Date published: 2025-9-8

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CTMP 抗体 (H-10): sc-390353

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说明书
  • CTMP 抗体 H-10 是小鼠单克隆 IgG1 κ,CTMP抗体, 在2篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列1-137位于human物种的CTMP的N-terminus
  • CTMP 抗体 (H-10) 推荐用于WB, IP, IF, IHC(P) 和 ELISA,检测human 来源的 CTMP
  • 抗CTMP抗体(H-10)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取CTMP (H-10): sc-390353免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgGκ BP-HRP 是 CTMP 抗体 (H-10) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与CTMP 抗体 (H-10) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

CTMP抗体(H-10)是一种IgG1κ型小鼠单克隆CTMP抗体(也称为CTMP抗体),可通过WB、IP、IF、IHC(P)和ELISA等方法检测人源的CTMP蛋白。CTMP抗体(H-10)既有非共轭形式的抗CTMP抗体,也有多种共轭形式的抗CTMP抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®共轭物。Akt蛋白激酶家族(也称为PKB)在胰岛素信号转导、细胞存活和转化中发挥作用。导致磷酸肌醇-3-激酶(PI3K)/Akt信号通路异常激活的遗传改变常发生于胶质母细胞瘤中。这些因素包括磷酸酶和张力蛋白同源物(PTEN)突变、表皮生长因子受体(EGFR)扩增和重排,以及羧基末端调节蛋白(CTMP)超甲基化。CTMP与Akt的C末端调节域结合并起负调节作用。CTMP抑制Akt在丝氨酸473和苏氨酸308上的磷酸化,从而降低其活性。CTMP启动子的超甲基化导致其表达减少,这与胶质母细胞瘤的发病有关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CTMP 抗体 (H-10) 参考文献:

  1. 羧基末端调节蛋白(CTMP)是质膜上 PKB/Akt 和 v-Akt 的负调节因子。  |  Maira, SM., et al. 2001. Science. 294: 374-80. PMID: 11598301
  2. 胶质母细胞瘤中羧基末端调节蛋白基因的高甲基化和转录下调。  |  Knobbe, CB., et al. 2004. J Natl Cancer Inst. 96: 483-6. PMID: 15026474
  3. 生长因子诱导的发育中副交感神经元功能性 K(Ca)通道的迁移需要 Akt 激活。  |  Chae, KS., et al. 2005. J Neurophysiol. 93: 1174-82. PMID: 15509648
  4. 人类胶质母细胞瘤中磷酸肌醇-3-激酶/Akt通路基因PIK3CA和PIKE的基因改变和表达。  |  Knobbe, CB., et al. 2005. Neuropathol Appl Neurobiol. 31: 486-90. PMID: 16150119
  5. 核内 3'-磷酸肌醇代谢和 Akt 信号:肿瘤发生和防止细胞凋亡的新机制?  |  Martelli, AM., et al. 2006. Cell Signal. 18: 1101-7. PMID: 16516442
  6. 调节磷酸肌酸 3- 激酶信号通路可改变宿主对败血症, 炎症和缺血/再灌注损伤的反应。  |  Williams, DL., et al. 2006. Shock. 25: 432-9. PMID: 16680006
  7. cCMP、cUMP、cTMP、cIMP和cXMP作为可能的第二信使:根据可溶性鸟苷酸环化酶α(1)β(1)的研究提出假设。  |  Beste, KY. and Seifert, R. 2013. Biol Chem. 394: 261-70. PMID: 23087103
  8. 基于CTMP的纤维素纤维用核壳乳胶改性,用于增强生物复合材料。  |  Pan, Y., et al. 2013. Carbohydr Polym. 95: 428-33. PMID: 23618289
  9. CTMP,一种预测HER2富集乳腺癌患者对曲妥珠单抗耐药性的生物标志物。  |  Chen, YC., et al. 2017. Oncotarget. 8: 29699-29710. PMID: 27447863
  10. 镍硼酸盐和环三磷酸(CTMP)的非生物合成核苷5'-三磷酸。  |  Kim, HJ. and Benner, SA. 2021. Astrobiology. 21: 298-306. PMID: 33533695
  11. 线粒体蛋白LETM1及其介导的CTMP是子宫内膜癌的潜在治疗靶点。  |  Niu, F., et al. 2022. Anticancer Drugs. 33: 632-641. PMID: 35324530
  12. 用于纸电池电极的CTMP中木质素的电化学特性。  |  Isacsson, P., et al. 2024. ChemSusChem. 17: e202400222. PMID: 38874273

订购信息

产品名称产品编号规格价格数量收藏夹

CTMP 抗体 (H-10)

sc-390353
200 µg/ml
RMB2377.00

CTMP (H-10): m-IgG Fc BP-HRP 套装

sc-530134
200 µg Ab; 10 µg BP
RMB2662.00

CTMP (H-10): m-IgGκ BP-HRP 套装

sc-523505
200 µg Ab, 40 µg BP
RMB2662.00

CTMP 抗体 (H-10) AC

sc-390353 AC
500 µg/ml, 25% agarose
RMB3129.00

CTMP 抗体 (H-10) HRP

sc-390353 HRP
200 µg/ml
RMB2377.00

CTMP 抗体 (H-10) FITC

sc-390353 FITC
200 µg/ml
RMB2482.00

CTMP 抗体 (H-10) PE

sc-390353 PE
200 µg/ml
RMB2580.00

CTMP 抗体 (H-10) Alexa Fluor® 488

sc-390353 AF488
200 µg/ml
RMB2685.00

CTMP 抗体 (H-10) Alexa Fluor® 546

sc-390353 AF546
200 µg/ml
RMB2685.00

CTMP 抗体 (H-10) Alexa Fluor® 594

sc-390353 AF594
200 µg/ml
RMB2685.00

CTMP 抗体 (H-10) Alexa Fluor® 647

sc-390353 AF647
200 µg/ml
RMB2685.00

CTMP 抗体 (H-10) Alexa Fluor® 680

sc-390353 AF680
200 µg/ml
RMB2685.00

CTMP 抗体 (H-10) Alexa Fluor® 790

sc-390353 AF790
200 µg/ml
RMB2685.00

which product of CTMP antibodies can be used for flow cytometric when the sample is formalin-fixed-paraffin-embedded tissue sections and what is the protocol please?

Asked by: makhoul
Thank you for your question. Please contact our Technical Service Department for help in determining which is the best antibody for your intended research applications. We would not recommend using formalin-fixed paraffin-embedded tissue sections for any flow cytometry application.
Answered by: Technical Support
Date published: 2019-02-27

Can CTMP (H-10): sc-390353 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Professor Griffin
Thank you for your question. Yes, CTMP (H-10): sc-390353 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by from Exceptional immunoperoxidase cytoplasmicExceptional immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human pancreas tissue. -SCBT QC
Date published: 2015-04-29
Rated 5 out of 5 by from Nice Western Blot data of CTMP expressionNice Western Blot data of CTMP expression in human skeletal muscle tissue extract. -SCBT QC
Date published: 2013-11-18
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CTMP抗体 (H-10) is rated 5.0 out of 5 by 2.
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