Date published: 2025-9-7
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Coronin 1A Antibody (14.1) - Western Blotting - Image 368206
Coronin 1A 抗体 (14. 1): sc-100925. Jurkat (A), HL-60 (B) 和 RAW 264. 7 (C) 全细胞裂解液以及小鼠脾脏 (D) 和大鼠脾脏 (E) 组织提取物中 Coronin 1A 表达的 Western 印迹分析.
Coronin 1A 抗体 (14. 1): sc-100925. Jurkat (A), HL-60 (B) 和 RAW 264. 7 (C) 全细胞裂解液以及小鼠脾脏 (D) 和大鼠脾脏 (E) 组织提取物中 Coronin 1A 表达的 Western 印迹分析.

Coronin 1A 抗体 (14.1): sc-100925

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说明书
  • Coronin 1A 抗体 14.1 是小鼠单克隆 IgG2a κ，Coronin 1A抗体, 在12篇文献中引用，规格为100 µg/ml
  • 与human起源的Coronin 1A的C-terminal区域
  • 推荐用于 mouse, rat 和 human 来源的Coronin 1A WB, IP, IF, IHC(P) 和 ELISA检测
  • 关于如何获取Coronin 1A (14.1): sc-100925的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG2a BP-HRP 是 Coronin 1A 抗体 (14.1) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Coronin 1A 抗体 (14.1) 组合成套装提供。 (请参阅下面的订购信息)。

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研究信息

関連項目

此外 Coronin 抗体 包括 Coronin 1A, Coronin 1B, Coronin 1C和Coronin 2A

Coronin 1A抗体（14.1）是一种IgG2a κ小鼠单克隆Coronin 1A抗体（也被指定为CORO1A抗体、TACO抗体），可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、免疫组织化学（IHC(P)）和酶联免疫吸附测定（ELISA）检测小鼠、大鼠和人源的Coronin 1A蛋白。Coronin 1A抗体（14.1）为非偶联抗Coronin 1A抗体形式。Coronin蛋白是一类含有WD重复序列的肌动蛋白结合蛋白，它们定位于亚膜区域，调节细胞运动和细胞骨架重排。Coronin 1A（CORO1A、CLIPINA、CLABP、TACO、p57）可以形成卷曲螺旋介导的同三聚体复合物，影响早期吞噬体的形成。蛋白激酶C（PKC）依赖性地在丝氨酸2处对Coronin 1B（CORO1B）进行磷酸化，通过与Arp2/3复合物的相互作用调节成纤维细胞的前沿动力学和细胞运动。Coronin 1C（CORO1C、Coronin 3、HCRNN4）在分化的Neuro-2a细胞、PC-12细胞和原代少突胶质细胞中丰富，据认为可以影响神经元的形态发生和迁移。Coronin 2A（CORO2A、CLIPINB、IR10、WDR2）是由10-12个蛋白质组成的约1.5-2兆道尔顿的N-CoR（核受体共抑制因子）复合物的组成部分，该复合物招募HDACs以产生抑制性染色质。Coronin 7（CORO7、CRN7）定位于高尔基体膜，影响细胞内膜隔室的组织和囊泡运输。Coronin 2B（CORO2B、CLIPINC）和Coronin 6（CORO6）与该家族的其他成员相似，因为它们拥有一个保守的碱性N端基序和聚集在一个至两个核心结构域中的3-10个WD重复序列。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Coronin 1A 抗体 (14.1) 参考文献:

  1. Coronin 定域于前缘，参与脊椎动物细胞的细胞扩散和薄层基质扩展。  |  Mishima, M. and Nishida, E. 1999. J Cell Sci. 112 (Pt 17): 2833-42. PMID: 10444378
  2. 无处不在的哺乳动物冠状病毒 3 的聚合, F-肌动蛋白相互作用和膜缔合作用是由其羧基末端介导的。  |  Spoerl, Z., et al. 2002. J Biol Chem. 277: 48858-67. PMID: 12377779
  3. 人类 N-CoR 复合物的纯化和功能特征：HDAC3, TBL1 和 TBLR1 的作用。  |  Yoon, HG., et al. 2003. EMBO J. 22: 1336-46. PMID: 12628926
  4. 哺乳动物 POD-1 的同源物 Coronin 7 定位于高尔基体。  |  Rybakin, V., et al. 2004. FEBS Lett. 573: 161-7. PMID: 15327992
  5. 白细胞质膜通过盘绕线圈介导的三聚冠状蛋白 1 分子与肌动蛋白细胞骨架缔合作用。  |  Gatfield, J., et al. 2005. Mol Biol Cell. 16: 2786-98. PMID: 15800061
  6. 冠状病毒素 3 及其在小鼠大脑形态发生中的作用  |  Hasse, A., et al. 2005. Eur J Neurosci. 21: 1155-68. PMID: 15813925
  7. 吞噬体的形成需要 Coronin-1 的功能。  |  Yan, M., et al. 2005. Mol Biol Cell. 16: 3077-87. PMID: 15829569
  8. Coronin 蛋白是细胞骨架和膜贩运的多功能调节器。  |  Rybakin, V. and Clemen, CS. 2005. Bioessays. 27: 625-32. PMID: 15892111
  9. 蛋白激酶 C 对冠状病毒素 1B 的磷酸化调节其与 Arp2/3 的相互作用和细胞运动。  |  Cai, L., et al. 2005. J Biol Chem. 280: 31913-23. PMID: 16027158
  10. Coronin-1A：人类和小鼠的免疫缺陷。  |  Punwani, D., et al. 2015. J Clin Immunol. 35: 100-7. PMID: 25666293
  11. 冠状蛋白-1a在神经元信号传导中的新兴作用。  |  Martorella, M., et al. 2017. Vitam Horm. 104: 113-131. PMID: 28215292
  12. 冠状病毒蛋白 1A 在 HIV-1 神经发病机制中促进钙动员并提高星形胶质细胞的反应性。  |  Pandey, HS., et al. 2022. FASEB Bioadv. 4: 254-272. PMID: 35415462

