Cordycepin CAS: 73-03-0
MF: C10H13N5O3
MW: 251.24
An anticancer, antifungal nucleoside analog.

Cordycepin (CAS 73-03-0)

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Alternate Names: 3'-Deoxyadenosine
Application: Cordycepin is an anticancer, antifungal nucleoside analog
CAS Number: 73-03-0
Purity: ≥98%
Molecular Weight: 251.24
Molecular Formula: C10H13N5O3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Cordycepin is a nucleoside analog that acts as an anticancer and antifungal agent. Cordycepin inhibits growth of various tumor cells in vitro. It can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Cordycepin is also useful for the study of messenger RNA transcription.


参考文献

1. Gumport, R.I., et al. 1976. Biochemistry. 15: 2804-2809. PMID: 779831
2. Sugar, A.M., et al. 1998. Antimicrob. Agents Chemother. 42: 1424-1427. PMID: 9624488
3. Kodama, E.N., et al. 2000. Biochem. Pharmacol. 59: 273-281. PMID: 10609556

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), methanol, and water.
Storage :
Desiccate at 4° C
Melting Point :
225° C
Boiling Point :
~627.2° C at 760 mmHg (Predicted)
Density :
1.92 g/cm3 (Predicted)
Refractive Index :
n20D 1.86 (Predicted)
IC50 :
Vero: IC50 = 0.5 nM (Chlorocebus aethiops); Mitochondrial import inner membrane translocase subunit TIM23: IC50 = 14 µM (Saccharomyces cerevisiae S288c); Plasmodium falciparum: IC50 = 17.9 µM (Plasmodium falciparum K1); Hepatitis C virus NS5B RNA-dependent RNA polymerase: IC50 = 22 µM (Hepatitis C virus)
Ki Data :
Adenosine A1 receptor: Ki= 7.12 µM (rat)
pK Values :
pKa: 13.64 (Predicted), pKb: 3.82 (Predicted)
仅供科研使用。不可用于诊断或治疗。
WGK Germany :
3
RTECS :
AU7358610
PubChem CID :
6303
Merck Index :
14: 2529
MDL Number :
MFCD00037998
EC Number :
200-791-4
Beilstein Registry :
35194
SMILES :
C1[[email protected]](O[[email protected]]([[email protected]@H]1O)N2C=NC3=C2N=CN=C3N)CO

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Citations 1 to 3 of 3 total

PMID: # 22910906  2012. J. Biol. Chem. 287: 34361-71.

PMID: # 31951250  Acta Biochim. Biophys. Sin. (Shanghai).

PMID: # 31746344  Int. J. Mol. Med. 45: 141-150.

Citations 1 to 3 of 3 total
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