Date published: 2025-9-7

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CPEB 抗体 (G-6): sc-514688

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说明书
  • CPEB 抗体 G-6 是小鼠单克隆 IgG3 κ,CPEB抗体, 在1篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的CPEB的N-terminus附近的氨基酸162-187之间
  • 推荐用于 mouse, rat 和 human 来源的CPEB long and short isoforms WB, IP, IF 和 ELISA检测
  • 可用于ChIP的TransCruz试剂(sc-514688 X, 200 µg/0.1 ml)
  • 关于如何获取CPEB (G-6): sc-514688免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG3 BP-HRP是CPEB Antibody (G-6) 适用于 WB 应用。 的首选辅助检测试剂,该试剂现与CPEB Antibody (G-6) 搭配使用(请参阅下面的订购信息)。

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関連項目

CPEB抗体(G-6)是一种小鼠单克隆IgG3 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类来源的CPEB蛋白。抗CPEB抗体(G-6)可作为非结合单克隆同种型抗体使用。CPEB (G-6) 抗体可识别一种高度保守的RNA结合蛋白,该蛋白与细胞质多聚腺苷酸化元件结合,影响翻译抑制和mRNA定位。CPEB在调节信使RNA翻译方面发挥着关键作用,对细胞周期进展和早期发育计划建立等各种细胞过程至关重要。这种调节在卵母细胞成熟过程中尤为重要,因为卵母细胞成熟过程中mRNA的激活和抑制受到严格控制。CPEB在卵子发生过程中合成并累积在卵母细胞中,通过蛋白酶体途径降解,可能涉及泛素结合的中间体。了解CPEB的功能和调节机制对于阐明基因表达和发育生物学的复杂性至关重要,这使得CPEB(G-6)单克隆抗体成为有价值的研究工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CPEB 抗体 (G-6) 参考文献:

  1. Maskin 是一种与 CPEB 相关的因子,能与 elF-4E 发生瞬时相互作用。  |  Stebbins-Boaz, B., et al. 1999. Mol Cell. 4: 1017-27. PMID: 10635326
  2. CPEB 蛋白控制着秀丽隐杆线虫精子发生的两个关键步骤。  |  Luitjens, C., et al. 2000. Genes Dev. 14: 2596-609. PMID: 11040214
  3. 有丝分裂装置上的 CPEB, maskin 和 cyclin B1 mRNA:对细胞分裂的局部翻译控制的影响。  |  Groisman, I., et al. 2000. Cell. 103: 435-47. PMID: 11081630
  4. 人类细胞质多腺苷酸化酶结合蛋白基因的鉴定和特征描述。  |  Welk, JF., et al. 2001. Gene. 263: 113-20. PMID: 11223249
  5. CPEB 的转化控制:达到目的的手段。  |  Mendez, R. and Richter, JD. 2001. Nat Rev Mol Cell Biol. 2: 521-9. PMID: 11433366
  6. cdc2激酶磷酸化和保守的N端蛋白水解基团在细胞质多腺苷酸-元素结合蛋白(CPEB)复合物解离和降解中的作用  |  Thom, G., et al. 2003. Biochem J. 370: 91-100. PMID: 12401129
  7. 细胞质多腺苷酸化酶结合蛋白依赖的蛋白质合成受钙/钙调蛋白依赖性蛋白激酶 II 的调控。  |  Atkins, CM., et al. 2004. J Neurosci. 24: 5193-201. PMID: 15175389
  8. RINGO/cdk1和CPEB介导ePAB的poly(A)尾稳定和翻译调控。  |  Kim, JH. and Richter, JD. 2007. Genes Dev. 21: 2571-9. PMID: 17938241
  9. CPEB 对人体细胞衰老, 能量代谢和 p53 mRNA 翻译的调控。  |  Burns, DM. and Richter, JD. 2008. Genes Dev. 22: 3449-60. PMID: 19141477
  10. 爪蟾CPEB能在感觉神经元中形成朊病毒样多聚体,从而促进长期的促进作用  |  Si, K., et al. 2010. Cell. 140: 421-35. PMID: 20144764
  11. 抗增殖蛋白Tob通过细胞质多腺苷酸化酶结合蛋白CPEB直接调节c-myc原癌基因的表达。  |  Ogami, K., et al. 2014. Oncogene. 33: 55-64. PMID: 23178487
  12. 通过删除过氧化氢酶基因cpeB来降低苹果果实中黑曲霉的毒性。  |  Zhang, MK., et al. 2018. J Agric Food Chem. 66: 5401-5409. PMID: 29745230

订购信息

产品名称产品编号规格价格数量收藏夹

CPEB 抗体 (G-6)

sc-514688
200 µg/ml
RMB2377.00

CPEB (G-6): m-IgG3 BP-HRP 套装

sc-550615
200 µg Ab; 40 µg BP
RMB2662.00

CPEB (G-6) 中和勝肽

sc-514688 P
100 µg/0.5 ml
RMB511.00

CPEB 抗体 (G-6) X

sc-514688 X
200 µg/0.1 ml
RMB2377.00

Is this antibody suitable for detecting CPEB1 in Western blot using Wistar rat samples?

Asked by: Abdullah
Thank you for your question. CPEB Antibody (G-6): sc-514688 is recommended for detection of CPEB (gene name CPEB1) long and short isoforms of mouse, rat and human origin by WB, IP, IF and ELISA.
Answered by: Tech Support Europe
Date published: 2024-12-06

Dear Santa Team, Hello, I want to ask your product CPEB Antikörper (G-6): sc-514688, how much of this molecular mass? From your example pictures, almost all have different molecular mass, so if I do WB, how much of the molecular mass it is predicted?

Asked by: Luyang
Thank you for your question. The expected molecular weight of CPEB in western blots is 63 kDa.
Answered by: Tech Support Europe
Date published: 2022-08-03

What application is the blocking peptide sc-514688 P appropriate for?

Asked by: AbPolly
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-28
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Rated 5 out of 5 by from Great specificity for CPEB in Western BlotThis antibody detects over-expressed human CPEB in sc-114376. Shown with Cruz Marker molecular weight standards, sc-2035. -SCBT QC
Date published: 2023-09-14
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CPEB 抗体 (G-6) is rated 5.0 out of 5 by 1.
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