Date published: 2025-9-7

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CtIP 抗体 (F-2): sc-28324

5.0(2)
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说明书
  • CtIP抗体(F-2)是小鼠单克隆IgG2a κ, 在1篇文献中引用,规格为200 µg/ml
  • 免疫human物种的CtIP的氨基酸598-897
  • 推荐用于 mouse, rat 和 human 来源的CtIP WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRPm-IgGκ BP-HRP是CtIP Antibody (F-2) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与CtIP Antibody (F-2) 打包提供(请参阅下面的订购信息)。

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関連項目

CtBP1是一种细胞磷酸蛋白,可与多种蛋白质相互作用,并充当转录抑制因子。CtBP1和相关蛋白CtBP2是腺病毒E1A的c端结合蛋白,它们优先通过一个5个氨基酸基序PLDLS与E1A结合,从而抑制E1A诱导的肿瘤发生和细胞转化。CtBP1从胚胎到成人都有表达,而CtBP2主要在胚胎发育期表达。在骨骼和T细胞发育期,CtBP1和CtBP2与dEF1的PLDLSL结构域结合,dEF1是一种细胞锌指-家族蛋白,从而增强dEF1诱导的转录抑制。此外,CtBP与CtIP结合,CtIP是一种与CtBP不同的蛋白质基序识别蛋白。CtIP与乳腺癌基因BRCA1的BRCT重复结合,使CtBP能够影响BRCA1活性。CtIP/CtBP与BRCA1的结合抑制p21启动子的转录激活,对于调节DNA损伤反应中p21转录起着关键作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CtIP 抗体 (F-2) 参考文献:

  1. DNA末端切除和修复需要CtIP四聚物组装。  |  Davies, OR., et al. 2015. Nat Struct Mol Biol. 22: 150-157. PMID: 25558984
  2. CtIP/Ctp1/Sae2,分子形式与功能相匹配。  |  Andres, SN. and Williams, RS. 2017. DNA Repair (Amst). 56: 109-117. PMID: 28623092
  3. CtIP 对端粒复制至关重要。  |  Stroik, S., et al. 2019. Nucleic Acids Res. 47: 8927-8940. PMID: 31378812
  4. CtIP 的内部区域对 DNA 末端切除起负向调节作用。  |  Howard, SM., et al. 2020. Nucleic Acids Res. 48: 5485-5498. PMID: 32347940
  5. 微肽 PACMP 抑制剂通过减少 CtIP 和聚(ADP-核糖基)的生成而产生合成致死效应。  |  Zhang, C., et al. 2022. Mol Cell. 82: 1297-1312.e8. PMID: 35219381
  6. PLK1 介导的 PPIL2 磷酸化通过 CtIP 调节 HR。  |  Qiu, Z., et al. 2022. Front Cell Dev Biol. 10: 902403. PMID: 36092721
  7. CtIP通过调节TPX2-极光A信号轴调控有丝分裂纺锤体的组装  |  Oh, W., et al. 2022. Cells. 11: PMID: 36139389
  8. 在没有 BRCA2/RAD51 的情况下,POLθ 通过填补滞后链间隙防止 MRE11-NBS1-CtIP 依赖性断叉。  |  Mann, A., et al. 2022. Mol Cell. 82: 4218-4231.e8. PMID: 36400008
  9. PLK1调节CtIP和DNA2在长距离DNA末端切除中的相互作用。  |  Ceppi, I., et al. 2023. Genes Dev. 37: 119-135. PMID: 36746606
  10. NUDT16调节CtIP的PAR化作用,从而决定同源重组修复。  |  Zhang, Z., et al. 2024. Nucleic Acids Res. 52: 3761-3777. PMID: 38324469

订购信息

产品名称产品编号规格价格数量收藏夹

CtIP 抗体 (F-2)

sc-28324
200 µg/ml
RMB2377.00

CtIP (F-2): m-IgG Fc BP-HRP 套装

sc-536712
200 µg Ab; 10 µg BP
RMB2662.00

CtIP (F-2): m-IgGκ BP-HRP 套装

sc-533872
200 µg Ab; 40 µg BP
RMB2662.00

CtIP (F-2): m-IgG2a BP-HRP 套装

sc-547855
200 µg Ab; 10 µg BP
RMB2662.00

Are there any issues with using sc-28324: CtIP (F-2) mouse monoclonal primary antibody on mouse samples?

Asked by: Cweed
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-28324 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by from Nice Western Blot data of CtIP expression in nonNice Western Blot data of CtIP expression in non-transfected 293T, mouse CtIP transfected 293T and Jurkat whole cell lysates. -SCBT QC
Date published: 2015-03-13
Rated 5 out of 5 by from Produced positive Western Blot data of CtIPProduced positive Western Blot data of CtIP expression in T24 whole cell lysate and Jurkat nuclear extract . -SCBT QC
Date published: 2013-10-26
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CtIP 抗体 (F-2) is rated 5.0 out of 5 by 2.
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