Date published: 2025-9-11

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Cosmc 抗体 (H-10): sc-271829

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说明书
  • Cosmc 抗体 H-10 是小鼠单克隆 IgG1 κ,Cosmc抗体, 在8篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列1-270位于human物种的Cosmc的N-terminus
  • Cosmc 抗体 (H-10) 推荐用于WB, IP, IF 和 ELISA,检测human 来源的 Cosmc
  • 抗Cosmc抗体(H-10)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 另提供生物素偶联抗体,可用于WB、IHC(P)和ELISA实验
  • 关于如何获取Cosmc (H-10): sc-271829免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是Cosmc Antibody (H-10) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Cosmc Antibody (H-10) 打包提供(请参阅下面的订购信息)。

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関連項目

Cosmc抗体(H-10)是一种IgG1 κ小鼠单克隆Cosmc抗体,能够通过WB、IP、IF和ELISA检测到人源Cosmc蛋白。Cosmc抗体(H-10)既有非偶联型抗Cosmc抗体形式,也有多种偶联型抗Cosmc抗体形式,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Cosmc,或C1GALT1特异性伴侣蛋白1,是一种由人类基因C1GALT1C1编码的含318个氨基酸的蛋白质。Cosmc被认为是生成1型O-聚糖Gal-b1-3GalNAc-a1-Ser/Thr(Tn抗原)所需的伴侣蛋白,这是糖蛋白中许多扩展的O-聚糖的前体。Cosmc也可能作为特定的分子伴侣蛋白,协助核心1 b-3-半乳糖基转移酶(C1GALT1)的折叠/稳定性。Cosmc是一种单次跨膜II型膜蛋白。Cosmc在所有组织类型中都有表达。它在小肠、胃、唾液腺、肾脏和睾丸中的表达量最高,在全脑、小脑、脊髓、胸腺、脾脏、气管、肺、胰腺、卵巢和子宫中的表达量适中。C1GALT1C1的缺陷是引起Tn综合征的原因,这是一种罕见的自身免疫性疾病,由C1GALT1C1基因的体细胞突变引起,其中所有谱系血细胞的亚群携带一种不完全糖基化的Tn抗原,影响红细胞和血小板,导致贫血、白细胞减少和血小板减少。Tn多聚凝集性有时与白血病相关,或处于白血病前期状态。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cosmc 抗体 (H-10) 参考文献:

  1. 克隆CD34+造血干细胞/祖细胞中表达的300个以前未定义的基因的cDNA,并对其开放阅读框进行功能分析。  |  Zhang, QH., et al. 2000. Genome Res. 10: 1546-60. PMID: 11042152
  2. 新型 UDP-Gal:GalNAc(α)肽 beta 1,3-半乳糖基转移酶(C1Gal-T2)的分子克隆和表征,这是一种合成 O-聚糖核心 1 结构的酶。  |  Kudo, T., et al. 2002. J Biol Chem. 277: 47724-31. PMID: 12361956
  3. 哺乳动物核心 1 beta 3-半乳糖基转移酶活性所需的独特分子伴侣 Cosmc。  |  Ju, T. and Cummings, RD. 2002. Proc Natl Acad Sci U S A. 99: 16613-8. PMID: 12464682
  4. 免疫球蛋白 A 肾病中外周 B 淋巴细胞 beta1,3-半乳糖基转移酶和伴侣蛋白的表达。  |  Qin, W., et al. 2005. J Intern Med. 258: 467-77. PMID: 16238683
  5. 蛋白质糖基化:Tn综合征中的伴侣突变。  |  Ju, T. and Cummings, RD. 2005. Nature. 437: 1252. PMID: 16251947
  6. 鉴定秀丽隐杆线虫的核心 1 O-聚糖 T 合成酶  |  Ju, T., et al. 2006. Glycobiology. 16: 947-58. PMID: 16762980
  7. 突变伴侣将野生型蛋白质转化为肿瘤特异性抗原。  |  Schietinger, A., et al. 2006. Science. 314: 304-8. PMID: 17038624

订购信息

产品名称产品编号规格价格数量收藏夹

Cosmc 抗体 (H-10)

sc-271829
200 µg/ml
RMB2377.00

Cosmc (H-10): m-IgG Fc BP-HRP 套装

sc-529268
200 µg Ab; 10 µg BP
RMB2662.00

Cosmc (H-10): m-IgGκ BP-HRP 套装

sc-522072
200 µg Ab, 40 µg BP
RMB2662.00

Cosmc (H-10): m-IgG1 BP-HRP 套装

sc-543423
200 µg Ab; 20 µg BP
RMB2662.00

Cosmc 抗体 (H-10) AC

sc-271829 AC
500 µg/ml, 25% agarose
RMB3129.00

Cosmc 抗体 (H-10) HRP

sc-271829 HRP
200 µg/ml
RMB2377.00

Cosmc 抗体 (H-10) FITC

sc-271829 FITC
200 µg/ml
RMB2482.00

Cosmc 抗体 (H-10) PE

sc-271829 PE
200 µg/ml
RMB2580.00

Cosmc 抗体 (H-10) Alexa Fluor® 488

sc-271829 AF488
200 µg/ml
RMB2685.00

Cosmc 抗体 (H-10) Alexa Fluor® 546

sc-271829 AF546
200 µg/ml
RMB2685.00

Cosmc 抗体 (H-10) Alexa Fluor® 594

sc-271829 AF594
200 µg/ml
RMB2685.00

Cosmc 抗体 (H-10) Alexa Fluor® 647

sc-271829 AF647
200 µg/ml
RMB2685.00

Cosmc 抗体 (H-10) Alexa Fluor® 680

sc-271829 AF680
200 µg/ml
RMB2685.00

Cosmc 抗体 (H-10) Alexa Fluor® 790

sc-271829 AF790
200 µg/ml
RMB2685.00

Cosmc 抗体 (H-10) B

sc-271829 B
200 µg/ml
RMB2407.00

Dear representative, I have been using CosmcH10 antibody for almost a decade and I am planning to use more. I am looking for Cosmc (H-10), sc-271829, lot #F3021 or G2023. Do you have more antibodies from these lots? looking forward to hearing from you!

Asked by: Raj Aryal
Thank you for contacting Santa Cruz Biotechnology. To request information on a lot please email [email protected].
Answered by: BlakeJ
Date published: 2024-12-12

What is the recommended starting dilution for Western blot for sc-271829: Cosmc (H-10) monoclonal antibody?

Asked by: Professor Griffin
The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, is available in the recommended protocol: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
Answered by: Technical Support
Date published: 2017-03-22
  • y_2025, m_9, d_10, h_9CST
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Rated 5 out of 5 by from good consequenceI use the antibody to detect the re-portein from overexpress CHO cell and it works well.
Date published: 2017-07-05
Rated 5 out of 5 by from Produced nice Western blot data of CosmcProduced nice Western blot data of Cosmc expression in MIA PaCa-2, HEK293, Hep G2 and HeLa whole cell lysates. -SCBT QC
Date published: 2014-01-30
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Cosmc 抗体 (H-10) is rated 5.0 out of 5 by 2.
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