免疫缺陷病毒的复制,但细胞周期蛋白 T2a 或 T2b 却不能。  |  Wimmer, J., et al. 1999. Virology. 255: 182-9. PMID: 10049833
  2. 与 CDK9 相关的细胞周期蛋白 T1 和 T2 对 HIV-1 Tat 的活性具有相反的作用。  |  Napolitano, G., et al. 1999. AIDS. 13: 1453-9. PMID: 10465067
  3. Cyclin T2a 基因位于人类染色体 2q21 上。  |  De Luca, A., et al. 2001. J Histochem Cytochem. 49: 693-8. PMID: 11373316
  4. 在 PAMP 激活的单核细胞衍生物巨噬细胞中,细胞周期蛋白 T1 而非细胞周期蛋白 T2a 是通过转录后机制诱导的。  |  Liou, LY., et al. 2006. J Leukoc Biol. 79: 388-96. PMID: 16330531
  5. Pkn 是细胞周期蛋白 T2a 在肌肉分化过程中的新伙伴。  |  Cottone, G., et al. 2006. J Cell Physiol. 207: 232-7. PMID: 16331689
  6. 细胞周期蛋白依赖性激酶 9 相关途径在哺乳动物基因表达和人类疾病中的作用。  |  Romano, G. and Giordano, A. 2008. Cell Cycle. 7: 3664-8. PMID: 19029809
  7. 7SK RNA 在调控基因表达中的核组织和动态。  |  Prasanth, KV., et al. 2010. Mol Biol Cell. 21: 4184-96. PMID: 20881057
  8. 小鼠细胞周期蛋白 T2A 和细胞周期蛋白 T2B 在骨骼肌分化过程中的激活和功能  |  Marchesi, I., et al. 2013. J Cell Biochem. 114: 728-34. PMID: 23060074
  9. 慢病毒 Tat 蛋白与细胞蛋白激酶 TAK 特异性结合,TAK 可使 RNA 聚合酶 II 大亚基的羧基末端结构域过度磷酸化:Tat 辅因子的候选者。  |  Herrmann, CH. and Rice, AP. 1995. J Virol. 69: 1612-20. PMID: 7853496
  10. TAK是一种与HIV Tat相关的激酶,属于细胞周期蛋白依赖性蛋白激酶家族的成员,外周血淋巴细胞的活化和原核细胞系的分化都会诱导TAK。  |  Yang, X., et al. 1997. Proc Natl Acad Sci U S A. 94: 12331-6. PMID: 9356449
  11. 一种新型 CDK9 相关 C 型细胞周期蛋白与 HIV-1 Tat 直接相互作用,并介导其与 TAR RNA 的高亲和力, 环特异性结合。  |  Wei, P., et al. 1998. Cell. 92: 451-62. PMID: 9491887
  12. 鉴定人类 P-TEFb 的多个细胞周期蛋白亚基。  |  Peng, J., et al. 1998. Genes Dev. 12: 755-62. PMID: 9499409

订购信息

产品名称产品编号规格价格数量收藏夹

cyclin T2a/b 抗体 (2128C1a)

sc-81243
100 µg/ml
RMB2504.00

cyclin T2a/b (2128C1a): m-IgG Fc BP-HRP 套装

sc-539603
100 µg Ab; 10 µg BP
RMB2662.00

cyclin T2a/b (2128C1a): m-IgG1 BP-HRP 套装

sc-541591
100 µg Ab; 20 µg BP
RMB2662.00

Is it known what internal part of CCNT2 protein is targeted with this antibody? 

Asked by: Tjhafe
Thank you for your question. It would be helpful if you could call 800-457-3801, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Service
Date published: 2022-12-09

I am using cyclin T2a/b (2128C1a): sc-81243 antibody for immunoprecipitation, how much antibody should I use?

Asked by: Cweed
Thank you for your question. We recommend using 1–10 µl (i.e., 0.2–2 µg) of antibody with 1 ml of cell lysate. However, optimal antibody concentration should be determined by titration. Please find our full immunoprecipitation protocol here: https://www.scbt.com/scbt/resources/protocols/immunoprecipitation-western-blots
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from Good for Western BlotThis antibody works in human cell lines HeLa, IMR-32, and HepG2. -SCBT QC
Date published: 2023-09-14
Rated 5 out of 5 by from good productClean double band appearing at ~100 & ~80 kDa in HeLa whole cell lysate.
Date published: 2018-04-26
Rated 4 out of 5 by from a good antibody for WBThis antibody generates a clear signal at the predicted position on the WB (1:500 dilution, 40ug HeLa extract), albeit with a higher background
Date published: 2017-09-18
Rated 4 out of 5 by from good antibodyit is a good antibody for western blot analysis when I tested it in lung cancer cell lines.
Date published: 2017-08-29
Rated 4 out of 5 by from Band at expected size but faintBand at expected size but faint. WB data in NIH/3T3. -SCBT QC
Date published: 2013-07-08
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cyclin T2a/b抗体 (2128C1a) is rated 4.4 out of 5 by 5.
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