Date published: 2025-9-7

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CtIP 抗体 (E-2): sc-48415

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说明书
  • CtIP抗体(E-2)是小鼠单克隆IgG1 κ, 在3篇文献中引用,规格为200 µg/ml
  • 免疫human物种的CtIP的氨基酸598-897
  • 推荐用于 mouse, rat 和 human 来源的CtIP WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRPm-IgGκ BP-HRP是CtIP Antibody (E-2) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与CtIP Antibody (E-2) 打包提供(请参阅下面的订购信息)。

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関連項目

CtBP1是一种细胞磷酸蛋白,可与多种蛋白质相互作用,并充当转录抑制因子。CtBP1和相关蛋白CtBP2被认为是腺病毒E1A的C末端特异性结合蛋白,它们通过一个五氨基酸基序PLDLS优先与E1A结合,以抑制E1A诱导的致癌和细胞转化。CtBP1从胚胎到成人都有表达,而CtBP2主要在胚胎发育期表达。在骨骼和T细胞发育期,CtBP1和CtBP2与dEF1的PLDLSL结构域结合,dEF1是一种细胞锌指-家族蛋白,从而增强dEF1诱导的转录抑制。此外,CtBP与CtIP结合,CtIP是一种与CtBP不同的蛋白质基序识别蛋白。CtIP与乳腺癌基因BRCA1的BRCT重复结合,使CtBP能够影响BRCA1活性。CtIP/CtBP与BRCA1的结合抑制p21启动子的转录激活,对于调节DNA损伤反应中p21转录起着关键作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CtIP 抗体 (E-2) 参考文献:

  1. Ctp1/CtIP和MRN复合体在同源重组的初始阶段进行协作。  |  Takeda, S., et al. 2007. Mol Cell. 28: 351-2. PMID: 17996697
  2. DNA损伤与决策:CtIP协调DNA修复和细胞周期检查点。  |  You, Z. and Bailis, JM. 2010. Trends Cell Biol. 20: 402-9. PMID: 20444606
  3. CtIP介导的切除对于存活至关重要,且可独立于BRCA1发挥作用。  |  Polato, F., et al. 2014. J Exp Med. 211: 1027-36. PMID: 24842372
  4. BRCA1加速CtIP介导的DNA末端切除。  |  Cruz-García, A., et al. 2014. Cell Rep. 9: 451-9. PMID: 25310973
  5. 乙型肝炎病毒感染抑制肝癌细胞中 CtIP 的表达  |  Zhang, D., et al. 2018. J Cancer. 9: 1182-1187. PMID: 29675099
  6. CTCF 与 CtIP 合作,驱动双链断裂的同源重组修复。  |  Hwang, SY., et al. 2019. Nucleic Acids Res. 47: 9160-9179. PMID: 31340001
  7. ATM通过诱导CtIP的翻译后修饰来控制DNA末端切除的程度。  |  Han, J., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 33723063
  8. 在异种移植小鼠模型中,CtIP抑制原发性microRNA成熟并促进结肠癌细胞的转移。  |  Ren, J., et al. 2021. J Biol Chem. 296: 100707. PMID: 33901493
  9. NBS1-CtIP介导的DNA末端切除抑制cGAS与微核的结合。  |  Abdisalaam, S., et al. 2022. Nucleic Acids Res. 50: 2681-2699. PMID: 35189637
  10. CtIP负责调控小鼠卵母细胞减数分裂过程中的G2/M期转换和双极纺锤体组装。  |  Yue, W., et al. 2024. J Genet Genomics. 51: 1435-1446. PMID: 39277031

订购信息

产品名称产品编号规格价格数量收藏夹

CtIP 抗体 (E-2)

sc-48415
200 µg/ml
RMB2377.00

CtIP (E-2): m-IgG Fc BP-HRP 套装

sc-536836
200 µg Ab; 10 µg BP
RMB2662.00

CtIP (E-2): m-IgGκ BP-HRP 套装

sc-534003
200 µg Ab; 40 µg BP
RMB2662.00

CtIP (E-2): m-IgG2a BP-HRP 套装

sc-547880
200 µg Ab; 10 µg BP
RMB2662.00

I need to use an antibody to detect the protein in samples of equine origin. Do you know if sc-48415: CtIP (E-2) mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support
Date published: 2017-03-06
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Rated 5 out of 5 by from Good productThe CtIP Antibody (E-2): sc-48415 works well for a variety of applications, including WB, IP, IF, and ELISA.
Date published: 2017-02-03
Rated 5 out of 5 by from Performs well in WesternPerforms well in Western, good signal with mouse CtIP transfected 293T and Jurkat whole cell lysates. -SCBT QC
Date published: 2015-05-09
Rated 5 out of 5 by from Band detected at expected mw in T24 wholeBand detected at expected mw in T24 whole cell lysate and Jurkat nuclear extract. -SCBT QC
Date published: 2015-02-13
Rated 5 out of 5 by from WB publishable data with rabbit sampleWB publishable data with rabbit sample - SCBT Publication Review
Date published: 2013-08-02
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CtIP 抗体 (E-2) is rated 5.0 out of 5 by 4.
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