Date published: 2026-10-24

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CtBP 抗体 (B-3): sc-55502

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说明书
  • CtBP抗体(B-3)是小鼠单克隆IgG2a κ, 在9篇文献中引用,规格为200 µg/ml
  • 免疫human物种的CtBP1的氨基酸1-440
  • 推荐用于 mouse, rat 和 human 来源的CtBP1 and CtBP2 WB, IP, IF 和 ELISA检测
  • 看 CtBP (E-12): sc-17759,可查看有标记的 CtBP 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP、 2a BP-HRP">m-IgG2a BP-HRP和m-IgGκ BP-HRP是CtBP Antibody (B-3) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与CtBP Antibody (B-3) 打包提供(请参阅下面的订购信息)。
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CtBP 抗体 (B-3) 是一种小鼠单克隆 IgG2a 抗体,可通过免疫印迹 (WB)、免疫沉淀 (IP)、免疫荧光 (IF) 和酶联免疫吸附 (ELISA) 等应用检测小鼠、大鼠和人样本中的 CtBP。抗 CtBP 抗体(B-3)对研究细胞发育和分化尤为重要,因为 CtBP 与一系列转录因子相互作用抑制靶基因。值得注意的是,CtBP 参与了 p21 启动子对 DNA 损伤的调控,这一关键功能有助于维持基因组的稳定性。CtBP 与 CtIP(一种能识别不同图案的蛋白质)之间的相互作用对这一调控机制至关重要,因为 CtIP 能与乳腺癌基因 BRCA1 的 BRCT 重复序列结合,从而使 CtBP 能够影响 BRCA1 的活性。CtBP 与其他蛋白(如 δEF1)形成复合物的能力进一步强调了它在骨骼和 T 细胞发育过程中转录沉默的重要性。CtBP 单克隆抗体 (B-3) 用途广泛,在细胞调控中发挥着重要作用,是研究基因表达及其在各种生物过程中的影响的研究人员的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CtBP 抗体 (B-3) 参考文献:

  1. 由CtBP共抑制复合物介导的协调组蛋白修饰。  |  Shi, Y., et al. 2003. Nature. 422: 735-8. PMID: 12700765
  2. 共抑制剂CtBP和核斑蛋白Pnn/DRS可分别调节E-钙黏蛋白基因的转录和剪接。  |  Alpatov, R., et al. 2008. Mol Cell Biol. 28: 1584-95. PMID: 18086895
  3. CtBP的寡聚状态决定了其作为转录共激活因子和Wingless靶标共抑制剂的作用。  |  Bhambhani, C., et al. 2011. EMBO J. 30: 2031-43. PMID: 21468031
  4. CtBP的全基因组图谱将代谢与乳腺癌中的基因组稳定性和上皮细胞重编程联系起来。  |  Di, LJ., et al. 2013. Nat Commun. 4: 1449. PMID: 23385593
  5. CtBP通过调节SIRT4维持癌细胞的生长和代谢平衡。  |  Wang, L., et al. 2015. Cell Death Dis. 6: e1620. PMID: 25633289
  6. 以结构为导向设计出一种高亲和力的人CtBP抑制剂。  |  Hilbert, BJ., et al. 2015. ACS Chem Biol. 10: 1118-27. PMID: 25636004
  7. 人类C端结合蛋白(CtBP)组装成四聚体。  |  Bellesis, AG., et al. 2018. J Biol Chem. 293: 9101-9112. PMID: 29700119
  8. CtBP-a是胰腺腺癌中肿瘤启动细胞活性和转移的靶向依赖性。  |  Chawla, AT., et al. 2019. Oncogenesis. 8: 55. PMID: 31586042
  9. CtBP 通过抑制死亡受体决定卵巢癌细胞的命运。  |  Ding, B., et al. 2020. Cell Death Dis. 11: 286. PMID: 32332713
  10. CtBP 蛋白可转录基质金属蛋白酶和促炎细胞因子,从而介导腹主动脉瘤的发病机制。  |  Bai, L., et al. 2022. Exp Cell Res. 421: 113386. PMID: 36244410

订购信息

产品名称产品编号规格价格数量收藏夹

CtBP 抗体 (B-3)

sc-55502
200 µg/ml
CNY2422.00

CtBP (B-3): m-IgG Fc BP-HRP 套装

sc-537055
200 µg Ab; 10 µg BP
CNY2715.00

CtBP (B-3): m-IgGκ BP-HRP 套装

sc-534240
200 µg Ab; 40 µg BP
CNY2715.00

CtBP (B-3): m-IgG2a BP-HRP 套装

sc-547925
200 µg Ab; 10 µg BP
CNY2715.00

What Residues are the target of this Antibody? Some CtBP antibody make double band with transfected cells but some doesn't. Maybe CtBP has unidentified cleavage site. So I want to check the targeting residue of CtBP antibody.

Asked by: JJaro
Thanks for your question. CtBP Antibody (B-3): sc-55502 is raised against amino acids 1-440 of CtBP1 of human origin. 질문해 주셔서 감사합니다.CtBP 항체 (B-3): sc-55502는 인간 유래 CtBP1의 아미노산 1-440에 의해 생성됩니다.
Answered by: Yanru Tao
Date published: 2025-04-15

What is the recommended fixation method for immunofluorescence staining with CtBP (B-3): sc-55502 monoclonal antibody?

Asked by: Cweed
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by ET from Robust signal in WB with human CtBP1 transfectedRobust signal in WB with human CtBP1 transfected 293T whole cell lysates and HeLa nuclear extract. -SCBT QC
Date published: 2015-05-16
Rated 5 out of 5 by LF from Clean bands observed in western blot analysisClean bands observed in western blot analysis of CtBP expression in HL-60 and KNRK whole cell lysates and NIH/3T3 nuclear extract. -SCBT QC
Date published: 2015-05-06
Rated 5 out of 5 by LM from Produced superb immunofluorescence nuclearProduced superb immunofluorescence nuclear staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-04-30
Rated 5 out of 5 by FL from Clean bands in mouse CtBP1 transfected 293TClean bands in mouse CtBP1 transfected 293T and HeLa whole cell lysates. -SCBT QC
Date published: 2015-01-21
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CtBP 抗体 (B-3) is rated 5.0 out of 5 by 4.
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