Date published: 2025-9-9
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Cox-2 Antibody (29) - Immunohistochemistry - Image 348785
Cox-2抗体 (29): sc-19999. 福尔马林固定, 石蜡包埋的人精囊组织的免疫过氧化物酶染色, 显示腺细胞的胞浆染色.
Cox-2抗体 (29): sc-19999. 福尔马林固定, 石蜡包埋的人精囊组织的免疫过氧化物酶染色, 显示腺细胞的胞浆染色.

Cox-2 抗体 (29): sc-19999

4.4(22)
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说明书
  • Cox-2抗体(29)是小鼠单克隆IgG1 κ, 在240篇文献中引用，规格为200 µg/ml
  • 针对由human起源的Cox-2的氨基酸580-598组成的C-terminus肽
  • 抗-Cox-2 抗体 (29) 推荐用于 WB, IP, IF, IHC(P) 和 FCM，检测mouse, rat 和human 来源的 Cox-2
  • Cox-2 抗体 (29) 可偶联 藻红蛋白 或者 FITC 用于 IF, IHC(P) 和 FCM
  • 还可偶联Alexa Fluor® 594 用于IF, IHC(P) 和 FCM
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Cox-2 (29): sc-19999的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 Cox-2 抗体 (29) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Cox-2 抗体 (29) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 Cox 抗体 包括 Cox-2

Cox-2抗体（29）是一种小鼠单克隆IgG1 kappa轻链抗体，针对人类环氧化酶-2（Cox-2）的580-598个氨基酸组成的C端肽段 ），可与小鼠、大鼠和人类蛋白发生反应，适用于免疫印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、流式细胞术（FCM）和石蜡包埋切片免疫组化（IHCP）等应用。Cox-2，也称为前列腺素-内酯环氧化酶2（PTGS2），是一种诱导酶，在花生四烯酸转化为前列腺素的过程中起着关键作用，而前列腺素是一种参与炎症、疼痛和发烧的脂质介质。与常量表达的同工酶Cox-1不同，Cox-2在正常生理条件下表达量极低，但在炎症刺激、细胞因子、生长因子和肿瘤促进剂的作用下会显著上调。这种上调会导致前列腺素的生成增加，从而加剧炎症反应和疼痛感。Cox-2的过度表达与多种病理状况有关，包括慢性炎症、关节炎以及某些癌症的进展，如结肠癌、乳腺癌和肺癌。Cox-2是非甾体类抗炎药（NSAIDs）和选择性Cox-2抑制剂（coxibs）的关键治疗靶点，这些药物旨在通过抑制前列腺素的合成来减轻炎症和疼痛。了解Cox-2的表达和调节对于阐明炎症性疾病和癌症进展的机制至关重要，从而有助于制定有针对性的治疗策略。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cox-2 抗体 (29) 参考文献:

  1. 重组疫苗病毒过表达人前列腺素 G/H 合成酶-1 和-2：非甾体类消炎药的抑制作用和 15- 羟基二十碳四烯酸的生物合成。  |  O'Neill, GP., et al. 1994. Mol Pharmacol. 45: 245-54. PMID: 8114674
  2. 人体组织中环氧化酶-1 和环氧化酶-2 的 mRNA 表达。  |  O'Neill, GP. and Ford-Hutchinson, AW. 1993. FEBS Lett. 330: 156-60. PMID: 8365485
  3. 前列腺素合成酶 2 基因中断会导致小鼠肾脏严重病变。  |  Morham, SG., et al. 1995. Cell. 83: 473-82. PMID: 8521477
  4. 中断小鼠前列腺素合成酶 1 基因可减少花生四烯酸诱发的炎症和吲哚美辛诱发的胃溃疡。  |  Langenbach, R., et al. 1995. Cell. 83: 483-92. PMID: 8521478
  5. 过量表达前列腺素内过氧化物合成酶 2 的上皮细胞的细胞黏合剂和细胞凋亡的变化。  |  Tsujii, M. and DuBois, RN. 1995. Cell. 83: 493-501. PMID: 8521479
  6. 大脑皮层中的环氧化酶-2诱导：细胞内对突触兴奋的反应。  |  Adams, J., et al. 1996. J Neurochem. 66: 6-13. PMID: 8522990
  7. 白细胞介素-1β和肿瘤坏死因子α对关节软骨细胞产生 PGE2 的协同作用不涉及 PLA2 刺激。  |  Berenbaum, F., et al. 1996. Exp Cell Res. 222: 379-84. PMID: 8598226