订购信息

产品名称产品编号规格价格数量收藏夹

Coronin 1A 抗体 (14.1)

sc-100925
100 µg/ml
RMB2504.00

Coronin 1A (14.1): m-IgG Fc BP-HRP 套装

sc-539723
100 µg Ab; 10 µg BP
RMB2662.00

Coronin 1A (14.1): m-IgG2a BP-HRP 套装

sc-546771
100 µg Ab; 10 µg BP
RMB2662.00

Is Coronin 1A (14.1) monoclonal antibody suitable for IHC/IF?

Asked by: Ariamino
Thank you for your question. Yes, this mouse monoclonal antibody, Coronin 1A (14.1): sc-100925, is recommended for IHC(P) and IF. Immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, as well as immunofluorescence on fresh or frozen tissues or cells.
Answered by: Technical Support
Date published: 2017-10-25

I was using coronin1A antibody (sc-366201). I was planning to order it again but the problem is that the current list of coronin 1a antibodies is not having this one on this website. What should I do?

Asked by: Hriday S Pandey
Thank you for your question. Our rabbit polyclonal antibody, sc-366201: Coronin 1A (H-300) is now discontinued. As an alternative, we would recommend using our new mouse monoclonal antibody, Coronin 1A (14.1): sc-100925. https://www.scbt.com/scbt/product/coronin-1a-antibody-14-1
Answered by: Technical Support
Date published: 2017-09-28

I was using coronin1A antibody (sc-366201). I was planning to order it again but the problem is that the current list of coronin 1a antibodies on the website is not having this one. What should I do?

Asked by: Hriday
Thank you for your question. That rabbit polyclonal antibody, sc-366201, is now discontinued. We do offer a suggested replacement mouse monoclonal antibody, Coronin 1A (14.1): sc-100925. https://www.scbt.com/scbt/product/coronin-1a-antibody-14-1
Answered by: Technical Support
Date published: 2017-09-27

Can sc-100925: Coronin 1A (14.1) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: TinTin
Thank you for your question. Yes, sc-100925: Coronin 1A (14.1) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from Ottimo funzionamento su linfonodo caninoTestato con smascheramento ph 6.0 e concentrazione 1:100.
Date published: 2022-12-21
Rated 5 out of 5 by from greatIt works great, the response is perfect, I get the results I want
Date published: 2022-02-03
Rated 2 out of 5 by from Very weak signalUsed a 1:300 dilution for WB with 1- SUM159, 2- Caco-2, and 3- 293-T cell lysates. Detected a single band but the signal was very weak.
Date published: 2018-01-30
Rated 5 out of 5 by from WB for mouse brain was worked well.WB for mouse brain was worked well. Signal intensity was strong.
Date published: 2017-12-09
Rated 5 out of 5 by from Great IHC and WB antibodyObserved specific stain and desired band with Coronin 1A Antibody (14.1)
Date published: 2017-01-23
Rated 4 out of 5 by from WB publishable data with NCIWB publishable data with NCI-H441 cell line and female BALB/c mice - SCBT Publication Review
Date published: 2015-04-29
Rated 4 out of 5 by from Good specificity in WB in KGood specificity in WB in K-562 whole cell lysate. -SCBT QC
Date published: 2015-04-13
Rated 4 out of 5 by from Robust signal in WB in human transfectedRobust signal in WB in human transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-01-15
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Coronin 1A 抗体 (14.1) is rated 4.2 out of 5 by 9.
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