Date published: 2025-9-8

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Cox-1 抗体 (11): sc-19998

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说明书
  • Cox-1 抗体 11 是小鼠单克隆 IgG2b κ,Cox-1抗体, 在60篇文献中引用,规格为200 µg/ml
  • 与Cox-1反应,从ovine精囊中纯化
  • Cox-1 抗体 (11) 推荐用于 WB, IP, IF, IHC(P) 和 FCM,检测mouse, rat, human 和ovine 来源的 Cyclooxygenase-1; 可能与 human recombinant, human platelet, rat and mouse COX-1 and slightly (5%) with ovine COX-2产生交联反应; 不会与 human or mouse COX-2产生交联反应
  • 抗Cox-1抗体(11)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Cox-1 (11): sc-19998免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG2b BP-HRPm-IgGκ BP-HRP 是 Cox-1 抗体 (11) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Cox-1 抗体 (11) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

Cox-1抗体(11)是一种小鼠单克隆IgG2b kappa轻链抗体,用于检测多种物种(包括小鼠、大鼠、人类和绵羊)的环氧化酶-1(COX-1),也称为PTGS1或前列腺素-内过氧化物酶合酶1。COX-1小鼠单克隆抗体(11)针对从绵羊精囊中纯化的COX-1制备,可确保与靶标表位牢固而特异性结合。COX-1是一种参与前列腺素生物合成的重要酶,前列腺素是调节炎症、血流和血栓形成等多种生理过程的重要脂质化合物。通过催化花生四烯酸转化为前列腺素H2(PGH2),COX-1在维持正常细胞功能方面发挥着至关重要的作用。COX-1单克隆抗体(11)用途广泛,在蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、石蜡包埋切片免疫组织化学(IHCP)和流式细胞术(FCM)中表现可靠。此外,COX-1 单克隆抗体(11)有多种结合形式,包括辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种 Alexa Fluor® 变体,以满足不同的实验需求。COX-1 单克隆抗体(11)使研究人员能够研究 COX-1 的表达、定位和功能动态,揭示其在生理和病理过程中的作用,并促进对脂质信号传导和炎症的新见解。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cox-1 抗体 (11) 参考文献:

  1. 重组疫苗病毒过表达人前列腺素 G/H 合成酶-1 和-2:非甾体类消炎药的抑制作用和 15- 羟基二十碳四烯酸的生物合成。  |  O'Neill, GP., et al. 1994. Mol Pharmacol. 45: 245-54. PMID: 8114674
  2. 人体组织中环氧化酶-1 和环氧化酶-2 的 mRNA 表达。  |  O'Neill, GP. and Ford-Hutchinson, AW. 1993. FEBS Lett. 330: 156-60. PMID: 8365485
  3. 前列腺素合成酶 2 基因中断会导致小鼠肾脏严重病变。  |  Morham, SG., et al. 1995. Cell. 83: 473-82. PMID: 8521477
  4. 中断小鼠前列腺素合成酶 1 基因可减少花生四烯酸诱发的炎症和吲哚美辛诱发的胃溃疡。  |  Langenbach, R., et al. 1995. Cell. 83: 483-92. PMID: 8521478
  5. 过量表达前列腺素内过氧化物合成酶 2 的上皮细胞的细胞黏合剂和细胞凋亡的变化。  |  Tsujii, M. and DuBois, RN. 1995. Cell. 83: 493-501. PMID: 8521479
  6. 大脑皮层中的环氧化酶-2诱导:细胞内对突触兴奋的反应。  |  Adams, J., et al. 1996. J Neurochem. 66: 6-13. PMID: 8522990
  7. 白细胞介素-1β和肿瘤坏死因子α对关节软骨细胞产生 PGE2 的协同作用不涉及 PLA2 刺激。  |  Berenbaum, F., et al. 1996. Exp Cell Res. 222: 379-84. PMID: 8598226

订购信息

产品名称产品编号规格价格数量收藏夹

Cox-1 抗体 (11)

sc-19998
200 µg/ml
RMB2377.00

Cox-1 (11): m-IgG Fc BP-HRP 套装

sc-528346
200 µg Ab; 10 µg BP
RMB2662.00

Cox-1 (11): m-IgGκ BP-HRP 套装

sc-520700
200 µg Ab, 40 µg BP
RMB2662.00

Cox-1 (11): m-IgG2b BP-HRP 套装

sc-550031
200 µg Ab; 10 µg BP
RMB2662.00

Cox-1 抗体 (11) AC

sc-19998 AC
500 µg/ml, 25% agarose
RMB3129.00

Cox-1 抗体 (11) HRP

sc-19998 HRP
200 µg/ml
RMB2377.00

Cox-1 抗体 (11) FITC

sc-19998 FITC
200 µg/ml
RMB2482.00

Cox-1 抗体 (11) PE

sc-19998 PE
200 µg/ml
RMB2580.00

Cox-1 抗体 (11) Alexa Fluor® 488

sc-19998 AF488
200 µg/ml
RMB2685.00

Cox-1 抗体 (11) Alexa Fluor® 546

sc-19998 AF546
200 µg/ml
RMB2685.00

Cox-1 抗体 (11) Alexa Fluor® 594

sc-19998 AF594
200 µg/ml
RMB2685.00

Cox-1 抗体 (11) Alexa Fluor® 647

sc-19998 AF647
200 µg/ml
RMB2685.00

Cox-1 抗体 (11) Alexa Fluor® 680

sc-19998 AF680
200 µg/ml
RMB2685.00

Cox-1 抗体 (11) Alexa Fluor® 790

sc-19998 AF790
200 µg/ml
RMB2685.00

What is the best way to use sc-19998 for IHC in my mouse tissues?

Asked by: Cweed
We recommend using directly conjugated primary antibodies. This product, sc-19998, is available directly conjugated to FITC, AF488, and AF647.
Answered by: Technical Support 15
Date published: 2017-01-25
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Rated 5 out of 5 by from 功能出色一个月前购买过此商品,用做IHC,对象是人类结肠标本。总体很满意,效果很好,购物体验很好希望再次购买
Date published: 2023-01-12
Rated 5 out of 5 by from Good for Western blotI bought it for Western blot analysis, and it works well in ovine liver.
Date published: 2021-04-16
Rated 4 out of 5 by from Good resultI bought old version of it. Really worked. Want to order new now.
Date published: 2021-04-08
Rated 1 out of 5 by from Not recommended for IFI got a sample to test on both Cos7 and HeLA cells. The staining is very unspecific as compared to other mitochondrial markers and the papers Santa Cruz references have very low resolution images that can't be used as a reference point. Would not recommend for immunofluorescence.
Date published: 2018-08-13
Rated 2 out of 5 by from Works okay for WB analysisTried 1:1000 dilution. Signal detected for human bladder cancer cells but not canine.
Date published: 2018-06-19
Rated 5 out of 5 by from Anticuerpo que funciona.Hemos probado este anticuerpo en celulas estrelladas pancreaticas, y hemos podido detectar la proteina con este anticuerpo. Podemos decir que funciona bien.
Date published: 2018-02-14
Rated 5 out of 5 by from Great antibody!We bought this antibody for cox-1 detection in human platelets . We obtained specific and clear bands with a 1:2000 dilution.
Date published: 2017-08-02
Rated 5 out of 5 by from Cell stainingIt's a good choice to use it, The staining is cytosolic in human fallopian tube tissue as expected.
Date published: 2017-05-09
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Cox-1 抗体 (11) is rated 4.4 out of 5 by 18.
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