订购信息

产品名称产品编号规格价格数量收藏夹

Cox-2 抗体 (29)

sc-19999
200 µg/ml
RMB2377.00

Cox-2 (29): m-IgG Fc BP-HRP 套装

sc-551228
200 µg Ab; 10 µg BP
RMB2662.00

Cox-2 (29): m-IgG1 BP-HRP 套装

sc-551227
200 µg Ab; 20 µg BP
RMB2662.00

Cox-2 抗体 (29) FITC

sc-19999 FITC
200 µg/ml
RMB2482.00

Cox-2 抗体 (29) PE

sc-19999 PE
200 µg/ml
RMB2580.00

Cox-2 抗体 (29) Alexa Fluor® 546

sc-19999 AF546
200 µg/ml
RMB2685.00

Cox-2 抗体 (29) Alexa Fluor® 594

sc-19999 AF594
200 µg/ml
RMB2685.00

Cox-2 抗体 (29) Alexa Fluor® 680

sc-19999 AF680
200 µg/ml
RMB2685.00

Cox-2 抗体 (29) Alexa Fluor® 790

sc-19999 AF790
200 µg/ml
RMB2685.00

I am interested in an anti-Cox-2 antibody that works in dog tissue. I would like to know if you have any

Asked by: Monica
Thank you for your question. We currently do not have any antibodies specific against Cox-2 that are recommended for use in canine cell or tissue samples.
Answered by: Tech Support Europe
Date published: 2023-12-06

What dilution of primary (COX 2) and secondary antibody do you recommend for Human Gingival Fibroblats?

Asked by: ChristianAndrea
Thank you for your question. Dilution is determined by what application the antibody is being used for . Here is a link to our protocols :https://www.scbt.com/resources/protocols
Answered by: BlakeJ
Date published: 2023-07-11

I have used Cayman COX-2 (mouse) Polyclonal Antibody (aa 584-598) antibody and I see two bands around the correct molecular weight. I need to validate these results with another antibody. Can I know the epitope of Cox-2 Antibody (29): sc-19999?

Asked by: Mahesha
Thank you for your question. This antibody was raised against amino acids 580-598 of Cox-2 of human origin, the exact epitope has not been epitope mapped.
Answered by: Tech Service
Date published: 2019-01-14

Which negative control should be used when using the FITC conjugated Cox-2 (29): sc-19999 : sc-21704 in flow cytometry?

Asked by: jenni
Thank you for your inquiry. We recommend using isotype specific normal mouse IgG3 conjugated to FITC, sc-2858
Answered by: Technical Support 6
Date published: 2020-05-10
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Rated 3 out of 5 by from ヒトTHP1細胞で使用可能ヒトTHP1細胞でLPS刺激による発現誘導をWBで確認できた。非特異的バンドがやや多いが実用的に使用できる。
Date published: 2024-07-11
Rated 5 out of 5 by from Western blotThe antibody can give a nice clean band. It is a good antibody.
Date published: 2024-07-01
Rated 2 out of 5 by from Scarso funzionamentoAbbiamo usato questo anticorpo su estratti totali di cellule SiHa e funziona male, con una banda dell'altezza attesa visibile solo dopo trattamento specifico
Date published: 2023-11-10
Rated 5 out of 5 by from Great antibody for WBThis primary antibody worked very well in Western blot.
Date published: 2021-03-31
Rated 5 out of 5 by from Excellent for WBTested both Cox2 antibody clones (29 and H3) against 3 mouse tumors that differed on the levels of Cox2, based on MS data. Blotting with both Cox2 antibody clones validated the MS result.
Date published: 2020-12-19
Rated 5 out of 5 by from Cox-2 antibody (Sc-19999)The Cox-2 antibody (Sc-19999) antibody was used for western blot analysis. The product origin is mouse. The product was good enough to get a clear band. I would strongly recommend this antibody for other users too.
Date published: 2020-08-20
Rated 1 out of 5 by from badCouldn´t detect the protein by western blot (dilution 1:100)
Date published: 2019-02-21
Rated 5 out of 5 by from Cox-2 Antibody works perfectlyWe have used this antibody to detect COX-2 in mouse microglia cells using Western blot.
Date published: 2018-10-18
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Cox-2 抗体 (29) is rated 4.4 out of 5 by 22.
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