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CRMP-4 Antibody (LL-5) - Western Blotting - Image 66276
CRMP-4 抗体 (LL-5): sc-100323. Jurkat 全细胞裂解液中 CRMP-4 表达的 Western 印迹分析.
CRMP-4 抗体 (LL-5): sc-100323. Jurkat 全细胞裂解液中 CRMP-4 表达的 Western 印迹分析.

CRMP-4 抗体 (LL-5): sc-100323

4.2(5)
寫評論提問

说明书
  • CRMP-4 抗体 LL-5 是小鼠单克隆 IgG2a κ，CRMP-4抗体, 在3篇文献中引用，规格为100 µg/ml
  • 免疫human物种的重组CRMP-4
  • 推荐用于 mouse, rat 和 human 来源的CRMP-4 WB, IP 和 ELISA检测
  • 关于如何获取CRMP-4 (LL-5): sc-100323的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成CRMP-4 抗体 (LL-5)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 CRMP 抗体 包括 CRMP-1, CRMP-2, CRMP-4和CRMP-5

CRMP-4抗体（LL-5）是一种IgG2a κ小鼠单克隆CRMP-4抗体（也称为CRMP-4抗体），可通过WB、IP和ELISA检测小鼠、大鼠和人源的CRMP-4蛋白。CRMP-4抗体（LL-5）可作为非偶联抗CRMP-4抗体使用。崩解素反应介导蛋白（CRMPs），包括CRMP-1（DRP-1）、CRMP-2（DRP-2或TOAD64）、CRMP-3（DRP-4）、CRMP-4（DRP-3）和CRMP-5（DRP-5），在神经细胞暴露于轴突导向分子semaphorin 3A（SEMA3A）/崩解素后进行信号转导。CRMPs存在于发育中的大脑皮层和新皮层神经元中，并对SEMA3A有反应。在成年大脑中，CRMPs的表达被显著下调。然而，它们仍然在保持分化和可塑性能力的结构中表达。哺乳动物成年海马中发育的神经元，即齿状回，表达CRMP-4。啮齿动物新皮层神经元在核周体、神经突起和生长锥中表达CRMP-4。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CRMP-4 抗体 (LL-5) 参考文献:

  1. 未成熟神经元标志物 PSA-NCAM, CRMP-4 和 NeuroD 在年轻成年啮齿动物和老年啮齿动物海马中的表达模式。  |  Seki, T. 2002. J Neurosci Res. 70: 327-34. PMID: 12391592
  2. Podarcis hispanica 成体大脑皮层和其他端脑区的 CRMP-4 表达。  |  Nacher, J., et al. 2002. Brain Res Dev Brain Res. 139: 285-94. PMID: 12480143
  3. 塌缩素反应介质蛋白在脂质筏中的亚细胞定位。  |  Rosslenbroich, V., et al. 2003. Biochem Biophys Res Commun. 305: 392-9. PMID: 12745088
  4. 瞬时脑缺血后成年大鼠纹状体中 CRMP-4 的诱导作用  |  Liu, PC., et al. 2003. Acta Pharmacol Sin. 24: 1205-11. PMID: 14653945
  5. 神经营养素诱导背根神经节神经元的神经元延伸过程中，塌缩素反应介导蛋白的参与。  |  Quach, TT., et al. 2004. Mol Cell Neurosci. 25: 433-43. PMID: 15033171
  6. 小鼠精子发生过程中减数分裂后二氢嘧啶酶相关蛋白 3 (DRP-3) 基因的表达。  |  Kato, Y., et al. 1998. Mol Reprod Dev. 51: 105-11. PMID: 9712324

订购信息

产品名称产品编号规格价格数量收藏夹

CRMP-4 抗体 (LL-5)

sc-100323
100 µg/ml
RMB2504.00

This antibody has worked well for us for Western Blot. I now want to test CRMP4 levels by immunofluorescence in mouse brain slices. This antibody is only recommended for WB, is there any chance it would work for IF? Or would that be a waste of time?

Asked by: OCC1
Thank you for your question. We have not yet tested this antibody for IF or IHC in tissues or cells, and so this is not a recommended application at this time. However, it certainly may be worth trying since you already have the antibody. The two citations we are aware of currently are using the antibody in Western blot and IP/WB.
Answered by: Technical Support
Date published: 2019-02-25

我想咨询这一款抗体（编号sc-100323）具体识别CRMP4蛋白（共计570个氨基酸）哪一段序列？谢谢！

Asked by: Chutian
感谢您的提问。CRMP-4 Antibody (LL-5): sc-100323免疫原是人源重组CRMP-4，我们没有检测过其具体识别哪一段序列。Thank you for your question. CRMP-4 Antibody (LL-5): sc-100323 is raised against recombinant CRMP-4 of human origin, we do not know which specific sequences this antibody would recognize.
Answered by: Technical Support 8
Date published: 2018-12-21

For Western Blot, is it recommended to use denatured or non-denatured conditions with CRMP-4 (LL-5): sc-100323 antibody?

Asked by: TinTin
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by from Good specificityGave a single specific band for endogenous U2OS cell lysate and no band when knocked down using RNAi as expected.
Date published: 2018-03-08
Rated 4 out of 5 by from Strong band in WB in mouse transfected 293T and SKStrong band in WB in mouse transfected 293T and SK-N-MC whole cell lysates. -SCBT QC
Date published: 2015-05-11
Rated 4 out of 5 by from Positive signal in WB in Jurkat whole cell lysatePositive signal in WB in Jurkat whole cell lysate. -SCBT QC
Date published: 2015-04-19
Rated 4 out of 5 by from Good specificity in WB in human transfectedGood specificity in WB in human transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-01-29
Rated 4 out of 5 by from Robust signal in WB in human transfectedRobust signal in WB in human transfected 293T whole cell lysates and rat brain tissue extract. -SCBT QC
Date published: 2014-02-25
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CRMP-4 抗体 (LL-5) is rated 4.2 out of 5 by 5.
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