Date published: 2025-9-7

021-6093-6350

SCBT Portrait Logo
Seach Input

connexin 26 抗体 (1C6): sc-293223

5.0(1)
寫評論提問

说明书
  • connexin 26 抗体 1C6 是小鼠单克隆 IgG2b κ,connexin 26抗体, 在1篇文献中引用,规格为100 µg/ml
  • 免疫human物种的代表全长connexin 26的氨基酸1-226
  • 推荐用于 human 来源的connexin 26 WB, IP 和 ELISA检测
  • 目前,我们还没有完成connexin 26 抗体 (1C6)的首选二抗检测试剂的鉴定。这项工作正在进行中。

快捷链接

関連項目

连接蛋白26抗体(1C6)是一种小鼠单克隆IgG2b kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)和酶联免疫吸附测定(ELISA)检测人类样本中的连接蛋白26蛋白(也称为GJB2)。抗连接蛋白26抗体(1C6)以非结合形式提供,专门用于促进人体组织中间隙连接的研究。连接蛋白26(1C6)单克隆抗体在研究间隙连接中起着至关重要的作用,间隙连接对于细胞间通信至关重要,允许相邻细胞之间传输离子和小分子。这种功能对于维持各种组织(包括内耳耳蜗)的稳态尤为重要,其中,连接蛋白26对于听觉功能至关重要。编码连接蛋白26的GJB2基因突变与大约一半的常染色体隐性非综合征性听力损失病例有关,这凸显了连接蛋白26在感官生物学中的重要性。连接蛋白能够形成具有不同渗透性的独特通道,这凸显了细胞通讯的复杂性及其对健康和疾病的影响。抗连接蛋白26抗体(1C6)使研究人员能够深入了解听力损失和其他与间隙连接功能受损相关的疾病的分子机制。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

connexin 26 抗体 (1C6) 参考文献:

  1. 附件信道的新问题:生物物理学填补了空白。  |  Harris, AL. 2001. Q Rev Biophys. 34: 325-472. PMID: 11838236
  2. 听力损失基因筛查。  |  Hone, SW. and Smith, RJ. 2003. Clin Otolaryngol Allied Sci. 28: 285-90. PMID: 12871240
  3. 常染色体隐性遗传性耳聋疾病中的连接蛋白 26 突变:综述。  |  Apps, SA., et al. 2007. Int J Audiol. 46: 75-81. PMID: 17365058
  4. 耳聋和皮肤病中的Connexin-26突变。  |  Lee, JR. and White, TW. 2009. Expert Rev Mol Med. 11: e35. PMID: 19939300
  5. Hirschsprung's 疾病患者的连接蛋白 26 和连接蛋白 43 表达减少。  |  Coyle, D., et al. 2016. J Surg Res. 206: 242-251. PMID: 27916369
  6. 与非综合征听力损失(NSHL)相关的连接蛋白 26 (GJB2) 突变。  |  Mishra, S., et al. 2018. Indian J Pediatr. 85: 1061-1066. PMID: 29542069
  7. 哺乳动物心肌细胞中连接蛋白 26 的表达  |  Moscato, S., et al. 2018. Sci Rep. 8: 13975. PMID: 30228305
  8. 连接蛋白 26 错义突变导致掌跖角化症综合征听力损失。  |  Lam, MW., et al. 2020. Int J Dermatol. 59: e454-e455. PMID: 32808299
  9. 人类心脏间隙连接:分离, 超微结构和蛋白质组成。  |  Manjunath, CK., et al. 1987. J Mol Cell Cardiol. 19: 131-4. PMID: 3573042
  10. 连接蛋白 26、30 和 43 的细胞膜贩运途径  |  Zong, YJ., et al. 2023. Int J Mol Sci. 24: PMID: 37373495
  11. 化学伴侣恢复连接蛋白 26 突变体的活性  |  Wang, D., et al. 2023. ACS Pharmacol Transl Sci. 6: 997-1005. PMID: 37470015
  12. 人类膀胱癌细胞中的连接蛋白表达和细胞间通信减少。  |  Grossman, HB., et al. 1994. Cancer Res. 54: 3062-5. PMID: 8187096

订购信息

产品名称产品编号规格价格数量收藏夹

connexin 26 抗体 (1C6)

sc-293223
100 µg/ml
RMB2377.00

For Western Blot, is it recommended to use denatured or non-denatured conditions with connexin 26 (1C6): sc-293223 antibody?

Asked by: Professor Griffin
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27

Hi, is this (sc-293223 ) antibody working with GJB2 endogenous levels? Thanks

Asked by: michela
Thank you for your question. This brand new mouse monoclonal, connexin 26 Antibody (1C6): sc-293223, is recommended for detection of endogenous levels of connexin 26 of human origin. However, we do not have published data demonstrating this reactivity at this time. The antibody is warrantied for use in WB, IP and ELISA. If the antibody does not perform in any of the recommended applications, please contact our Technical Service Department and we can replace or refund your purchase.
Answered by: Technical Support
Date published: 2017-03-03
  • y_2025, m_9, d_7, h_4CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_zh_CN, sid_293223, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 103ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Good for Western BlotAntibody has been used to detect connexin 26 by Western Blot in published research. -SCBT QC
Date published: 2023-09-14
  • y_2025, m_9, d_7, h_4
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_zh_CN, sid_293223, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 19ms
  • REVIEWS, PRODUCT
connexin 26 抗体 (1C6) is rated 5.0 out of 5 by 1.
  • y_2025, m_9, d_7, h_4
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_zh_CN, sid_293223, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 108ms
  • REVIEWS, PRODUCT